Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0085383 (hypocapnia)
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Human Gene/Protein
Hb-1 10.0
SPAP 9.5
V4-6 9.1
beta-site APP-cleaving enzyme 9.0
Kir5.1 8.7
V1-3 8.2
P3 protein 8.1
CBF 7.9
DMO 7.7
CSR 7.5
SURF1 7.5
HSM 7.5
CO2 7.5
GF-1 7.3
PEN-2 7.2
Kir2.3 7.0
RPI 6.9
TNG 6.9
VAChT 6.9
Kir1.1 6.8
MAC 6.8
soluble adenylyl cyclase 6.6
ABP 6.6
Kir4.1 6.5
CPAP 6.5
syntaxin-4 6.5
EDRF 6.1
TLX 6.1
CBX 6.0
LBA 5.9
CSA 5.8
Alb 5.7
biliverdin reductase 5.7
nicastrin 5.7
EXP 5.6
CYP4A 5.6
Nle 5.5
WWOX 5.5
TCD 5.5
GCS 5.4
Tissue plasminogen activator 5.4
TASK-1 5.3
RYR1 5.2
FAC 5.2
IDO 5.2
Rett syndrome 5.2
AEC 5.2
PHP 5.2
CSB 5.2
AGE 5.2
CLP 5.2
swan 5.1
REM 5.1
DAC 5.1
Trio 5.0
OXPHOS 5.0
calmodulin-dependent protein kinase IV 5.0
carbonic anhydrase 5.0
AIP 5.0
Na+/H+ antiporter 4.9
mm-1 4.9
P50 4.9
HC1 4.9
PVR 4.7
IAP 4.7
pleiotrophin 4.7
OPD 4.7
Cytochrome P-450 4.7
vesicular acetylcholine transporter 4.7
RAP 4.6
brain) 4.6
APH 4.6
muted 4.6
INI1 4.6
T12 4.6
CCA 4.5
P60 4.5
SWS 4.5
adenosinetriphosphatase 4.5
CCP 4.4
FDP 4.4
PEF 4.4
DM2 4.4
CPB 4.4
adenyl cyclase 4.3
inward rectifier 4.3
CPT 4.2
PER 4.1
FPL 4.1
NTR 4.0
PCA 4.0
MAP 4.0
GPT 4.0
aryl hydrocarbon receptor 3.9
ICP 3.9
ASA 3.9
CO3 3.9
LPL 3.8
cAMP response element binding protein 3.8
MGC 3.8
P100 3.8
endothelin-1 3.8
CSF 3.8
MAX 3.7
Rod 3.7
CaMKII 3.7
Superoxide dismutase 3.7
pro-apoptotic protein 3.6
ROM 3.6
adenosine receptor 3.6
SAP 3.6
Bright 3.6
Parathyroid hormone 3.6
LAD 3.5
adrenomedullin 3.5
Bax protein 3.5
DM1 3.5
cardiac troponin I 3.4
CPK 3.4
BNP 3.4
Ins 3.4
parathormone 3.3
ANOVA 3.3
LIM 3.3
P14 3.3
HSC 3.3
DNA binding protein 3.3
P10 3.3
RAF 3.3
SCL 3.2
ANP 3.2
TMP 3.1
ACT 3.1
PGD2 3.1
Endothelin-1 3.1
MBP 3.1
hemoglobin 3.1
cyclooxygenase 3.1
ADH 3.1
BACE1 3.0
MRS 3.0
AVP 3.0
HCN 3.0
T10 2.9
ARF 2.9
LDH 2.8
CRH 2.8
penumbra 2.8
parathyroid hormone 2.8
Nanog 2.8
TRPV1 2.8
proximal tubule 2.7
endothelin receptor 2.7
isocitrate dehydrogenase 2.7
methemoglobin 2.7
OCT4 2.6
P21 2.6
cyclooxygenase 2 2.6
FEV 2.5
atrial natriuretic peptide 2.5
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Disease
Chronic hyperventilation 13.0
Sympathicotonia 12.2
Acute respiratory alkalosis 11.9
Progressive pulmonary hypertension 11.9
Pulmonary artery thrombosis 11.0
hyperventilation syndrome 11.0
alkalosis 10.5
Lymphocytic alveolitis 10.5
Central sleep apnea 10.3
Recurrent pulmonary embolism 10.1
hypophosphaturia 9.8
Arterial steal syndrome 9.8
anxiety attack 9.7
Amyopathic dermatomyositis 9.3
Cerebral hypoperfusion 9.0
carboxyhemoglobinemia 8.9
narcotic dependence 8.9
Flail chest 8.8
anthracosilicosis 8.6
Exercise-induced bronchospasm 8.5
Carotid body 8.5
Carotid body 8.5
