Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0079731 (
B-cell lymphoma
)
16,671
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Computed tomography (CT) is currently the most commonly tool used for staging malignant lymphoma at diagnosis and restaging the disease after treatment. However functional imaging and mainly the 18-F-fluoro-2-deoxyglucose positron emission tomography (PET) outperforms CT in 18-FDG avid lymphomas. PET is now included in the new international response criteria and allows a better assessment of remaining residual mass after treatment. Early
TEP
result is an independent prognosis factor in diffuse large
B cell lymphoma
and Hodgkin lymphoma. Ongoing clinical trials are now testing risk adapted strategies based on early
TEP
results in these two lymphoma subtypes.
...
PMID:[Diagnostic imaging of lymphomas]. 2022 12
Primary intravascular large
B cell lymphoma
(IVL) remains a diagnostic challenge because of non-specific clinical, laboratory and imaging findings. The aim of the study was to analyse the major characteristics of IVL with uterine involvement. We retrospectively collected features of IVL with uterine involvement that was proven histologically or demonstrated by significant
18
FDG uptake on
18
FDG-PET/CT. Findings were compared to a comprehensive literature review. Five patients were identified. All of them were admitted for fever of unknown origin (FUO), with haemophagocytic lymphohistiocytosis in three cases. None had gynaecological symptom, contrasting with the literature data. Structural imaging (including whole-body CT scan and pelvic RMI) failed to yield any diagnosis.
18
FDG-PET/CT showed intense uterine uptake in all cases. Endometrial biopsy was performed in three cases and was positive in one. Diagnosis was obtained from coelioscopic iliac adenopathy biopsy in one case and from total hysterectomy in another. Punch biopsy of skin lesions led to diagnosis in the two remaining cases. Bone marrow biopsy was normal in all cases. Clinicians should be aware of potential isolated uterine involvement in IVL, especially in elderly women with FUO. Normal structural imaging does not rule out the diagnosis and
18
FDG-
TEP
/CT should be performed to guide high-yielding biopsy.
...
PMID:Uterine intravascular lymphoma as a cause of fever of unknown origin. 2885 31
