Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0043346 (xeroderma pigmentosum)
 2,924 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
XPA 232
Mol 223
XPD 200
Sep 190
p53 179
trichothiodystrophy 178
XPC 168
endonuclease 131
XPG 128
TFIIH 115
helicase 100
XPB 95
XPF 88
ERCC1 79
DNA polymerase 67
RNA polymerase II 59
DDB2 51
ERCC2 51
XPV 50
Bloom syndrome 49
DNA helicase 49
A-T 45
DNA polymerase eta 44
ATP 42
proliferating cell nuclear antigen 40
ubiquitin 38
DDB1 37
NER 35
CSB 34
xeroderma pigmentosum variant 33
cancer susceptibility 32
ERCC3 30
DNA-binding protein 28
polypeptide 28
POLH 26
transcription factor TFIIH 26
pol 26
She 24
catalase 24
Werner syndrome 24
photolyase 23
DNA binding protein 23
XPE 23
p48 22
proteasome 21
ATPase 21
ERCC5 21
Pol 20
p21 20
ERCC4 20
RPA 19
CSA 19
lymphoid 19
hypoxanthine-guanine phosphoribosyltransferase 18
fused 18
DNA repair protein 18
ras 18
p44 15
DNA repair enzyme 15
tRNA 15
FHOD1 15
HR23B 15
ATM 14
ubiquitin ligase 14
p62 14
ATR 14
dihydrofolate reductase 14
DNA-binding domain 14
tumour suppressor 13
C protein 13
H2AX 13
NMR 13
thymus 12
interferon 12
patched 12
axonal 12
histone 12
centrin 12
Li-Fraumeni syndrome 11
c-myc 11
MRI 11
MF1 11
zinc finger 11
CAT 11
neurofibromatosis 10
deoxyribonuclease 10
general transcription factor 10
XRCC1 10
collagen 10
excision repair cross-complementing 1 9
WRN 9
OGG1 9
hairless 9
ADP 9
hHR23B 9
DNA polymerase alpha 8
CAK 8
XRCC3 8
E3 ubiquitin ligase 8
HPRT 8
poly(ADP-ribose) polymerase 8
CPD 8
SDS 8
PARP-1 8
BRCA1 8
telomeric 8
superoxide dismutase 7
insulin 7
metallothionein 7
nuclear protein 7
glutathione S-transferase 7
DNA polymerase delta 7
PARP 7
hOGG1 7
ataxia telangiectasia mutated 7
cullin 4A 7
Chk1 7
mer 7
BTF2 7
RAD23B 7
ROS 6
proto-oncogene 6
X-linked 6
N-ras 6
E2F1 6
p34 6
CDKN2A 6
p16 6
NAD 6
epidermal growth factor 6
DNA gyrase 6
PHA 6
endonuclease III 6
cullin 6
thymidine kinase 6
p52 6
single-stranded DNA binding protein 6
hedgehog 6
RAD26 6
glutathione peroxidase 5
DNA ligase 5
RRM1 5
HD2 5
MAPK 5
cage 5
TPA 5
methylguanine-DNA methyltransferase 5
p16INK4a 5
INK4a 5
adenosine deaminase 5
Dictyostelium 5
excision repair protein 5
epidermal growth factor receptor 5
caspase-3 5
SIRT1 5
DDP 5
ara 5
ABL 5
Bcl-2 5
melanocortin 1 receptor 5
more...
Disease
xeroderma pigmentosum 2924
cancer 774
skin cancer 444
Cockayne syndrome 440
carcinogenesis 271
tumor 262
XPD 244
trichothiodystrophy 220
XPG 161
ATM 152
melanoma 147
squamous cell carcinoma 117
XPF 111
XPB 109
XP-A 104
photosensitivity 101
BLM 99
basal cell carcinoma 83
Fanconi syndrome 67
anemia 67
Fanconi 64
genetic disorder 49
tumorigenesis 46
carcinoma 45
WRN 43
premature aging 43
breast cancer 39
lung cancer 38
mole 37
nevoid basal cell carcinoma syndrome 36
CSB 34
CSB 34
brittle hair 33
progeria 31
XPV 31
keratosis 29
ichthyosis 27
ichthyosis 26
herpes simplex 26
RTS 26
mental retardation 24
dysplastic nevi 24
skin disease 24
mental retardation 23
XPE 23
conjunctiva 22
Epstein 21
CSA 20
Down syndrome 20
cornea 19
bladder cancer 19
colorectal cancer 18
neurological disease 18
metastases 18
freckles 18
mole 17
retinoblastoma 16
leukemia 16
Alzheimer's disease 15
adenocarcinoma 15
skin tumor 14
non-small cell lung cancer 14
nonmelanoma skin cancer 14
dyskeratosis congenita 13
colon cancer 13
psoriasis 13
deafness 13
cutaneous melanoma 13
