Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0043352 (
xerostomia
)
4,250
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Coordination of intracellular Ca
2+
signaling in parotid acini is crucial for controlling the secretion of primary saliva. Previous work from our lab has demonstrated acidic-organelle Ca
2+
release as a participant in agonist-evoked signaling dynamics of the parotid acinar cell. Furthermore, results implicated a potential role for the potent Ca
2+
releasing second messenger
NAADP
in these events. The current study interrogated a direct role of
NAADP
for Ca
2+
signaling in the parotid salivary gland acinar cell. Use of live-cell Ca
2+
imaging, patch-clamp methods, and confocal microscopy revealed for the first time
NAADP
can evoke or enhance Ca
2+
dynamics in parotid acini. These results were compared with pancreatic acini, a morphologically similar cell type previously shown to display
NAADP
-dependent Ca
2+
signals. Findings presented here may be relevant in establishing new therapeutic targets for those suffering from
xerostomia
produced by hypofunctioning salivary glands.
...
PMID:Role of NAADP for calcium signaling in the salivary gland. 3094 88
