Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0085110 (SCID)
 11,041 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
severe combined immunodeficiency 3176
NOD 2266
Sep 701
cytokine 626
CD4 616
lymphoid 568
CD34 542
Mol 538
thymus 458
CD8 410
HLA 288
IFN-gamma 286
adenosine deaminase 261
IL-2 252
p53 200
interferon 189
IL-6 182
IL-4 181
CD45 176
X-linked 169
IFN 165
collagen 165
TCR 163
CD38 161
IL-10 157
insulin 153
CD44 144
DNA-dependent protein kinase 141
MHC 132
caspase-3 131
CXCR4 129
CD19 129
T cell receptor 126
CD133 118
chemokine 113
CD25 113
vascular endothelial growth factor 113
Adenosine deaminase 111
TNF 109
interleukin-2 108
tumor necrosis factor 105
TNF-alpha 100
urokinase-type plasminogen activator 98
gamma chain 96
VEGF 94
Bcl-2 90
osteogenic 90
p21 89
erythroid 89
IL-7 88
tyrosine kinase 85
interferon-gamma 85
PC-3 84
IgA 84
gut 83
RAG1 83
stem cell factor 82
THC 82
fibronectin 76
IgE 76
IL-15 73
CD20 73
fused 73
albumin 72
ICAM-1 72
IL-2 receptor 72
ADA 72
AKT 71
CD31 71
MAPK 70
HLA-DR 70
IL2RG 69
CD40 69
noggin 69
ERK 68
IL-8 66
CXCL12 66
thrombopoietin 65
MHC class II 64
RAG2 64
granulocyte 64
IL-3 63
glycoprotein 60
MHC class I 60
major histocompatibility complex 59
E-cadherin 59
OCT4 59
Fas 59
interleukin-6 58
mTOR 58
vimentin 57
natural killer cell 57
JAK3 56
PEG 56
CD28 55
PI3K 55
catenin 55
IL-17 54
CCR5 53
alkaline phosphatase 53
lipopolysaccharide 52
cyclin D1 51
androgen receptor 50
ATP 49
epidermal growth factor receptor 49
tumor necrosis factor alpha 48
Nanog 48
PC3 47
IL-5 47
thymidine kinase 46
CD24 46
c-kit 46
granulocyte colony-stimulating factor 45
TGF-beta 45
Cytokine 45
lectin 45
STAT3 44
HER2 44
c-Myc 43
PBS 43
CD56 43
c-myc 43
granulocyte-macrophage colony-stimulating factor 42
LPS 42
matrix metalloproteinase 42
cytokine receptor 42
ALL 41
GM-CSF 41
CSF 41
Raji 41
human leukocyte antigen 41
ERK1 41
Ki-67 41
perforin 41
hematopoietic stem and progenitor cells 41
lymphokine 40
osteosarcoma 40
mouse) 40
CD14 39
DBA 39
p38 38
CD11b 38
membrane protein 38
non-Hodgkin's lymphoma 38
colon carcinoma 37
adhesion molecule 37
survivin 37
CD30 36
AML 36
Thy-1 36
PARP 35
Jak3 35
EGFR 35
Daudi 35
hepatocyte growth factor 35
MRI 35
osteocalcin 34
caspase-9 34
Oct4 34
BCR 34
more...
Disease
SCID 11041
tumor 2512
NOD 2266
cancer 2122
tumor growth 849
immunodeficiency 724
leukemia 659
HIV 401
breast cancer 358
metastases 336
lymphoma 315
melanoma 265
tumorigenesis 253
prostate cancer 250
carcinoma 243
graft-versus-host disease 241
depression 215
Epstein 215
acute myeloid leukemia 205
multiple myeloma 204
diabetes 202
ADA deficiency 181
tumor progression 172
AIDS 165
adenocarcinoma 154
lung cancer 149
acute lymphoblastic leukemia 145
personality disorder 134
X-linked severe combined immunodeficiency 133
hepatocellular carcinoma 133
infectious diseases 133
lymphopenia 132
Leukemia 131
major depressive disorder 128
cytomegalovirus 125
virus infection 124
primary tumor 115
colitis 107
carcinogenesis 106
pancreatic cancer 100
Wiskott-Aldrich syndrome 100
immune deficiency 97
B-cell lymphoma 96
Hodgkin's disease 95
Infection 95
mental illness 94
anxiety disorders 94
colon cancer 94
