Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0085437 (bacterial meningitis)
 4,038 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

It is the policy at the Jordan University Hospital to perform lumbar puncture on children with gastroenteritis who present with one or more of the following: age less than 1 month, convulsions, hypoactivity or marked irritability, and depressed sensorium. Review of the records of 737 children admitted with gastro-enteritis between January 1980 and October 1984 showed that lumbar puncture was performed on 351 (47.6%) children. Acute bacterial meningitis was diagnosed in only three children, two of whom had already received treatment before admission and the third had obvious meningeal signs. These findings do not justify the present policy on lumbar puncture in children with gastroenteritis and it is proposed that the procedure be reserved for children in whom abnormal CNS findings persist after initial correction of fluid and electrolyte balance or with overt signs of meningitis.
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PMID:Association of meningitis with infantile gastro-enteritis. 243 31

Inpatient and community-based care can be complementary in relation to the management of HIV disease. Medical records from 200 inpatients of Chikankata Hospital near Lusaka, Zambia and 200 home based patients were examined and compared for the common symptoms of presentation of HIV disease, associated opportunistic infections, and treatment protocols. Drug costs of both groups were also compared. The most common respiratory symptoms in the 2 groups are cough, chest pains, weight loss, and hemoptysis. Treatment employed for these symptoms were cortimoxazole, penicillin V, erthromycin, and tetracycline. Acetyl saliclic acid and paracetamol were used for pain relief in both groups. Gastointestinal system symptoms for both groups were diarrhea, weight loss, abdominal pain, and vomiting. Cotrimoxazole and metronidazole were used in treating diarrhea. Additional treatment protocol for the 2 patient samples included oral rehydration therapy for dehydration, antacid or bismuth subsalicylate for diarrhea and enteritis, and mycostatin for oral candidiasis. Central nervous system symptomatology included headache, dementia, neckace, and lethargy. Chloramphenicol was employed in treating bacterial meningitis. Diazepam and chlorpromazine were effective for restless patients. Genito-urinary system symptomatology for the 2 groups included dysuria, genital ulcers, hematuria, viral warts, and buboes. Antibodies were used for sexually transmitted diseases and infections. Skin symptomatology included rash and dermatitis, herpes zoster, abscess, kaposi's sarcoma, ulcers, furunculosis, and discharging anal sinus. In treating these symptoms, hospital based care and home based care were similar. Overall, it was found that hospital treatment protocols were detailed, expensive, and time consuming. Furthermore, hospital treatment for HIV positive patients is more expensive than HIV negative patients; hospital costs for 50 HIV negative patients totaled US$415.94 compared to US$1204.98 HIV positive/PTB negative patients and US$1705.62 for HIV positive/PTB positive patients. Drug cost/patient admission is increased by 469% if HIV positive. (author's modified).
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PMID:Clinical care as part of integrated AIDS management in a Zambian rural community. 248 94

A study was done on 111 children admitted in a university hospital in Tehran with fever and seizures to document the pattern of illness and to define indications for performing a lumbar puncture in children with fever and convulsions. Bacterial meningitis was diagnosed in 4 patients, aseptic meningitis in 2 and 105 children had febrile seizures. The cause of fever was gastro-enteritis in 39 patients and upper respiratory tract infection with or without Otitis media in 40. Although most patients were drowsy on admission (n = 93), none had any signs of meningeal irritation, except one child with slight nuchal rigidity. Out of the 4 children with bacterial meningitis, 3 had meningeal signs, but in one 10 month old baby with no signs, the diagnosis was made on the cerebro-spinal fluid findings after a lumbar puncture. These results support the view that a lumbar puncture should be performed on all infants under 12 months who present with fever and convulsions and strongly considered between 12 and 18 months. After 18 months a lumbar puncture is mandatory in the presence of signs of meningeal irritation.
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PMID:Febrile seizures: clinical course and diagnostic evaluation. 1002 96

S100B has been shown to increase in cerebrospinal fluid (CSF) and serum after various neurological diseases and it has been postulated that S100B could serve as a serum marker for brain damage. However there is limited information concerning serum S100B levels in infectious diseases of the brain. Blood samples were collected from patients at the Department of Infectious Diseases at or soon after admission. The different diagnoses studied were bacterial meningitis, pneumonia, viral meningitis, cerebral abscess, enteritis, erysipelas, viral encephalitis and neuroborreliosis. A serum S100B level > 0.15 microg/l was defined as increased. 57 patients were included in the study. S100B was elevated in 33% of patients (19/57). 73% (8/11) of patients with bacterial meningitis showed increased levels compared to 7% (1/14) of patients with viral meningitis. Viral encephalitis showed the highest mean S100B levels (mean 0.58 microg/l). 25% (6/24) of patients with extracerebral infections showed raised S100B levels. S100B levels were generally higher in patients with cerebral infections than in extracerebral infections. However, both false negative and false positive S100B levels were observed which may limit the use of S100B as a brain specific serum marker.
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PMID:Serum S100B levels in patients with cerebral and extracerebral infectious disease. 1500 May 52

The febrile young infant is commonly encountered in the emergency department, and the incidence of serious bacterial infection in these patients is as high as 15%. Undiagnosed bacterial infections such as meningitis and bacteremia can lead to overwhelming sepsis and death or neurologic sequelae. Undetected urinary tract infection can lead to pyelonephritis and renal scarring. These outcomes necessitate the evaluation for a bacterial source of fever; therefore, performance of a full sepsis workup is recommended to rule out bacteremia, urinary tract infection, and bacterial meningitis in addition to other invasive bacterial diseases including pneumonia, bacterial enteritis, cellulitis, and osteomyelitis. Parents and emergency clinicians often question the necessity of this approach in the well-appearing febrile young infant, and it is important to understand and communicate the evidence that guides the approach to these patients. Recent studies examining the risk of serious bacterial infection in young infants with bronchiolitis and the role of viral testing in the febrile young infant will also be discussed in this review.
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PMID:Evaluation of the febrile young infant: an update. 2397 Dec 72