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Query: UMLS:C0085110 (SCID)
 11,041 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Candida albicans is a commensal fungus that commonly colonizes human mucosal surfaces. When the host immune defenses are impaired, C. albicans triggers recurrent infections of the oral mucosa and tongue. We previously reported that the characteristics in NOD/SCID. e2f1(-/-) mice that have naturally decreased saliva and T and B cells that do not develop increase the susceptibility of oral bacterial infection in the oral cavity. Next, we sought to establish a C. albicans infection model in NOD/SCID. e2f1(-/-) mice. C. albicans yeast forms were introduced by wiping a cotton swab moistened with C. albicans solution on the tongue after disinfection by 0.2 Chlorhexidine for the first time. After an interval of 60 min, the inoculation was performed by pipette 2 or 4 times at an interval of 60 min. The number of C. albicans colonized on the tongue significantly increased but there were no significant difference between NOD/SCID. e2f1(+/+) mice and NOD/SCID. e2f1(-/-) mice at 120-240 minutes. However, a significant difference between these mice was observed at 24 hours after the last inoculation. Moreover, 5 inoculations/day were also performed for 2-4 days and significant differences between mice arose, and the maximum level of infection was found at 24 hours after consecutive inoculation for 3, 4 and 5 days, but the levels were reduced after 48 h. It is suggested that the saliva volume and flow are important for preventing 24-hour colonization of C. albicans. NOD/SCID. e2f1(-/-) mice are a relevant mouse model for 24-hour colonization on the tongue.
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PMID:[An investigation of oral colonization by Candida albicans in immunodeficient animal with decreasing saliva volume]. 2481 65

Candida albicans is a commensal fungus that commonly colonizes as opportunistic pathogens human mucosal surfaces. Our aim was to observe persistent infection of C. albicans on the tongue in NOD/SCID.e2f1(-/-) mice, which naturally was decreased saliva and undeveloped T and B cells. Using a cotton swab, a C. albicans suspension was applied to the tongue of wild type and mutant mice after disinfection using 0.2% Chlorhexidine (CHX). In our earlier report, it was found that many times inoculation per day and consecutive day inoculations without disinfection of indigenous microorganisms did not induce significant C. albicans infection for 48 h in the oral cavity. In this study, using inoculation of four sets {one inoculation after disinfection by CHX + interval (3 or 4 d)} induced longer term and higher numbers infection for 4 days on the tongue than results in a previous report in both NOD/SCID.e2f1(+/+) and NOD/SCID.e2f1(-/-) mice. Repeat of disinfection to indigenous microorganisms and inoculation with interval established and realized a new model for persistent infection of C. albicans yeast. However, decreased saliva and consecutive inoculations per day did not contribute to the persistent colonization on the tongue in the mice. It is suggested that the interaction between C. albicans and indigenous microorganisms is important for persistent colonization of C. albicans yeast on the tongue rather than decreased saliva in the oral cavity.
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PMID:Persistent colonization of Candida albicans yeast on the tongue in NOD/SCID.e2f1-/- mice. 2564 May 31