Carotid body 8.5
respiratory acidosis 8.5
adaptation reaction 8.4
Nephropathia epidemica 8.2
Escherichia coli meningitis 8.1
Orthostatic intolerance 7.9
metabolic alkalosis 7.8
mountain sickness 7.7
Postoperative ileus 7.7
hypoplastic anemia 7.5
Ondine's curse 7.5
vascular dilation 7.5
Acute mountain sickness 7.4
Ondine's curse 7.4
phosphaturia 7.4
pH increased 7.2
Periventricular leukomalacia 7.0
Streptococcus pneumoniae meningitis 6.9
Diaphragm 6.8
hyperchloremia 6.7
hypo-osmolality 6.7
simple phobia 6.6
Fahr's disease 6.6
tetany 6.6
Exercise-induced asthma 6.5
pulmonary infarction 6.5
sleep apnea 6.5
lactic acidosis 6.4
moyamoya 6.4
parasympathomimetic 6.3
hypochloremia 6.3
raised intracranial pressure 6.3
MAC 6.2
derealization 6.2
Werdnig-Hoffmann disease 6.1
MIN 6.1
MIN 6.1
organic disease 6.1
laryngospasm 6.1
cerebral aneurysm 6.0
fat embolism 6.0
panic disorder 5.9
Brock 5.9
Brain stem 5.9
polycystic ovary syndrome 5.8
cerebral vasospasm 5.8
Airway obstruction 5.8
Schmidt 5.8
FHF 5.8
CSA 5.8
panic attacks 5.8
intracranial aneurysm 5.8
subclavian steal syndrome 5.6
coronary insufficiency 5.6
pulmonary edema 5.5
primary pulmonary hypertension 5.5
SWS 5.4
familial dysautonomia 5.4
gastrointestinal dysfunction 5.4
rheumatic mitral stenosis 5.4
cerebral ischemia 5.4
cor pulmonale 5.4
psychotic depression 5.3
hypertensive encephalopathy 5.3
bronchospasm 5.3
Leigh syndrome 5.3
neonatal asphyxia 5.2
adult respiratory distress syndrome 5.2
PHP 5.2
CSB 5.2
mitochondrial encephalomyopathy 5.2
acute pulmonary edema 5.1
pulmonary embolism 5.1
CSB 5.1
hysteria 5.1
hypernatremia 5.1
Rett syndrome 5.1
brain dysfunction 5.1
left ventricular failure 5.0
choreoathetosis 5.0
vascular obstruction 5.0
tracheomalacia 5.0
Bradley 5.0
febrile convulsions 4.9
hemoglobinuria 4.9
AIP 4.9
obstructive airway disease 4.9
subarachnoid hemorrhage 4.9
fetal hypoxia 4.9
AIP 4.9
phobia 4.8
sudden infant death syndrome 4.8
obstructive sleep apnea 4.8
diabetic ketoacidosis 4.8
fluid overload 4.8
epiglottitis 4.7
lactose intolerance 4.7
psychosomatic disorders 4.7
TCD 4.7
syndrome X 4.7
agoraphobia 4.6
Raynaud 4.6
delirium 4.5
DM2 4.4
brain disorder 4.4
hyperosmolality 4.4
arteriopathy 4.4
right heart failure 4.3
respiratory failure 4.3
emotional stress 4.3
hyaline membrane disease 4.3
mental handicap 4.3
pulmonary hypertension 4.3
hepatorenal syndrome 4.2
coma 4.2
mutism 4.1
congestive heart failure 4.1
coronary artery spasm 4.1
methemoglobinemia 4.1
upper respiratory infection 4.1
bronchopneumonia 4.0
PER 4.0
aspiration pneumonia 4.0
transient ischemic attack 4.0
PCA 4.0
ARF 4.0
sick sinus syndrome 4.0
thrombophlebitis 4.0
arteriovenous malformation 4.0
erythrocytosis 3.9
Addison's disease 3.9
hypoglycemia 3.9
ICP 3.9
