Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0085437 (bacterial meningitis)
 4,038 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A relapse of acute myeloid leukaemia occurred in a 45-year-old woman 18 months after the disease was initially diagnosed and treated. During remission reinduction therapy, she developed a Gram-negative septicaemia, acute respiratory failure, acute renal failure, diabetic hyperglycaemia with ketoacidosis, and probable bacterial meningitis. She required assisted respiration for two days, received peritoneal dialysis for five days, and was unconscious for seven days. The patient eventually recovered, achieved full remission of her leukaemia, and survived a further 2 1/2 years, mostly in excellent health. Oncologists are often criticized for unjustifiable optimism and excessive zeal in the treatment of patients with malignant disease. This case illustrates that such optimism and zeal may be justified, and that intensive efforts to save the lives of seriously ill patients with chemosensitive malignant diseases are worthwhile.
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PMID:How zealously should a patient with relapsed acute myeloid leukaemia be treated? Good survival after five simultaneous, potentially lethal, complications. 658 66

A 59-years old man, having untreated hypertension and diabetes, was admitted to our hospital because of lumbago and fever. A T2-weighted image of spine showed increased signal intensity of vertebra at L3 and L4. Methicillin-susceptible staphylococcus aureus (MSSA) infection was confirmed by blood culturing. Cerebrospinal fluid (CSF) analysis showed pleocytosis. Diagsosis of pyogenic spondylitis with bacterial meningitis was made. Diffusion-weighted magnetic imaging of the brain disclosed a focal hyperintense lesion in the corpus callosum which showed a low coefficient in the apparent diffusion coefficient mapping. This finding suggests a clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS). His symptoms temporarily ameliorated by antibiotic therapy. Two weeks later, however, his conscious level rapidly worsened to comatose state. Concomitantly he developed acute renal failure with severe proteinuria. Serum serology showed a positive cryoglobulin test. Mechanical ventilation, hemodialysis and steroid pulse therapy improved his consciousness with a resultant complete recovery of all symptoms. We emphasize the possible complications in some cases of MERS.
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PMID:A case of Staphylococcus aureus meningitis associated with cryoglobulin-related renal failure and clinically mild encephalitis/encephalopathy with a reversible splenial lesion. 2715 Dec 24