Mycobacterium 93
chronic granulomatous disease 92
herpes simplex 88
MCF 88
rheumatoid arthritis 88
squamous cell carcinoma 85
pneumonia 85
arthritis 81
chronic myeloid leukemia 80
tuberculosis 80
ovarian cancer 77
colorectal cancer 76
Burkitt's lymphoma 73
type 1 diabetes 71
schizophrenia 70
viremia 68
autoimmune disease 66
glioma 65
posttraumatic stress disorder 63
neuroblastoma 60
suicide 59
glioblastoma 59
borderline personality disorder 58
varicella 58
inflammatory bowel disease 57
psychosis 56
ATM 55
anemia 54
tetanus 54
chronic lymphocytic leukemia 53
hypogammaglobulinemia 52
gastric cancer 51
plaque 49
sarcoma 49
non-small cell lung cancer 49
encephalitis 49
bipolar disorder 48
lung metastases 48
hepatitis 46
non-Hodgkin's lymphoma 46
tumor angiogenesis 46
chronic lymphocytic leukemia 46
hepatitis B 45
thrombocytopenia 45
asthma 45
systemic lupus erythematosus 45
X-linked agammaglobulinemia 44
solid tumor 44
panic disorder 44
ADA-SCID 44
teratoma 43
osteosarcoma 42
DBA 42
renal cell carcinoma 42
failure to thrive 41
DiGeorge syndrome 41
Lyme disease 41
affective disorder 41
hepatitis C 41
adult T-cell leukemia/lymphoma 40
alcoholism 39
psychopathy 39
epithelial ovarian cancer 39
neutropenia 38
dysplasia 38
fibrosarcoma 38
influenza 38
aggressiveness 37
lung carcinoma 37
leukemogenesis 37
hyperglycemia 37
malaria 36
candidiasis 35
EBV infection 34
sepsis 34
hematologic malignancies 34
aplastic anemia 33
lymphoproliferative disorders 33
sepsis 32
liver cancer 32
PHA 32
vaccinia 32
Kaposi's sarcoma 32
PCP 32
acute leukemia 32
obsessive-compulsive disorder 31
psoriasis 31
T-cell acute lymphoblastic leukemia 30
ABL 30
cervical cancer 30
Crohn's disease 29
bone disease 29
aggression 29
substance abuse 29
rash 29
B-cell lymphomas 29
Syndrome 28
malnutrition 28
cryptosporidiosis 28
brain tumor 27
lupus 27
substance use 27
liver metastases 27
agammaglobulinemia 27
myelodysplastic syndrome 26
eosinophilia 26
wasting 26
stomatitis 25
glioblastoma multiforme 25
mantle cell lymphoma 25
acute promyelocytic leukemia 24
multiple sclerosis 24
more...
Symptom
diarrhea 74
splenomegaly 30
pain 24
hepatosplenomegaly 20
seizures 15
starvation 15
cachexia 13
functional recovery 12
fatigue 11
anorexia 11
respiratory distress 10
ataxia 9
alexithymia 9
weakness 9
exhaustion 9
cough 8
Depressive symptoms 7
hopelessness 6
headache 6
collapse 6
agitation 6
anesthesia 5
tremor 5
spasticity 5
dyspnea 4
dystonia 4
hepatomegaly 4
erythema 4
vomiting 4
insomnia 4
hypotonia 4
discomfort 4
lethargy 4
pelvic pain 4
tachypnea 3
Positive and Negative Symptoms 3
nausea 3
myalgia 3
Scratch 3
stigma 3
bone pain 3
paresis 3
hypothermia 3
tinnitus 3
dizziness 3
HSA 3
torticollis 3
asthenia 2
Involuntary Movement 2
mental fatigue 2
abnormal gait 2
thinning 2
back pain 2
neuralgia 2
skin damage 2
chest pain 2
overweight 2
apathy 2
adenitis 2
rhinorrhea 1
sleepiness 1
elevated mood 1
acute stress 1
discomfort 1
blackout 1
emaciation 1
distraction 1
facial pain 1
hyperoxia 1
analgesia 1
flushing 1
orofacial pain 1
BHS 1
hemiplegia 1
abdominal pain 1
atypical chest pain 1
twitching 1
cancer pain 1
hypercapnia 1
cerebellar ataxia 1
personality change 1
