Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0079731 (B-cell lymphoma)
 16,671 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Two cases of Richter's syndrome are reported (in a 62 and 64 years old man) consistent with the appearance of B cell lymphoma of high malignancy in the course of CLL (low malignancy B cell lymphoma). In one patient, after 8-, and in the other one--after 53 months since the diagnosis of CLL, there was rapid clinical deterioration with lymphadenopathy, hepato- splenomegaly, fever and progressive cachexia, anemia and thrombocytopenia and leukopenia, unrelated to treatment. Both patients died, 4 and 3 months respectively, since the appearance of these symptoms. In the first cases Richter's syndrome was diagnosed histopathologically from the autopsy material. In the liver, spleen, adrenals and bone marrow, in addition to the characteristic infiltrates of CLL (small lymphocytes) there were areas of large cell proliferation consistent with high malignancy lymphoma. In the other case, the infiltrates of large cell lymphoma were found in the gall bladder removed because of acute cholecystitis, and in the lymph node from the hepatic hilar area. Immunocytochemical studies performed on the biopsy material indicated that the neoplastic cells had markers of B lymphocytes and cytoplasmic IgM kappa, as lymphocytes of CLL. In patients with CLL, who display rapid clinical deterioration and general symptoms with cachexia, the possibility of Richter's syndrome should be considered, and appropriate morphological studies performed.
Acta Haematol Pol 1991
PMID:[2 cases of Richter's syndrome]. 182 59

A case is presented of primary, pulmonary B-cell lymphoma imitating bronchocentric granulomatosis. The initial manifestations were of multiple, pulmonary nodules, without intra- and extrathoracic lymph node, bone marrow and spleen involvement. Despite the initial removal of the affected pulmonary tissue the progression of the disease led to additional immunohistochemical evaluation of the resected tissue and final diagnosis. The authors also carry out a differential diagnosis of the reported changes.
Pneumonol Alergol Pol 1991
PMID:[A case of B-cell lymphoma imitating bronchocentric granulomatosis]. 184 37

A 45-year-old woman with T-cell lymphoma is reported. Enlargement of the peripheral lymph nodes was not observed. Splenectomy was performed for hypersplenism and during the operation the mesenteric and retroperitoneal lymph nodes were found to be greatly enlarged. Three years after the diagnosis of lymphoma malabsorption syndrome developed. After 5 years sudden clinical deterioration appeared, with loss of reaction to effective treatment given as yet. Conversion of the predominating lymphocyte subpopulation from T to B cells was observed owing to repeatedly done monitoring of peripheral blood lymphocytes. The pattern of the newly developed lymphoma was that of a highly malignant B-cell proliferation. The possible mechanisms of the conversion discussed by the authors include: simultaneous proliferation of B and T populations of lymphocytes, B-cell lymphoma induction by chemotherapy, and infection by Epstein-Barr virus.
Acta Haematol Pol
PMID:[Transformation of type T lymphoma into type B lymphoma]. 697 55

A synchronous presentation of an adenocarcinoma and a primary low grade B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) in the stomach is reported in a 73-year-old woman and a 55-year-old man. The diagnosis was based on microscopic examination of surgical specimens with immunohistochemistry. A possible etiology of the simultaneous presence of these two neoplasms in the stomach is discussed on the basis of our own material and review of the literature.
Pol J Pathol 1997
PMID:Synchronous carcinoma and primary MALT-lymphoma of the stomach. A report of two cases. 920 Sep 62

A 65 year old man with low grade malignant B cell lymphoma developed bilateral chylothorax, which reached the volume of 52.1. Chylothorax arised most probably as a result of pleural infiltration in the course of the disease. Chemotherapy and repeated drainage of chylus was successful. The resolution of massive bilateral chylothorax in our patient shows, that conservative measures (chemotherapy and repeated pleural drainage) should be tried even in very extensive chylothorax in the course of neoplastic disease.
Pol Arch Med Wewn 1999 Jun
PMID:[A case of massive chylothorax during the course of malignant lymphoma]. 1075 39

A case of 51 years old woman with 12-years history of rheumatoid arthritis and secondary Sjoegren's syndrome, who developed EBV-associated diffuse large B-cell lymphoma (Lymphomatoid granulomatosis type) involving lungs, lymph nodes and bone marrow was described.
Pneumonol Alergol Pol 2000
PMID:[Lung changes during the course of non-Hodgkin's lymphoma in a patient with rhematoid arthritis with secondary Sjogren's syndrome]. 1100 66