sinus tachycardia 3.9
disorientation 3.9
Nairobi 3.9
mixed connective tissue disease 3.9
Addison's disease 3.8
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Symptom
hypocapnia 14.2
Convulsive movements 12.6
disintegration of the body 12.2
Central cyanosis 11.2
hypercapnia 10.1
hemiparesthesia 9.6
Periodic breathing 9.3
sighing 9.2
Orthostasis 9.1
CSR 9.0
Gasping 8.3
hyperoxia 8.2
tachypnea 7.3
breath holding 7.1
rales 6.9
frequent urination 6.8
sinus pressure 6.7
bradypnea 6.5
orthopnea 6.4
periorbital edema 6.2
non-productive cough 6.1
pleuritic chest pain 6.0
cyanosis 5.9
chest tightness 5.6
dyspnea 5.3
hypothermia 5.0
syncope 5.0
Fluctuation 5.0
presyncope 5.0
hypertonia 4.9
anesthesia 4.9
atypical chest pain 4.9
clonus 4.7
shortness of breath 4.4
clubbing 4.4
snoring 4.3
dry skin 4.2
hypersomnia 4.2
spasm 4.1
Hudson 4.1
hypoproteinemia 4.0
exhaustion 3.9
pallor 3.9
tingling 3.9
hemiplegia 3.8
respiratory distress 3.7
hunger 3.7
chest pain 3.6
dizziness 3.5
exertional dyspnea 3.5
numbness 3.4
oliguria 3.3
acute pain 3.2
hemoptysis 3.2
stridor 3.0
cough 3.0
wheezing 3.0
seizures 2.9
acidity 2.9
epigastric pain 2.4
analgesia 2.4
insomnia 2.4
fatigue 2.3
dysarthria 2.3
agitation 2.2
collapse 2.2
dystonia 2.2
sleepiness 2.1
chills 2.1
paresthesia 1.9
headache 1.7
lethargy 1.7
hepatomegaly 1.7
hypotonia 1.7
tinnitus 1.5
arthralgia 1.4
discomfort 1.3
weakness 1.3
nausea 1.3
vomiting 1.2
discomfort 1.2
distraction 1.0
erythema 0.5
functional recovery 0.5
anorexia 0.4
diarrhea 0.4
ataxia 0.2
pain 0.1
tremor 0.0
angina -0.2
overweight -0.5
Drug
Ultiva 10.9
Arfonad 9.2
LCBF 9.0
Arfonad 8.7
Dextropropoxyphene 8.2
Doxapram 7.6
Sodium acetate 7.5
Inderal 6.7
Thiopentone 6.5
Papaverine 6.3
Fenoterol 6.3
Magnesium sulfate 6.2
Sodium nitroprusside 5.3
Helium 4.9
CFS 4.9
Phosphatidylserine 4.8
Propofol 4.7
Camp 4.7
Lipiodol 4.5
SF6 4.4
Methylprednisolone 4.4
Phentolamine 4.0
Vitamin B 3.9
nitroglycerin 3.7
MgSO4 3.6
DM1 3.6
Award 3.4
NaI 3.4
NaI 3.4
NaI 3.4
CSF 3.4
NaI 3.4
Indomethacin 3.2
ACT 3.1
Clonidine 3.0
Fraction 2.9
MAP 2.8
ADM 2.6
Nephron 2.4
Asthma 2.4
Nephron 2.2
caffeine 2.1
Monit 2.1
Adriamycin 2.0
NADH 1.8
NH3 1.4
ROC 1.3
ABC 1.1
Ethanol 0.9
ampicillin 0.2
Cardiovasc -1.4
Enzyme
HVS 6.3
carbonic anhydrase 5.0
1-hydroxylase 5.0
endothelin-converting enzyme 4.9
beta-secretase 4.4
CPT 4.1
CPT 4.0
MAP 3.9
LPL 3.8
CPT 3.6
prostaglandin synthetase 3.4
CaMKII 3.2
ADH 3.1
isocitrate dehydrogenase 2.6
isocitrate dehydrogenase 2.4
urokinase-type plasminogen activator 2.4
phosphofructokinase 2.3
NO synthase 2.3
heme oxygenase 2.2
PAH 2.1
creatine kinase 2.0
glutamine synthetase 1.9
adenosine deaminase 1.9
adenosine deaminase 1.9
hexokinase 1.8
superoxide dismutase 1.7
kallikrein 1.6
AST 1.6
