Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0043167 (pertussis)
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Human Gene/Protein
Galanin receptor 1 10.7
Guanine nucleotide-binding regulatory protein 10.1
Type II adenylyl cyclase 9.7
JTV1 9.7
EP3-V 9.7
cone transducin alpha subunit 9.7
EP3-VI 9.7
melatonin receptor Mel1a 9.7
ERI3 9.7
Chemokine receptor-like 1 9.7
FRP3 9.7
hyperpolarization activated cyclic nucleotide-gated potassium channel 2 9.7
Galphaz 9.6
rhomboid domain containing 1 9.3
guanine nucleotide regulatory protein 9.1
PSP24 9.1
IL8R2 9.1
ANKRD13C 9.1
RGS19 protein 9.1
adenylate cyclase-inhibiting 9.1
Receptor activity-modifying protein 2 9.1
CRAM-A 9.1
GLPE 9.1
EDG-2 9.0
EDG-4 9.0
guanine nucleotide-binding regulatory protein 9.0
G protein-linked receptor 8.8
SNSR4 8.7
GPR20 8.7
pancreatic polypeptide receptor 8.7
P2Y14 8.6
AGS4 8.5
S1P5 8.5
guanine nucleotide-binding protein 8.5
G alpha q 8.5
adenylyl cyclase type V 8.4
Galpha14 8.4
DPT 8.4
GTP-binding protein 8.4
Gq class 8.4
protein kinase C, alpha 8.3
SCM-1beta 8.3
THBS1 protein 8.3
Head activator 8.3
Tog 8.3
AIF4 8.2
EP3A 8.2
nucleotide-binding protein 8.2
GTP binding protein 8.1
PI-TPbeta 8.1
alpha 2C adrenergic receptor 8.1
DSCR6 8.1
CC chemokine receptor 8 8.1
TG1019 8.1
IL1RL2 8.1
GPR63 8.1
NEM2 8.1
FLJ00018 8.1
CCL11 protein 8.1
guanine nucleotide binding protein 8.0
m3 muscarinic acetylcholine receptor 8.0
HCA1 8.0
transducin alpha 7.9
putative GTP-binding protein 7.9
beta-adrenergic receptor kinase 7.9
EDG2 7.9
Galphai2 protein 7.9
Prepronociceptin 7.9
Adenosine A3 receptor 7.9
protein kinase C, epsilon 7.9
myosin regulatory light chain interacting protein 7.9
Chemokine receptor CCR5 7.9
Rap1GAPII 7.9
Phosducin-like protein 7.9
LPA2 7.8
FPR1 7.7
putative G-protein 7.7
src-like kinase 7.7
P2Y14 receptor 7.7
LPA3 7.7
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Disease
pertussis 10.7
Reactive mastocytosis 10.7
Bordetella 10.2
Bordetella infection 10.1
Acute ischaemic heart disease 9.7
Purulent bronchitis 9.1
diphtheria 8.9
IPV 8.5
AGS4 8.5
nonfilarial elephantiasis 8.3
tetanus 8.1
FHA 8.1
NEM2 8.1
HCA1 8.0
Acute cough 7.7
localized skin infection 7.5
polio 7.4
AGS3 7.2
mumps 7.2
Chlamydia psittaci pneumonia 7.1
Other infectious diseases 7.1
Leiner's disease 7.0
cholera 6.9
Haemophilus meningitis 6.9
scarlet fever 6.8
rubella 6.8
Peritoneal infection 6.8
measles 6.7
cross-dependence 6.6
pseudocroup 6.5
allergic arthritis 6.4
lymphocytosis 6.4
Recurrent respiratory tract infections 6.3
Salmonella enteritis 6.3
NIID 6.1
Neutrophil dysfunction 6.1
Haemophilus 6.1
Gianotti-Crosti syndrome 6.1
viral leukemogenesis 6.0
Campylobacter enteritis 6.0
Haemophilus influenzae pneumonia 6.0
LAD2 5.9
posthitis 5.9
acute tonsillitis 5.9
acute pharyngitis 5.8
Mycoplasma pneumoniae pneumonia 5.8
INFECTION 5.7
laryngostenosis 5.7
Acute myocardial ischemia 5.6
Olfactory nerve 5.6
Acute respiratory infections 5.5
Acute Q fever 5.5
Infection induced 5.5
GH-secreting pituitary adenoma 5.5
Congenital nephrotic syndrome 5.5
Lowe 5.5
Retinal vasculitis 5.4
AD6 5.4
respiratory infection 5.4
varicella 5.4
NSIP 5.3
Lennox syndrome 5.3
Haemophilus infections 5.3
Haemophilus influenzae meningitis 5.1
myofasciitis 5.1
vasitis 5.1
sinobronchial syndrome 5.1
RGS 5.1
smallpox 5.0
Young's syndrome 5.0
nursing caries 5.0
cough variant asthma 5.0
Coronavirus infection 4.9
EPI 4.9
inflamed eye 4.9
herpangina 4.9
Subclinical infection 4.9
congenital rubella 4.8
acute laryngitis 4.8
Stress cardiomyopathy 4.8
more...
