Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0043352 (
xerostomia
)
4,250
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Oral drug therapy in patients with
short bowel syndrome
can be quite challenging. We report the case of a 40-yr-old woman with
short bowel syndrome
and depression requiring antidepressant drug therapy. After buccal administration of amitriptyline, therapeutic serum antidepressant concentrations were attained despite the patient having only 18 inches of proximal small bowel. Clinical improvement in mood was seen, with the only drug side effects being
dry mouth
and bitter drug taste. Buccal absorption likely is playing a major role in attaining therapeutic serum tricyclic antidepressants drug concentrations.
...
PMID:Amitriptyline absorption in a patient with short bowel syndrome. 1044 71
