Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0079731 (B-cell lymphoma)
 16,671 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Extranodal lymphoma occurs in ~40% of all patients with lymphoma and has been described in virtually all organs and tissue. However, diffuse large B-cell lymphoma (DLBCL), which is the most common histological subtype of non-Hodgkin's lymphoma (NHL), primarily arising in the retroperitoneal region has been rarely reported. Primary retroperitoneal lymphoma without renal or ureteral involvement affecting the genitourinary system has not been reported until now. In this article, we report the rare case of a young female suffering with primary DLBCL located simultaneously in the retroperitoneal and gastrointestinal region. The first sign of this disease was renal colic. Pathological assessment was performed using immunohistochemistry staining, revealing positivity for CD20 and Ki67. DLBCL was the final confirmed diagnosis. Obtaining a definitive histological diagnosis by surgery and using exactly chemotherapy played an essential role in the treatment of our patient. This case serves as a reminder to include the differential diagnosis of primary retroperitoneal NHL when a patient presents with a retroperitoneal mass and the first symptom is renal colic.
 ...
PMID:Non-Hodgkin's lymphoma with uncommon clinical manifestations: A case report. 2662 32

T-Cell Rich B-Cell Lymphoma (TCRBCL) is relatively a new entity, lately classified as a morphologic variant of Diffuse Large B-cell lymphomas (DLBCL). It consists (1-3) % of all B-cell lymphomas. The rate is far less when describing cases of primary splenic involvement with TCRBCL. Pathologically, TCRBCL is described as a limited number of scattered, large, atypical b-cells embedded in a background of abundant t-cells and frequently histiocytes. The similarity of this malignancy with other types makes it difficult to distinguish between them. Thus, it needs expertise in both clinical and pathological fields to make the right diagnosis.Here, we present a case of an adult male patient whose first presentation and previous medical history of renal colic misguided the initial diagnosis and suggested another colic episode as the underlying ailment. However, further physical, radiological and histopathological investigations uncovered the presence of primary TCRBCL within spleen with no involvement of other sites. Moreover, unusual pathologic finding of CD3 positivity was proved by immunohistochemistry.
 ...
PMID:T-Cell B-Rich Lymphoma Presenting as Renal Colic with Positivity of CD3. 3120 21