Huntington's disease 13
plaque 12
Li-Fraumeni syndrome 12
epidermolysis bullosa 11
hepatocellular carcinoma 11
epidermodysplasia verruciformis 11
gastric cancer 11
poikiloderma 10
neurofibromatosis 10
brain atrophy 10
peripheral neuropathy 10
Melanoma 10
lentigo 9
lupus 9
epithelioma 9
angiosarcoma 9
tuberous sclerosis 9
neoplastic transformation 8
ovarian cancer 8
glioma 8
NBS 8
immune deficiency 8
developmental delay 8
head and neck cancer 8
immunodeficiency 8
lymphoma 8
SDS 8
Parkinson's disease 7
herpes 7
porokeratosis 7
chemical carcinogenesis 7
amyotrophic lateral sclerosis 7
urticaria 7
keratoacanthoma 7
West 7
prostate cancer 7
cytomegalovirus 7
tumor progression 7
systemic lupus erythematosus 7
rare disease 6
PHA 6
pellagra 6
familial adenomatous polyposis 6
squamous cell carcinoma of the skin 6
vaccinia 6
polyposis 6
osteoporosis 6
diabetes 6
Gardner's syndrome 6
depression 6
sensorineural hearing loss 6
HIV 6
telangiectasia 6
WT1 5
acne 5
virus infection 5
Lesch-Nyhan syndrome 5
porphyria 5
cold 5
trisomy 5
GSH 5
FANCJ 5
Syndrome 5
DDP 5
dermatitis 5
atopic dermatitis 5
chronic myeloid leukemia 5
neuropathy 5
sarcoma 5
cataract 5
ABL 5
developmental disabilities 5
xerosis 5
hepatitis B 5
lichen planus 4
diphtheria 4
lung carcinoma 4
Infection 4
keratosis 4
retinopathy 4
infectious diseases 4
renal failure 4
dementia 4
melanosis 4
pancreatic cancer 4
cheilitis 4
chronic lymphocytic leukemia 4
cognitive impairment 4
ventricular dilatation 4
human papilloma virus 4
Lynch syndrome 4
human papilloma virus 4
more...
Symptom
erythema 43
ataxia 27
photophobia 12
skin damage 9
anesthesia 7
spasticity 6
cachexia 6
collapse 5
cerebellar ataxia 5
dystonia 5
weakness 4
stridor 4
chorea 4
dysarthria 4
pain 3
ophthalmoplegia 2
starvation 2
vomiting 2
hypotonia 2
seizures 2
tremor 2
scaly skin 2
blepharospasm 1
paresis 1
Ill 1
ENT 1
stigma 1
Decreased activity 1
exhaustion 1
fatigue 1
nausea and vomiting 1
sleepiness 1
Cri du chat 1
Inspiratory stridor 1
prominent nose 1
hidroa 1
analgesia 1
nausea 1
muscle cramps 1
abnormal gait 1
dyspnea 1
myoclonus 1
athetosis 1
Drug
Dermatol 283
caffeine 51
Mutagen 19
-deoxyadenosine 12
Asn 11
G418 10
lysine 6
ROS 6
BLM 5
Gel 3
ZnCl2 3
Oxaliplatin 3
Retinoic acid 3
ZnCl2 3
DNase I 3
nitroglycerin 3
ABC 2
Acitretin 2
Hypaque 2
ascorbate 2
Monit 2
Arsenic trioxide 2
GEO 2
AGG 2
Bortezomib 2
TAT 2
Neocarzinostatin 2
Hypaque 2
THF 2
Etoposide 2
Imiquimod 2
Anthramycin 1
MRC 1
Gemzar 1
Tannic acid 1
MDS 1
Adriamycin 1
Pyridoxamine phosphate 1
Ara-A 1
NH3 1
Amifostine 1
Tarceva 1
TEL 1
vitamin E 1
Indomethacin 1
Vitamin B 1
niacin 1
Trabectedin 1
TAC 1
Photofrin II 1
ENT 1
ALA 1
ampicillin 1
pyridoxal phosphate 1
CSF 1
Herceptin 1
Isotretinoin 1
IFN-beta 1
PTC 1
Serum albumin 1
Vitamin A 1
AraC 1
Erlotinib 1
Dithranol 1
ADR 1
Fludarabine 1
Enzyme
endonuclease 131
DNA polymerase 79
RNA polymerase 65
catalase 35
deoxyribonuclease 32
PRE 30
chloramphenicol acetyltransferase 23
ATPase 22
proteasome 22
DNA ligase 20
hypoxanthine-guanine phosphoribosyltransferase 20
DNA ligase 20
topoisomerase 18
DNase 18
ERK 15
topoisomerase 14
dihydrofolate reductase 14
luciferase 13
protein kinase 12
PARP 12
cdc2 12
beta-galactosidase 11
PAT 11
glutathione S-transferase 9
endonuclease V 9
APC 8
mitogen-activated protein kinase 8
AP lyase 8
micrococcal nuclease 7
superoxide dismutase 7
focal adhesion kinase 7
