Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0079731 (B-cell lymphoma)
 16,671 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We describe the clinical, histological, and immunohistochemical features of four cases of primary low-grade B-cell lymphoma of the liver. The lymphomas were first seen as a solitary nodule in two patients and as two nodules in the third patient. These were found incidentally in an otherwise normal liver during abdominal surgery for other causes. In the fourth patient, several up to 2 cm nodules of lymphoma were found in a liver removed before transplant for chronic active hepatitis and cirrhosis. There was no evidence of lymphoma elsewhere in any of the patients. One patient has remained well, without evidence of lymphoma, 1 year after resection, one died intraoperatively, one is lost to follow-up, and the transplanted patient died 1 year after transplant from complications without evidence of recurrent lymphoma. The histology was typical of low-grade B-cell lymphoma of mucosa-associated lymphoid tissue (MALT)-type with centrocyte-like cells surrounding reactive B-cell follicles and forming lymphoepithelial lesions with bile ducts. Primary hepatic lymphomas are rare, and most reported cases have been high-grade B-cell lesions. The liver should be added to the list of extranodal sites where low-grade MALT lymphoma may occur.
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PMID:Primary low-grade hepatic B-cell lymphoma of mucosa-associated lymphoid tissue (MALT)-type. 772 67

We report a case of primary hepatic non-Hodgkin's lymphoma in a 77-year-old man with chronic hepatitis C. Laboratory data revealed slightly elevated liver function parameters and positive antibody for hepatitis C virus (HCV). Abdominal ultrasonography showed a low-echogenic tumor, about 5 cm in diameter, in the left lateral segment. Abdominal computed tomography showed that the tumor was marginally enhanced in the early phase, but no enhancement was seen in the late phase. Magnetic resonance imaging showed that the tumor was hypointense in relation to the liver on T1-weighted images, but hyperintense on T2-weighted images. Hepatic angiography showed a homogeneously stained hypervascular tumor. Under the diagnosis of a liver tumor, thought to be a hepatocellular carcinoma, left lateral segmentectomy was performed. Histological examination confirmed a diagnosis of non-Hodgkin's diffuse large B-cell lymphoma that was positive for L-26 and CD79Alpha, but negative for CD3 and UCHL-1. The surrounding liver tissue showed signs of chronic active hepatitis. Multiple recurrent lesions were found in the liver, spleen, and iliac bones 4 months postoperatively. However, complete remission was achieved after five courses of systemic chemotherapy using pirarubicin, cyclophosphamide, vincristine sulfate, and prednisolone. The patient has been carefully followed up for about 1 year since his operation, and has been doing well. We review the literature on primary non-Hodgkin's lymphoma arising in the liver infected by HCV.
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PMID:Primary hepatic non-Hodgkin's lymphoma in a patient with chronic hepatitis C: report of a case. 1505 56

The coexistence of chronic active hepatitis C with cryoglobulinemia and B-cell lymphoma has been presented in numerous case reports. However, the combination of these conditions with T-cell lymphoma has never been described before. We present the case of a patient who suffered chronic active hepatitis C, cryoglobulinaemia and B-cell lymphoma and was later complicated by cutaneous T-cell lymphoma (CTCL).
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PMID:Coexistence of B-cell non-Hodgkin lymphoma and cutaneous T-cell lymphoma in a patient with chronic hepatitis C and cryoglobulinaemia. 1973 2

We describe a rare case of primary cutaneous marginal zone B-cell lymphoma (PCMZL) in a 33-year-old male affected by hepatitis B virus (HBV)-related chronic active hepatitis. The patient presented with multiple cutaneous papulonodular lesions characterized by polymorphic immunomorphology, with inverse pattern of immunoglobulin light chain restriction in two different lesions, coupled with mucin deposition and anetoderma in a third lesion. The involution of lesions of PCMZL with secondary anetoderma has been previously described, but this has not been reported in the context of multiple lesions showing differing immunoglobulin light chain restriction. We speculate that these findings may be secondary to a variable interaction between a chronic antigenic stimulus (i.e. HBV) and its specific immune response.
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PMID:Primary cutaneous marginal zone B-cell lymphoma with anetoderma: spontaneous involution plus de novo clonal expansion. 2121 95