ACE 1.6
alanine aminotransferase 1.5
lipoprotein lipase 1.4
beta-glucuronidase 1.3
ATPase 1.2
xanthine oxidase 1.2
guanylate cyclase 1.1
lipoxygenase 1.1
cytochrome oxidase 1.1
catalase 1.0
alcohol dehydrogenase 1.0
monoamine oxidase 0.8
aspartate aminotransferase 0.8
renin 0.7
cholinesterase 0.6
acetylcholinesterase 0.4
phospholipase C 0.0
endonuclease 0.0
lipase 0.0
adenylate cyclase -0.0
protein kinase -0.5
lactate dehydrogenase -0.6
peroxidase -0.8
caspase-3 -0.9
focal adhesion kinase -1.2
alkaline phosphatase -1.4
protein kinase C -1.4
Compound
Desflurane 8.8
Clofilium 8.6
Methionine sulfoximine 8.3
W37 8.1
Mepivacaine 8.0
PGG2 8.0
phenylphosphonic acid 7.7
DMO 7.6
phenylphosphonic acid 7.6
Sodium acetate 7.5
HSM 7.5
Isoflurane 7.2
CO2 7.1
Thiopental 7.0
Xenon 7.0
20-HETE 6.9
Acetazolamide 6.8
Sufentanil 6.7
DPG 6.7
Nimodipine 6.6
SHB 6.5
N2O 6.5
Pancuronium 6.5
Mannitol 6.4
Mannitol 6.4
isopentane 6.3
Papaverine 6.3
phosphocreatine 6.2
DPG 6.2
Halothane 6.2
Ephedrine 6.1
Pentobarbital 6.1
Magnesium sulfate 6.1
Nitrofurantoin 6.0
Magnesium sulfate 6.0
carbonic acid 6.0
carbonic acid 6.0
carbonic acid 6.0
carbonic acid 6.0
carbonic acid 6.0
carbonic acid 6.0
carbonic acid 6.0
carbonic acid 6.0
carbonic acid 6.0
carbonic acid 6.0
carbonic acid 6.0
carbonic acid 5.9
carbonic acid 5.9
carbonic acid 5.9
carbonic acid 5.9
carbonic acid 5.9
Nicardipine 5.9
MCA 5.9
MCA 5.9
carbonic acid 5.9
carbonic acid 5.9
Etomidate 5.9
Phenylephrine 5.8
Remifentanil 5.7
Sevoflurane 5.7
ANI 5.7
Pentobarbital 5.7
Pyridoxine 5.6
Ketanserin 5.6
Emery 5.6
Nembutal 5.6
ethyl carbamate 5.6
Cereb 5.6
Clomipramine 5.6
D-gluconate 5.5
DLA 5.5
HfO2 5.5
carbonic acid 5.4
HCO 5.3
Leucovorin 5.3
Methacholine 5.3
AGE 5.2
carbonic acid 5.2
Aminophylline 5.1
DAC 5.1
APH 5.1
carbonate 5.0
ECS 5.0
TBI 4.8
Bicuculline 4.8
2,3-diphosphoglycerate 4.8
Phosphatidylserine 4.8
DDVP 4.7
CPP 4.7
Ins(1,4,5)P3 4.7
Physostigmine 4.6
CPP 4.6
Propofol 4.6
Ketamine 4.6
PGH2 4.5
Temozolomide 4.5
CPB 4.5
Methylprednisolone 4.5
Lactate 4.5
norleucine 4.4
SITS 4.4
Dexmedetomidine 4.4
Capsaicin 4.4
Tin 4.3
FDP 4.3
Nitroglycerin 4.2
Hypo 4.2
oxygen 4.2
CPT 4.2
TXA2 4.1
norleucine 4.1
Dipyridamole 4.1
Dipyridamole 4.1
Dipyridamole 4.1
Dipyridamole 4.1
Atorvastatin 4.0
CPT 4.0
Midazolam 4.0
GPT 4.0
DPH 3.9
POP 3.9
Propranolol 3.7
Prazosin 3.7
SO2 3.7
Nifedipine 3.7
BHT 3.6
MAP 3.6
CCP 3.5
Lac 3.4
Verapamil 3.4
HNO3 3.4
HNO3 3.4
HNO3 3.4
HNO3 3.4
HNO3 3.4
HNO3 3.4
HNO3 3.4
HNO3 3.4
HNO3 3.4
HNO3 3.4
HNO3 3.4
HNO3 3.4
HNO3 3.4
HNO3 3.4
HNO3 3.3
HNO3 3.3
HNO3 3.3
HNO3 3.3
HNO3 3.3
HNO3 3.3
HNO3 3.3
HNO3 3.3
HNO3 3.3
HNO3 3.3
BNP 3.3
HNO3 3.3
Indomethacin 3.3
Naloxone 3.3
HNO3 3.3
Verapamil 3.3
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