RNase 6
S1 nuclease 6
calcineurin 6
thymidine kinase 6
RNase 6
glutathione peroxidase 5
adenosine deaminase 5
adenosine deaminase 5
NQO1 4
caspase-3 4
Fpg protein 4
collagenase 4
reverse transcriptase 4
histone acetyltransferase 4
MEK 3
ribonuclease 3
alkaline phosphatase 3
ornithine decarboxylase 3
ribonucleotide reductase 3
ribonucleotide reductase 3
ribonuclease 3
NADPH oxidase 2
protein phosphatase 2A 2
TAT 2
proteinase K 2
phosphodiesterase 2
PDE 2
complex I 2
adenine phosphoribosyltransferase 2
TdT 2
methylenetetrahydrofolate reductase 2
thioredoxin reductase 2
lactate dehydrogenase 2
NADPH oxidase 2
interstitial collagenase 2
ACS 2
methylenetetrahydrofolate reductase 2
aldehyde dehydrogenase 1
polynucleotide kinase 1
SPT 1
ADPase 1
glyceraldehyde-3-phosphate dehydrogenase 1
glyceraldehyde-3-phosphate dehydrogenase 1
dihydropyrimidine dehydrogenase 1
glucose-6-phosphate dehydrogenase 1
factor D 1
cytochrome oxidase 1
phosphoglycerate kinase 1
lysozyme 1
caspase-1 1
MAT 1
ATP synthase 1
urokinase-type plasminogen activator 1
NO synthase 1
ATase 1
factor C 1
MAT 1
glyceraldehyde-3-phosphate dehydrogenase 1
MMP 1
ubiquitin-protein ligase 1
SPT 1
tyrosinase 1
endodeoxyribonuclease 1
IKK 1
TGT 1
sulfatase 1
phosphatidylinositol 3-kinase 1
glyceraldehyde-3-phosphate dehydrogenase 1
CPT 1
CGT 1
peroxiredoxin 1
peroxidase 1
deoxyribonuclease 1
PNGase F 1
arylsulfatase A 1
glutathione reductase 1
RNase H 1
phosphoinositide 3-kinase 1
dopamine beta-hydroxylase 1
CPT 1
MIP 1
glyceraldehyde-3-phosphate dehydrogenase 1
argininosuccinate synthetase 1
urease 1
MEKK1 1
endonuclease VII 1
transcriptase 1
AMP-activated protein kinase 1
succinate dehydrogenase 1
3'-exonuclease 1
trypsin 1
tyrosine hydroxylase 1
CPT 1
thymidylate synthase 1
apyrase 1
transaldolase 1
dihydropyrimidine dehydrogenase 1
Compound
DNA 2183
pyrimidine 300
pyrimidine 299
XPA 195
XPA 195
Dec 170
Clin 64
oxygen 54
caffeine 51
pyrene 51
ATP 42
lysine 38
zinc 29
arginine 28
His 26
methyl methanesulfonate 24
hydrogen 20
DDP 18
anthracene 16
H2O2 15
calcium 15
phosphate 15
retinoic acid 14
alanine 14
ADP-ribose 13
Asp 13
sodium 13
iron 12
EMS 12
acetate 12
nitrogen 12
PAT 11
CAT 11
cysteine 11
ADP 11
CAT 11
CAT 11
BLM 10
AAF 10
ADP 9
tyrosine 9
ADP 9
water 9
PEG 9
serine 9
salt 9
MMC 8
vitamin D 8
glycerol 8
SDS 8
tryptophan 8
methionine 7
nickel 7
aflatoxin B1 7
MTT 7
N-acetylcysteine 7
uridine 7
NAD 6
Psoralen 6
NAD 6
urea 6
Arsenic 6
bromide 6
3-aminobenzamide 5
GSH 5
DBA 5
TTS 5
Pac 5
tryptophan 5
Phe 5
TPA 5
tryptophan 5
formaldehyde 5
GSH 5
A 1 5
TPA 5
methane 5
copper 5
TTP 5
Novobiocin 5
dUTP 5
tryptophan 5
ABL 5
formaldehyde 5
cAMP 5
SCC 4
BUdR 4
BCR 4
Neuronal 4
Benzo[a]pyrene 4
MOP 4
MNNG 4
aldehyde 4
Aphidicolin 4
Aphidicolin 4
ammonium 4
cadmium 4
DAMP 4
leucine 4
NH2 4
DEAE 4
methanol 4
dATP 4
sulfate 4
Acrolein 3
Cyclosporine 3
Hydroxyurea 3
glutamate 3
pyridine 3
VP-16 3
MMA 3
NADPH 3
MMA 3
GTP 3
potassium 3
nitric oxide 3
glutamine 3
Cycloheximide 3
8-OHdG 3
glutamic acid 3
silver 3
cobalt 3
ethanol 3
glucose 3
NADPH 3
aldehyde 3
NOP 3
dUMP 3
MMA 3
SPF 3
TMP 2
threonine 2
diacetate 2
aspartic acid 2
FAP 2
acridine 2
Cu(II) 2
PEG 2
TCA 2
ACS 2
dCMP 2
Bantu 2
Estrogen 2
CCC 2
GSSG 2
ENU 2
m-AMSA 2
DMA 2
creatinine 2
H2S 2
ACS 2
phosphonoacetic acid 2
AMP 2
FAP 2
proline 2
Gly 2
CCC 2
Hypaque 2
acrylamide 2
acetaldehyde 2
more...