shortness of breath 1
rigors 1
polydipsia 1
sneezing 1
paraparesis 1
No pain 1
decreased appetite 1
Tenderness 1
colic 1
Opisthotonus 1
spasm 1
Gastrointestinal symptoms 1
swollen joints 1
No adverse effect 1
nasal discharge 1
pallor 1
Joint hypermobility 1
Decreased activity 1
cyanosis 1
hypertonia 1
Neuropathic pain 1
abiotrophy 1
DNA marker 1
Drug
IFN-gamma 276
IL-2 253
Dermatol 90
CSF 78
uPA 73
Adenosine deaminase 64
Norplant 63
G-CSF 26
lysine 25
Asthma 24
CTX 19
G418 19
ROS 18
BCG vaccine 16
IFN-beta 15
Spectrum 12
-deoxyadenosine 12
Taxol 12
AZT 11
AZT 11
Adriamycin 10
Herceptin 10
ROC 10
Rituximab 9
Cardiovasc 9
p75 9
CPT-11 9
CTX 8
CTX 8
Bortezomib 8
DM1 8
Bevacizumab 8
Spectrum 8
Docetaxel 8
IL-11 7
ABC 6
MRC 6
anti-CD33 6
CAM 6
MDS 6
Sorafenib 5
Gel 5
NVP 5
NaI 5
Check 5
NaI 5
EE2 5
NaI 5
ADM 5
ETS 5
Vinorelbine 5
Imatinib 5
NaI 5
ETA 5
R1881 4
ascorbate 4
Campath 4
Deoxyadenosine 4
NADH 4
Lenalidomide 4
Heme 4
Campath 4
Albumin 4
Gelatin 4
PDL 4
RFP 4
Taxotere 4
Meth 4
TAT 4
IL-1ra 4
Cidofovir 4
NBT 4
Genasense 3
Gleevec 3
caffeine 3
Navelbine 3
Itraconazole 3
Erlotinib 3
HPMPC 3
vitamin E 3
Leaf 3
Natalizumab 3
MAP 3
Arsenic trioxide 3
Everolimus 3
Alliance 3
TRM 3
Acyclovir 3
PTC 3
TEL 3
Simvastatin 3
PCP 3
9-THC 2
TAC 2
ENT 2
VCR 2
Gefitinib 2
Doxycycline 2
ACT 2
ddI 2
Anakinra 2
Clopidogrel 2
Gelfoam 2
Hypaque 2
Activin 2
Rosiglitazone 2
Trib 2
Alanine 2
Photofrin 2
AraC 2
Glucagon 2
Pegademase bovine 2
Areca 2
Cetuximab 2
ATV 2
BLM 2
Fragment 2
Fluconazole 2
Aloe 2
Oxaliplatin 2
Omeprazole 2
Hypaque 2
ALA 2
Fluorescein 2
Nitazoxanide 2
CFS 2
KGF 2
Forskolin 2
Resovist 2
ADR 2
DEL 2
Glutathione 1
Magnevist 1
Lumiliximab 1
PFA 1
Posture 1
Iomeprol 1
Cremophor EL 1
DEX 1
CDX 1
2-Methoxyestradiol 1
CIA 1
MDM 1
CDP 1
PMPA 1
Piclamilast 1
Truvada 1
lactose 1
TTC 1
Indocyanine green 1
Monit 1
Caramel 1
NAG 1
CCL 1
Zoledronic acid 1
Onconase 1
Methylcellulose 1
Loxoribine 1
Batimastat 1
Portal 1
more...
Enzyme
adenosine deaminase 265
ERK 262
adenosine deaminase 261
focal adhesion kinase 223
mitogen-activated protein kinase 151
luciferase 119
caspase-3 106
aldehyde dehydrogenase 103
urokinase-type plasminogen activator 102
protein kinase 69
alkaline phosphatase 53
reverse transcriptase 50
thymidine kinase 46
BMT 44
beta-galactosidase 40
PARP 39
proteasome 34
APC 34
MEK 33
aldehyde dehydrogenase 33
P-glycoprotein 32
aldehyde dehydrogenase 31
ricin 31
aldehyde dehydrogenase 31
aldehyde dehydrogenase 31
caspase-9 30
RNase 27
protein kinase C 25
RNase 25
CD10 23
CD13 23
firefly luciferase 21
RNA polymerase 21
ALDH 19
caspase-8 19
prostate-specific antigen 18
peroxidase 17
collagenase 16
granzyme B 16
thyroid peroxidase 16
NO synthase 16
endonuclease 15
alanine aminotransferase 15
phosphatidylinositol 3-kinase 15
lactate dehydrogenase 15
deaminase 15
purine nucleoside phosphorylase 15
calcineurin 14
transcriptase 14
catalase 13
phosphoglycerate kinase 13
MIP 13
MDR 12
AMP-activated protein kinase 12
prostate-specific membrane antigen 12
IKK 11
trypsin 11
ACS 11
thrombin 11
DNA polymerase 10
DNA methyltransferase 10
cdc2 10
GSK 10
Thy1 10
glutathione S-transferase 10
NOS 9
superoxide dismutase 9
aspartate aminotransferase 9
