Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0079731 (B-cell lymphoma)
 16,671 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The non-Hodgkin's lymphomas (NHL) occurring in children are described on the basis of the Kiel classification. As a rule, the NHL in children are of high-grade malignancy. The morphologic and immunologic features of all types of high-grade malignant B-cell lymphoma are described. The most frequent type of B-NHL in children is B-lymphoblastic lymphoma, including Burkitt and non-Burkitt types. Centroblastic lymphoma, immunoblastic lymphoma and unclassified high-grade malignant NHL are less common in children. The difference between the morphologic term "unclassified" and the immunologic definition "non-B/non-T" or "null" (or "unclassified") is explained. The equivalents of the various lymphoma types in the Lukes-Collins and Rappaport classifications are given.
 ...
PMID:[B-cell lymphomas (non-Hodgkin's lymphomas of B type) in children--morphologic and immunologic spectrum]. 698 72

Centroblastic diffuse large B cell lymphoma (DLBCL) samples were analyzed by immunohistochemistry to evaluate the expression of p53, Bcl-2, Survivin, XIAP, and Ki-67. Survivin was the only protein which expression exhibited a trend for impact in progression-free (p = .077) and overall survival (p = .054). In the Mann-Whitney test, Survivin expression correlated with a negative overall survival (p = .045). These results appeared to be intimately related to Survivin cytoplasmic localization. Moreover, the anti-apoptotic proteins Bcl-2 and Survivin were less frequent in centroblastic DLBCL. Our results indicate that centroblastic DLBCL may be a disease with characteristic biology and clinical course and, therefore, specific prognostic factors.
 ...
PMID:Centroblastic diffuse large B cell lymphoma displays distinct expression pattern and prognostic role of apoptosis resistance related proteins. 2257 41