Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0085383 (hypocapnia)
 1,697 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In 18 patients with chronic uremia the effect of 4 hour hemodialysis on VC, FEV1, PEF, MEF25, MEF50, MEF75, PaO2 and PaCO2 were analysed. Significant falls in PaO2 and PaCO2 were found after ending the four hour long hemodialysis. Only nonsignificant changes in the other parameters were observed. The results of this study demonstrates the role of ventilatory disturbances of small airways in the pathogenesis of dialysis induced hypocapnia and hypoxemia.
Pneumonol Pol 1989 Mar
PMID:[Effect of hemodialysis on the functional status of small airways and partial pressure of oxygen and carbon dioxide in the blood of patients with chronic uremia]. 251 25

The purpose of this work was determination of the effect of physical exercise on maximal gastric output. The study was carried out in 21 men aged 20-56 years with chronic duodenal ulcer. The control group comprised 17 healthy men aged 20-28 years. During three successive hours the maximal acid output was determined at rest, during one-hour exercise on a cycle ergometer and during one-hour restitution. Gastric secretion was stimulated with pentagastrin administered subcutaneously in a dose of 6 mcg/kg at the beginning of each hour of the study. Besides that the parameters of acid-base equilibrium were determined before the beginning of resting MAO measurement, immediately after its completion, and then after one hour of exercise and one hour of restitution. Physical exercise caused in the group of patients a significant increase of MAO (p less than 0.001), which was due to increased volume of gastric juice (p less than 0.001) and the concentration of acid in it (p less than 0.02). During the restitution the value of MAO was significantly below that obtained at rest. On the other hand, in healthy subjects exercise caused a significant reduction of MAO value (p less than 0.005) as a result of decreased volume of gastric juice (p less than 0.005). During MAO determination at rest a rise was observed in the pH of blood, increased concentration of bicarbonates and base excess (p less than 0.05). During the exercise with further aspiration of gastric juice a further significant increase of pH and pO2 and reduction of pCO2 (p less than 0.05) was observed. Exercise caused in patients an increase of gastric secretion in contrast to healthy subjects. Changes in acid-base balance showed a tendency for metabolic alkalosis with hypocapnia, and were similar in both groups.
Pol Arch Med Wewn 1988 Jan
PMID:[Maximal gastric secretion during physical exertion and restitution in patients with chronic duodenal ulcer]. 327 64

We describe the case of a 61-year-old male patient, in which the search for the cause of chronic respiratory failure, severe pulmonary hypertension and secondary erythrocytosis resulted in a diagnosis of combined pulmonary fibrosis and emphysema (CPFE). This is a unique, recently characterised syndrome with upper-lobe emphysema and pulmonary fibrosis of the lower lungs. The cause is unknown, but one of the main risk factor remains smoking. The patient was a heavy smoker (over 40 pack-years). He complained of dyspnoea on exertion and cough. Physical examination revealed basal crackles and cyanosis. The patient had severe reduction in diffusing capacity, out of proportion to his lung volumes (DLCO 27% of predicted value, FEV1 2.95 l (100%), FVC 4.41 l (118%), FEV1/FVC (66%). The blood gas showed hypoxemia (pO2 37 mm Hg), hypocapnia and respiratory alkalosis. Diagnosis was based on chest computer tomography, which revealed upper lobe emphysema and lower lobe ground glass changes and honeycombing. Severe pulmonary hypertension (SPAP 80 mm Hg) was confirmed by echocardiography and right cardiac catherisation. The patient received long-term oxygen therapy, inhaled corticosteroid and Ca-blocker.
Pneumonol Alergol Pol 2009
PMID:[Combined pulmonary fibrosis and emphysema - case report and literature review]. 1946 58

Transcranial Doppler (TCD) enables indirect assessment of cerebral circulation by measurement of cerebral blood flow velocity. Stenosis and occlusion of cerebral vessels or cerebral vasospasm can be detected with this non-invasive method. Moreover, changes in cerebral blood flow velocity in response to hypercapnia or hypocapnia, exercise, temperature, orthostatic stress, visual and intellectual stimulation can be recorded and vasoreactivity or autoregulation mechanisms assessed. Migraine is considered to be a vasomotor disorder; its pathogenesis, however, is complex and requires further studies. TCD may help to detect mechanisms leading to migraine attack as well as during the attack and help to understand its pathophysiology. In this paper, the results of TCD examination in migraine patients in headache-free periods and during the attacks, in basal condition and during different stimulations, are presented. The influence of triptans on cerebral circulation is also described. Additionally, the role of TCD in diagnosis of patent foramen ovale in migraineurs is discussed.
Neurol Neurochir Pol
PMID:Transcranial Doppler evaluation in migraineurs. 1948 94