Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0079731 (B-cell lymphoma)
 16,671 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Lyme borreliosis is a tick-borne zoonosis due to bacterial infection by Borrelia (B.) burgdorferi sensu lato The disease presents differently in Europe or North America and may be called European borreliosis when acquired in Europe. Lyme borreliosis evolves in 3 stages. The main manifestations include cutaneous, neurological, and joint involvement. Erythema migrans (EM) is the most specific and most frequent finding in patients with Lyme borreliosis. It is the hallmark of early-localized borreliosis. EM is a slowly expanding red macula that occurs in about 60-80% of patients contracting Lyme borreliosis. Central clearing of the red patch can occur. It appears at the site of the tick bite, 7 to 20 days after the bite. Borrelial lymphocytoma (BL) occur rarely in patients with the early-disseminated stage of the disease. BL is a red or brown nodule or plaque located on the nipple, the earlobe, the scrotum, or the face. It should not be confused with cutaneous B-cell lymphoma. Acrodermatitis chronica atrophicans (ACA) is the cutaneous manifestation of late borreliosis. It starts as a violaceous patch, usually located on the extensor surface of a limb. Periarticular nodules and cords can also be present. Without treatment, it will evolve over weeks or months to the typical atrophic stage with extensive dermo-epidermal atrophy and visibility of superficial veins. Only these 3 manifestations are clearly related to an infection with B. burgdorferi. The relationship between infection with B. burgdorferi and other dermatoses, especially morphea, lichen sclerosus, and interstitial granulomatous dermatitis is still debated.
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PMID:[Dermatological aspects of Lyme borreliosis]. 1739 84

Histological lesions due to Lyme Borreliosis are not specific and are generally characterized by a lymphocytic and plasma cell infiltrate around blood vessels. Nevertheless, the presence of plasmocytes in cutaneous annular lesions will suggest a diagnosis of Erythema migrans. The presence of tick mouthparts in an insect bite lesion is also evocative of a tick bite. If the diagnosis of lymphocytoma cutis is based on histology, only pathological clinical and biological findings will rule out a Centro follicular cutaneous B cell lymphoma. Plasma cells and ectatic vessels of cutaneous sclerous lesions may suggest acrodermatitis chronica atrophicans. Articular lesions are characterized by non-specific hypertrophic synovitis and peripheral nervous lesions by axonal neuropathy. Moreover, in situ characterization of spirochetes by silver stains or immunohistochemistry is not available in routine.
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PMID:[Histopathology of lyme borreliosis]. 1799 49