Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0043352 (xerostomia)
 4,250 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Mycotic stomatitis is one of the most frequent oral complications in cancer patients, but the effects of drug therapy for the disease are unknown. A prospective study was conducted to determine the effects of drug therapy for mycotic stomatitis in hospitalized patients, including cancer patients. ITCZ-OS and MCZ-GEL were used as antifungal agents. Atotal of 104 hospitalized patients were the study subjects for whom the Department of Dentistry was requested to provide dental treatment or oral care by other departments between March and May 20XX. Mycotic stomatitis was seen in 29%(n=30)of the subjects. Among subjects with mycotic stomatitis, 60%(n=18)had cancer, 57%(n=17)received steroids for two weeks or less, 57%(n=17)showed a performance status of 3 or 4, 70%(n=21)had mild to more severe xerostomia, and 53%(n=16)had an unclean oral cavity. As a result of drug therapy, the clinical symptom scores for white coat and flare and the total score were significantly improved on days 3 and 7 compared with before treatment, and the overall improvement rate was 83% on day 3 and 88% on day 7. Many patients hospitalized with mycotic stomatitis have cancer, and it was suggested that drug therapy is effective for them.
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PMID:[Effectiveness of antifungal agents for oral candidiasis in inpatients]. 2290 48

Oropharyngeal candidiasis is one of the common manifestations seen in cancer patients on cytotoxic therapy and invasion into deeper tissues can occur if not treated promptly. Emergence of antifungal drug resistance is of serious concern owing to the associated morbidity and mortality. The present study aims at evaluation of clinicomycological association and antifungal drug susceptibility among the 180 recruited patients with cancer on chemotherapy and/or radiotherapy with signs or symptoms suggestive of oral candidiasis. Speciation and antifungal susceptibility was done by Microbroth dilution method for fluconazole, Itraconazole, and Amphotericin B as per standard microbiological techniques. Chi-square test was used for statistical analysis (p < 0.05 was considered statistically significant). Candida albicans was the predominant species isolated (94) (58%) followed by Candida tropicalis (34) (20.9%). Fluconazole and Itraconazole showed an overall resistance rate of 14% and 14.8%, respectively. All the isolates were susceptible to Amphotericin B. There was a significant association between the presence of dry mouth and isolation of Candida (p < 0.001). Such clinicomicrobiological associations can help in associating certain symptoms with the isolation of Candida. Species level identification with in vitro antifungal susceptibility pattern is essential to choose the appropriate drug and to predict the outcome of therapy.
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PMID:Oral Candidiasis among Cancer Patients Attending a Tertiary Care Hospital in Chennai, South India: An Evaluation of Clinicomycological Association and Antifungal Susceptibility Pattern. 2740 71