MMP 8
phosphoinositide 3-kinase 8
asparaginase 8
topoisomerase 8
matrix metalloproteinase 2 8
ribonuclease 8
caspase-1 8
ribonuclease 8
ATPase 8
lysozyme 7
ribonucleotide reductase 7
5'-nucleotidase 7
ribonucleotide reductase 7
topoisomerase 7
phosphodiesterase 6
dihydrofolate reductase 6
neuraminidase 6
beta-glucuronidase 6
dipeptidyl peptidase IV 6
glyceraldehyde-3-phosphate dehydrogenase 6
CYP3A4 6
GAS 6
TdT 6
dihydroorotate dehydrogenase 5
furin 5
phospholipase C 5
dihydroorotate dehydrogenase 5
neutrophil elastase 5
matrix metalloproteinase 9 5
thymidylate synthase 5
thromboplastin 5
cathepsin B 5
DNA ligase 5
DNA ligase 5
tyrosinase 5
arginase 4
adenosine kinase 4
PDE 4
dihydropyrimidine dehydrogenase 4
TAT 4
AST 4
glutathione peroxidase 4
AMPK 4
transglutaminase 4
chymase 4
cathepsin K 4
DNase 4
urease 4
hypoxanthine-guanine phosphoribosyltransferase 4
ACE 4
guanylate cyclase 4
heme oxygenase 4
urease 3
deoxycytidine kinase 3
ornithine transcarbamylase 3
TSP-1 3
histone demethylase 3
MAP 3
p80 3
nitrate reductase 3
acid phosphatase 3
PCP 3
lipase 3
cytosine deaminase 3
caspase-4 3
elastase 3
nitrate reductase 3
alpha-L-iduronidase 3
nitrate reductase 3
glyceraldehyde-3-phosphate dehydrogenase 3
indoleamine 2,3-dioxygenase 3
nitrate reductase 3
chalcone synthase 3
nitrate reductase 3
nitrate reductase 3
glutamine synthetase 3
PDK1 3
glucose-6-phosphate dehydrogenase 3
NADPH oxidase 3
HIV-1 protease 3
renin 3
tyrosine hydroxylase 3
NADPH oxidase 3
dihydropyrimidine dehydrogenase 3
plasmin 3
caspase-2 2
aldehyde oxidase 2
beta-lactamase 2
Alternating 2
UDP-glucuronosyltransferase 2
S1 nuclease 2
caspase-4 2
more...
Compound
DNA 872
Dec 802
Clin 770
DSM 450
MDA 177
oxygen 120
glucose 117
TNF 109
tyrosine 99
phosphate 92
calcium 90
PEG 90
water 89
PEG 71
GM1 53
arginine 51
ATP 49
retinoic acid 49
DBA 45
BCG 43
DBA 39
MTT 39
DBA 39
methionine 38
sodium 38
cysteine 37
sulfate 37
lysine 37
BCR 34
LTC4 33
His 33
acetate 33
serine 33
nitrogen 31
ABL 30
nitric oxide 29
tryptophan 29
alanine 28
leucine 27
zinc 26
iodine 26
ethanol 25
iron 25
MEK 24
threonine 24
ADP 23
urea 21
Insulin 20
CTX 19
ADP 18
5-FU 18
ADP 18
Adriamycin 18
salt 17
Optimal 17
cAMP 17
dUTP 16
Gly 16
AMP 16
Asp 16
pyrimidine 16
pyrimidine 16
FK506 15
ADR 15
Neo 14
galactose 14
Phe 14
Collagen 14
dATP 14
THP 13
THP 13
NKT 13
GTP 13
Adenosine 13
creatinine 12
pyrene 12
Hoechst 33342 12
MDR 12
AZT 12
ASA 12
proline 12
ACS 11
PID 11
diacetate 11
tryptophan 11
TCP 11
TCP 11
MIA 11
boron 11
SDS 11
TCP 11
Paclitaxel 11
ACS 11
PID 11
bromide 11
TCP 11
PAP 10
PAP 10
PAP 10
Pac 10
PAP 10
glutamine 10
MTS 10
PMA 10
Cyclosporine 10
PGE 10
nicotinamide 10
CPT-11 9
Curcumin 9
SCC 9
GSH 9
Androgen 9
GSH 9
GMP 9
glutamate 9
PDQ 9
tryptophan 9
DMSO 9
anthracene 9
ADP-ribose 9
CO2 9
fluorine 9
Interleukin-2 9
Rapamycin 9
tryptophan 9
potassium 8
PGA 8
HPC 8
TEM 8
HPC 8
Estrogen 8
glycerol 8
DDP 8
H2O2 8
hydrogen 8
TEC 7
PMA 7
ALP 7
ammonium 7
homocysteine 7
Thyroid 7
Gemcitabine 7
Gemcitabine 7
glutamic acid 7
STZ 7
NH2 7
5-HT 7
vitamin D 7
COS 7
copper 7
titanium 6
silicon 6
Hematoxylin 6
Nicotine 6
CES 6
Dexamethasone 6
TBI 6
Tanshinone 6
Estradiol 6
BCNU 6
more...