Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0079731 (B-cell lymphoma)
 16,671 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Anaplastic lymphoma kinase-positive large B-cell lymphoma (ALK+LBCL) is a rare non-Hodgkin lymphoma that exhibits a characteristic immunoblastic/plasmablastic morphology and is frequently expressing Clathrin-anaplastic lymphoma kinase fusion protein. Since being negative for T- and B- linage markers, this tumor is easy to be misdiagnosed, especially when it has unusual morphology and immunophenotype. Here, we report an ALK+LBCL with a diagnostic pitfall of carcinoma. The patient was a 28-year-old man with enlargement of a right submandibular lymph node. Morphologically, the lymph node had an unusual nodular growth pattern, with nodules surrounded by collagen bands. The neoplastic cells expressed epithelial membrane antigen, CD138, CD38, Mum-1, but negative for T- and B- linage markers, and showed a strong granular cytoplasmic Anaplastic Lymphoma Kinase staining pattern. Some tumor cells had the expressing of Cytokeratin.
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PMID:Anaplastic lymphoma kinase-positive large B-cell lymphoma with a diagnostic pitfall of carcinoma: a case report. 3196 73