Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0085383 (hypocapnia)
 1,697 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The oxygen-binding properties of Hb molecule are unchanged in the third trimester of normal pregnancy and in pregnancy complicated by slight iron-deficiency anemia. Hb affinity to oxygen in whole blood is formed under the effect of the three main ligands H+, CO2, and 2,3-DPH. The development of hypocapnia in pregnant women results in elevation of pH values, reduction of pCO2, increase of intraerythrocytic 2,3-DPH concentration by 15-18%. Variously directed effects of H+, CO2, and 2,3-DPH on Hb affinity to O2 result in normal P50 values and therefore the Hb-O2 dissociation curve is not shifted to the right. Thus, in pregnant women with alkalosis 2,3-DPH effect on Hb affinity to oxygen completely eliminates H+ and CO2 effects but not compensates for Hb deficiency in the blood.
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PMID:[Status of the oxygen transport system of hemoglobin in physiological pregnancy and pregnancy complicated by iron deficiency anemia]. 147 17

Examining the parameters of the blood oxygen-transport system and oxygen tissue balance in 71 patients with bronchial asthma (BA) and in 60 patients with BA concurrent with varying carbohydrate metabolic disturbances (CMDs) revealed differences in oxygen transport. In asthmatic patients without CMDs, the pattern of changes in oxygen balance permitted identification of arteriohypoxemic hypoxia. The high frequency of factors (alkalosis, hypocapnia) that enhance hemoglobin affinity for oxygen, which are compensated for by the increase in 2,3-DPH, as well as hypoxia of peripheral shunting are the specific features of impaired oxygen balance in asthmatic patients with concomitant CMDs that predispose to the development and progression of pulmonary hypertension and cor pulmonale which cause early disability. The determination of the leading link in impaired oxygen transport individualizes treatment approaches and provides evidence for a need for earlier use of metabolic and antihypoxic agents in asthmatic patients with CMDs.
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PMID:[The blood oxygen-transport system and oxygen tissue balance in patients with bronchial asthma (BA) concurrent with carbohydrate metabolic disturbances]. 1588 65