Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0079731 (
B-cell lymphoma
)
16,671
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Germinal center (GC) B cells surge in their proliferative capacity, which poses a direct risk for B cell malignancies. G1- to S-phase transition is dependent on the expression and stability of D-type cyclins. We show that
cyclin D3
expression specifically regulates dark zone (DZ) GC B cell proliferation. B cell receptor (BCR) stimulation of GC B cells downregulates
cyclin D3
but induces c-Myc, which subsequently requires
cyclin D3
to exert GC expansion. Control of DZ proliferation requires degradation of
cyclin D3
, which is dependent on phosphorylation of residue Thr283 and can be bypassed by
cyclin D3
T283A
hyperstabilization as observed in
B cell lymphoma
. Thereby, selected GC B cells in the light zone potentially require disengagement from BCR signaling to accumulate
cyclin D3
and undergo clonal expansion in the DZ.
...
PMID:Cyclin D3 Governs Clonal Expansion of Dark Zone Germinal Center B Cells. 3320 94
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