We describe 4 cases of non-Hodkin's lymphomas that were interesting because of their curiosal clinical courses and spontaneous complete remissions during the course of high malignancy lymphoma. We present three of them for the first time in Poland. Case 1: a 61-year old woman was admitted to the hospital because of the headache, lasting for 4 months before hospitalization and right hemiparesis. CT scans revealed the presence of tumor in the temporo-occipital region. The diagnosis of B-cell lymphoma was established at histopathological examination of the postoperative material. Co60--therapy of these region was applied after the operation with good response. Case 2: a 38-year woman was admitted to the hospital because of L5-S1 spondylolisthesis to operate it. During the hospitalization haemolytic anaemia of unknown origin, thrombocytopoenia, splenomegaly, fever and rising acute insufficiency of kidneys, heart, liver and CNS were occurred. The patient died, despite applying corticosteroidotherapy. The diagnosis of intravascular lymphoma was established at postmortem examination. Case 3: a 51-year old woman was admitted to the hospital with diagnosis: anaplastic non-Hodgkin lymphoma B-cell type high malignancy established after the double histopathological examination of lymph nodes and biopsy of the lung. At the admission to the Department of Haematology we stated absolute regression of these changes. The patient had been only observed in the Outpatient Department over 1 year. She died after 6 months since the beginning of the relapse despite intensive chemotherapy. Case 4: a 43-year old man was admitted to the hospital because of great hyperleukocytosis, hepatosplenomegaly and neurological symptoms. The diagnosis: chronic prolymphocytic leukaemia was established. The cerebrospinal fluid examination showed presence of mononuclears which infiltrated CNS. CT scans of the brain revealed leucaemic infiltrations of the hemispheres and cerebellum. The patient died despite intensive therapy due to rising progressive multiorgan failure.
Pol Arch Med Wewn
PMID:[Unusual cases of non-Hodgkin's lymphomas--case reports]. 1123 49

Gastrobiopsy specimens obtained from 15 patients, in whom gastroscopy examination pointed to gastric cancer and primary gastric lymphoma was later diagnosed in surgical material after gastrectomy, were immunostained using the anti MIB-1 antibody to assess the proliferative index. A control study was carried out on representative surgical specimens from these patients and on 10 gastrobiopsy specimens from patients in whom histopathology revealed moderate/severe gastritis. The proliferative activity was assessed with respect to the type of lymphoma (primary gastric marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue MALT type vs. diffuse large B-cell lymphoma) and stage of the lymphoma, and we compared the proliferative indices between inflammatory infiltrate and lymphoma cells. There were significant differences in the proliferative indices between inflammatory infiltrate and lymphoma cells, with immunohistochemical reactivity for MIB-1 antigen being visible even in the case of markedly mechanically damaged (crushed) gastrobiopsy material and accompanying necrosis. There were also differences in the proliferative indices between the groups of lymphomas varying in stage, although without statistical significance. There were no statistical differences in the rate of proliferation between lymphomas varying in "malignancy". The present results argue for the auxiliary role of the assessment of proliferative activity in gastrobiopsy material facilitating differentiation between inflammatory infiltrate and neoplastic infiltrate, especially in cases where mechanical damage or necrosis do not allow for precise histopathological evaluation.
Pol J Pathol 2001
PMID:Evaluation of the proliferative activity as an adjuvant helpful tool in the diagnosis of primary gastric lymphoma in gastrobiopsy. 1191 82

We report 39 years old man with the history of chronic sinusitis and rhinitis. After tooth extraction he gradually developed unilateral proptosis with ophtalmoplegia and visual loss caused by retroorbital mass which was related to destruction of the adjacent orbital walls, sinuses and base of the skull. During the following month the progressing lung nodules with mediastinal and hilar lymphadenopathy, macular skin lesions, renal insufficiency with proteinuria and anaemia appeared. The diagnosis of Wegener's Granulomatosis (WG) was formed on the base of clinical features and result of pathologic examination of surgical specimen from the paranasal sinuses. The progressive course under the standard immunosuppressive therapy required reevaluation of histologic slides, which resulted with the diagnosis of diffuse large B-cell lymphoma confirmed by the immunohistochemical staining. Administration of CHOP regimen resulted in spectacular regression of all of lesions.
Pneumonol Alergol Pol 2002
PMID:[Diffuse large B-cell lymphoma mimicking Wegener's granulomatosis]. 1227 68

The study involved 51 patients with histopathologically verified diagnoses of primary mediastinal large B-cell lymphoma (PMBL). Clinically they presented as the anterior mediastinal tumours, frequently with the superior vena cava syndrome (21 patients) and usually (in 42 out of 51) without involvement of other locations. Morphologically the tumours were very pleomorphic. Histopathologically they were composed of germinal center cells, clear cells or polymorphic cells of various size and shape. However, there were also PMBLs composed of cells resembling Reed-Sternberg and Hodgkin cells and small cells. Various types of stromal sclerosis were evident in most biopsies. Due to lymphoma patterns mimicking other tumours with primary or secondary mediastinal location it was necessary to use a panel of immunocytochemical stains. CD20 staining proved to be indispensable for distinguishing PMBL. The patients were treated with CHOP or MEVA (V-VIII courses) followed by radiotherapy of the mediastinum (3600-4200cGy/t). Complete remission was obtained in 21 patients with overall survival ranging from 36 to 99 months. A total of 24 patients are alive, 3 of them live with persisting disease. One patients was lost to follow up, 26 died despite the treatment due to persistence of mediastinal tumour or dissemination to distant organs.
Pol J Pathol 2002
PMID:Primary mediastinal large B-cell lymphoma is an important differential among mediastinal tumours. 1247 16


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