Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0079731 (B-cell lymphoma)
 16,671 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Primary cardiac non-Hodgkin's lymphoma is defined as being exclusively located in the heart and/or pericardium, and is extremely rare. This disease occurs mainly in immunocompromised patients and rarely in the immunocompetent. To date, 35 cases of primary cardiac non-Hodgkin's lymphoma have been reported in the literature by Chalabreysse et al in 2002, and 22 of these cases were diffuse, large B-cell lymphoma (DLBCL). We report a rare case of an immunocompetent female with no significant medical history who presented with dyspnea, chest pain and the beginnings of an SVC syndrome. The patient was initially diagnosed with primary cardiac Burkitt's lymphoma when surgical pathology was reviewed. After further investigation by another pathology lab, the tumor was defined as DLBCL, which was confirmed by fluorescence in situ hybridization techniques.
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PMID:Primary cardiac diffuse, large B-cell lymphoma in an immunocompetent patient. 1825 82

Prior to the introduction of rituximab, primary mediastinal B-cell lymphoma (PMBCL) had high rates of treatment failure with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP), prompting the use of consolidative mediastinal radiation or more intensive chemotherapy regimens. Cure rates improved dramatically with rituximab, but mediastinal radiation was still commonly employed with R-CHOP. We performed a retrospective review of patients treated with R-CHOP alone without radiation for PMBCL. Of 43 patients with PMBCL, 16 received R-CHOP alone. High-risk factors included 56% with bulky disease, 75% with elevated LDH, 25% with SVC syndrome, and 13% with stage IV disease. Three-year progression-free survival (PFS) and overall survival (OS) were 93% and 100% respectively. These results suggest that R-CHOP alone has a high cure rate in PMBCL while avoiding the side effects of mediastinal radiation.
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PMID:R-CHOP without radiation in frontline management of primary mediastinal B-cell lymphoma. 3073 60