Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0079731 (B-cell lymphoma)
 16,671 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Acute liver failure due to hepatic involvement by haematological malignancies is very rare, and usually has a rapidly fatal prognosis. We describe the case of a man who was treated for diffuse large B-cell lymphoma, and achieved a complete remission after eight courses of chemotherapy. He then presented with acute liver failure. Transjugular liver biopsy revealed massive infiltration by lymphomatous cells, with extensive necrosis. A CT scan did not show any evidence of extrahepatic lymphoma. The patient recovered from the liver failure following combined immuno-chemotherapy. Recurrence of the disease should be included in the differential diagnosis of patients with haematological malignancies and acute liver failure, even without evidence of extrahepatic involvement.
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PMID:Acute liver failure as the sole manifestation of relapsing non-Hodgkin's lymphoma. 1171 83

Acute liver failure is a rare but life-threatening illness with an incidence of 2-8 per million population. The most common causes of acute liver failure include drug ingestion and viral hepatitis followed by ischaemic hepatocellular injury and, less commonly, malignancy. Our patient presented with acute liver failure, which was found to be secondary to hepatic infiltration by diffuse large B-cell lymphoma. He received early treatment and has been in remission for more than a year after his initial presentation. To the best of our knowledge, our patient is the second reported survivor of acute liver failure caused by malignant hepatic infiltration by diffuse large B-cell lymphoma.
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PMID:Diffuse large B-cell lymphoma causing acute liver failure: a rare case of survival. 2596 90

Acute liver failure (ALF) is a relatively rare presentation of non-Hodgkin lymphoma, often found only during postmortem examination in patients. We treated a 33-year-old woman with prominent jaundice who was diagnosed with diffuse large B-cell lymphoma presenting as ALF. We could not perform liver biopsy during the critical phase because of coagulopathy, but gastric biopsy showed the infiltration of lymphoma cells. The patient was successfully treated with rituximab and chemotherapy and she survived. Malignant lymphoma should be considered in the differential diagnosis of patients who show liver dysfunction, and biopsy should be performed.
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PMID:Diffuse large B cell lymphoma primarily presenting as acute liver failure in a surviving patient. 3104 44

Acute liver failure (ALF) associated with malignant infiltration of the liver is rare and its pathological and radiologic features remain poorly described. An 87-year-old man was admitted to our hospital for anorexia for several days, high-grade fever from the previous day, and liver dysfunction but suddenly died on day 3 of hospitalization due to ventricular fibrillation. The patient was diagnosed at autopsy with malignant diffuse large B-cell lymphoma. To the best of our knowledge, this report represents a valuable addition to the ALF literature describing a case of ALF associated with diffuse large B-cell lymphoma diagnosed at autopsy.
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PMID:Acute liver failure associated with diffuse large B-cell lymphoma: an autopsy case report. 3191 74