Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0043352 (xerostomia)
 4,250 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

PTSD is a chronic mental illness that may arise after an individual experiences or witnesses a life-threatening event. Symptoms consist of persistent reexperiencing of the event, avoidance of reminders of the event, a numbing of positive emotions, and social withdrawal. A depressed mood and excessive use of alcohol and tobacco may accompany the disorder. PTSD afflicts approximately 5% of men and 11% of women. Dental disease may be extensive because of neglect of oral hygiene compounded by cigarette smoking. Dental treatment includes preventive education, oral cancer screening, and prescribing saliva substitutes or stimulants and anticaries agents to combat medication-induced xerostomia. Precautions must be taken when prescribing or administering certain analgesics, antibiotics, or sedative agents that may adversely interact with the psychiatric medications or when performing surgery because of the long-term effects of alcohol abuse.
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PMID:Posttraumatic stress disorder: psychopathology, medical management, and dental implications. 1471 50

When venlafaxine was introduced in 1994, it was the first of the newer generation antidepressants to be classified as a serotonin norepinephrine reuptake inhibitor (SNRI). An extended release (XR) formulation of venlafaxine, introduced in 1997, subsequently received regulatory approval for treatment of three anxiety disorders: generalized anxiety disorder, social anxiety disorder and panic disorder. Although less extensively studied, venlafaxine XR also appears to have efficacy for two other anxiety disorders, post-traumatic stress disorder and obsessive-compulsive disorder. In contrast to the treatment of depression, for which meta-analyses suggest an efficacy advantage relative to selective serotonin reuptake inhibitors (SSRIs), evidence of differential efficacy has not yet been established for any of the anxiety disorders. The overall tolerability profile of venlafaxine XR is generally comparable to that of the SSRIs, although there is greater incidence of noradrenergically mediated side effects (i.e., dry mouth and constipation), as well as a dose-dependent risk of treatment-emergent high blood pressure. Concerns about safety in overdose have also recently emerged. Despite these caveats, venlafaxine XR is an effective and generally well-tolerated option for treatment of anxiety disorders.
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PMID:Treatment of anxiety disorders with venlafaxine XR. 1653 31

The aim of this study was to assess the oral health condition of Croatian war veterans with post-traumatic stress disorder (PTSD). The study included 50 men who experienced combat stress and had been diagnosed with PTSD. They were compared with the group of 50 age-matched men who did not participate in war and did not have PTSD. Xerostomia, oral mucosal lesion, oral hygiene status, dental, and periodontal conditions, as well as temporomandibular disorders (TMDs) were assessed and compared between the groups. Subjects in PTSD group had poorer oral hygiene, and periodontal status compared with the control subjects. Furthermore, they had less teeth than the control group (P = 0.04). Although, there was no statistically significant difference between the groups in Decayed, Missing and Filled Teeth (DMFT) index (P = 0.36), PTSD group had more decayed and missing teeth, but less filled teeth (P < 0.05 for all). According the Research Diagnosis Criteria for Temporomandibular Disorder (RDC/TMD), PTSD patients had more TMD diagnoses compared with the control subjects. The most prevalent diagnosis was myofascial pain (48%) in PTSD group, while in the control group it was disc displacement with reduction (8%). It can be concluded that the oral health condition in PTSD patients is significantly affected compared with the control subjects.
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PMID:Oral health status in war veterans with post-traumatic stress disorder. 1720 72