Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0043346 (
xeroderma pigmentosum
)
2,924
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In mammalian cells, 72-kD heat shock protein (
HSP72
) is the major stress-inducible protein that is thought to play a protective role against the various environmental stresses. In order to know the induction mechanism of
HSP72
, we examined the
HSP72
in DNA repair-deficient
xeroderma pigmentosum
group A fibroblasts (XP2OSSV) and normal fibroblasts (WI38VA13) by the indirect immunofluorescence method using a monoclonal antibody specific for the inducible 72-kD protein. Heat-shock treatment of the same survival fraction (5% survival) induced
HSP72
in
xeroderma pigmentosum
(XP) and normal cells. However, as compared with XP cells, normal cells showed the induction of
HSP72
more rapidly and strongly. When XP and normal cells were irradiated with UVC at the same survival dose (10% survival), apparent induction of
HSP72
was observed in both cell lines. In the case of UVC irradiation at the same dose (1.0 J/m2), though XP cells showed the induction of
HSP72
,
HSP72
was not induced in normal cells. In both cell lines, heat-shock treatment caused more rapid induction of
HSP72
than UV irradiation. These results suggest that the induction mechanism of
HSP72
might be different between heat-shock treatment and UV irradiation. In addition, in the case of UV irradiation, the extent of DNA damage after DNA repair or the cell death might be involved in the induction of
HSP72
.
...
PMID:Induction of the 72-kD heat shock protein in xeroderma pigmentosum complementation group A fibroblasts. 143 Dec 27
