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Query: UMLS:C0085383 (
hypocapnia
)
1,697
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We evaluated the effects of
hypocapnia
on arterial oxygenation during induced hypotension with nitroglycerin (TNG) or
prostaglandin E1
(
PGE1
) in patients undergoing mastectomy. Of the 20 patients studied, 10 belonged to TNG group and 10 belonged to
PGE1
group. Mean arterial pressure during induced hypotension was maintained at 70% of the values observed before hypotension. A significant decrease in PaO2 was observed during hypotension under normocapnia (PaCO2 35-40 mmHg) in both groups. In addition, small but significant reduction in PaO2 from 128.5 +/- 23.7 mmHg to 122.5 +/- 25.5 mmHg in TNG group and from 129.9 +/- 11.9 mmHG to 116.7 +/- 15.6 mmHg in
PGE1
group were induced by
hypocapnia
(PaCO2 27-30 mmHg) during hypotension. These findings suggest that usual dose of TNG and
PGE1
might not or might partially inhibit hypoxic pulmonary vasoconstriction.
...
PMID:[Effect of hypocapnia on arterial oxygenation during induced hypotension]. 156 May 71
