Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0079731 (B-cell lymphoma)
 16,671 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The autoimmune lymphoproliferative syndrome (ALPS) and ALPS-like syndrome are variable clinical conditions characterized by lymphoproliferative disease, autoimmune cytopenias and susceptibility to malignancy. A 59-year-old woman was admitted to the hospital for intractable generalized pain and stiffness with multiple swollen joints for 2 weeks. A low-grade fever, intermittent hypotension and confusion were associated with the pain. The evaluation revealed multiple joint bony erosions with effusion and a ruptured Baker's cyst and positive AFB testing on the joint biopsy of the right wrist. In addition, there were a macular skin rash with telangiectasia and perivascular lymphocyte infiltration, a cytopenia without abnormal cells, a hepatosplenomegaly, a pericardial thickness with effusion and pleural effusion. The patient was treated with anti-mycobacterial drugs, NSAIDs and glucocorticoids for 10 months. But with the symptoms worsening, the patient developed cervical lymph node enlargements and was diagnosed as a diffuse large B cell lymphoma with hemophagocytosis on biopsy.
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PMID:Autoimmune lymphoproliferative syndrome-like syndrome presented as lupus-like syndrome with mycobacterial joint infection evolved into the lymphoma. 1882 Sep 32

A 62-year-old male presented with generalized aches and pains accompanied by night sweats and weight loss. Clinical examination was unremarkable and the chest X-ray was reported as normal. Subsequent computed-tomography thorax and bone marrow aspirate diagnosed a diffuse large B-cell lymphoma. Prior to commencing chemotherapy, a routine echocardiography proved technically difficult and reported abnormal ventricular function. Following a cardiology review, a cardiovascular magnetic resonance scan was requested which demonstrated congenital absence of the pericardium and a normal ventricular function. The patient was asymptomatic and therefore continued on to chemotherapy treatment for the large B-cell lymphoma. <Learning objective: Congenital complete absence of the pericardium (CCAP) is a rare condition that often presents atypically and is detected incidentally. Multi-parametric, non-invasive cardiac imaging such as cardiovascular magnetic resonance imaging is the gold-standard diagnostic tool. CCAP is usually asymptomatic and does not require any surgical intervention. However, symptomatic patients who may be at risk of serious complications require surgical treatment such as pericardiotomy or pericardioplasty. Routine investigations such as the electrocardiogram, the chest X-ray, and the echocardiography may raise clinical suspicions of CCAP as demonstrated in this case report.>.
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PMID:Complete congenital absence of the pericardium: An incidental finding. 3053 79