Symptom
Purulent nasal discharge 8.1
Local swelling 8.0
sinus pain 7.3
Moderate pain 6.6
Injection site pain 6.3
persistent cough 6.2
impaired motor coordination 5.7
rundown 5.2
cough 4.8
Grimace 4.6
chronic cough 4.2
nocturnal cough 3.8
cyanosis 3.6
non-productive cough 3.5
generalized rash 3.5
Severe pain 3.4
precordial pain 3.2
incoordination 3.2
peri-menopausal 3.2
catarrh 3.1
labored breathing 2.9
productive cough 2.9
Respiratory symptoms 2.8
Catch 2.7
postnasal drip 2.7
sneezing 2.6
ataxic gait 2.6
Fluctuation 2.4
prostration 2.1
Tenderness 2.1
vomiting 2.1
neurological disability 1.8
bitter taste 1.8
erythema 1.8
wheezing 1.8
hoarseness 1.7
pallor 1.7
arm pain 1.7
twitching 1.7
analgesia 1.6
sore throat 1.6
sleepiness 1.5
stridor 1.5
decreased appetite 1.5
pleuritic chest pain 1.5
tachypnea 1.4
rales 1.3
nasal discharge 1.3
respiratory distress 1.2
Neuropathic pain 1.2
seizures 1.1
rhinorrhea 1.1
anorexia 1.1
diarrhea 1.1
rigors 1.0
starvation 1.0
general problem 0.9
cerebellar ataxia 0.8
flushing 0.8
acute stress 0.8
collapse 0.8
Stiffness 0.7
HSA 0.7
hypothermia 0.7
muscle rigidity 0.6
tense 0.6
catatonia 0.6
abnormal gait 0.5
exertional dyspnea 0.5
syncope 0.5
hemoptysis 0.4
splenomegaly 0.4
paraparesis 0.2
pain 0.2
hypotonia 0.1
skin damage 0.1
polyuria 0.1
sciatica 0.1
hypercapnia 0.0
tremor -0.0
more...
Drug
Pertussis vaccine 10.3
Xaliproden 9.1
Sulfisomidine 9.1
Adsorbed tetanus toxoid 8.3
Guanadrel 8.1
Diphtheria toxoid 7.4
CFTM-PI 7.3
Tetanus toxoid 7.0
Rokitamycin 7.0
Japanese encephalitis vaccine 6.9
Diphtheria antitoxin 6.9
Dexamethasone acetate 6.6
Smallpox vaccine 6.3
Cefuzonam 6.3
Sulprostone 6.3
Forskolin 6.2
Iodophenyl 6.1
Deferoxamine mesylate 6.1
CPDX-PR 6.0
Fluspirilene 6.0
OMP 5.9
Enprostil 5.7
Manganese chloride 5.7
Butaprost 5.7
Spiegel 5.6
Minipress 5.6
Tiopronin 5.6
Cefpiramide 5.5
Alphagan 5.5
Denopamine 5.5
CZX 5.5
CZON 5.4
Cefprozil 5.4
Arlacel 5.4
Stelazine 5.3
CMNX 5.3
Olomoucine 5.2
MgSO4 5.1
Platelet Activating Factor 5.1
Loracarbef 5.1
Penfluridol 5.0
Ancrod 5.0
EPI 5.0
Engerix-B 4.9
MZM 4.9
ETA 4.8
Zaditen 4.8
Tropicamide 4.8
Clonidine 4.8
OFLX 4.7
Angiotensin II 4.7
BCG vaccine 4.7
MEPM 4.7
Trifluoperazine 4.7
Maalox 4.6
CTRX 4.6
Cefditoren 4.6
Histamine 4.6
Gamma globulin 4.6
AC2 4.6
CEX 4.6
KAN 4.5
ICI 4.5
Atosiban 4.5
Ramelteon 4.3
Ceftibuten 4.3
Iloprost 4.2
Batimastat 4.1
Batimastat 4.1
Fenoldopam 4.1
9-THC 4.1
GRF 4.1
Imuran 4.0
Gallamine 3.9
Rolipram 3.9
Rimonabant 3.9
ACT 3.8
TPV 3.8
Poudre 3.8
Dipyrone 3.8
more...
Enzyme
ADP-ribosyltransferase 7.5
cytidylate cyclase 7.5
ADP-ribosyltransferase 7.5
adenylate cyclase 7.2
actinase E 7.2
phospholipase C 6.9
NAD glycohydrolase 6.9
EC 5.3.99.2 6.6
ADP-ribosylarginine hydrolase 6.4
PI-PLC 6.4
sphingosine kinase 6.4
GMT 6.2
UDP-N-acetylglucosamine acyltransferase 6.1
duodenase 6.0
phospholipase D 6.0
8-lipoxygenase 5.9
protein acyltransferase 5.8
GRK2 5.8
protein kinase C 5.7
cGMP phosphodiesterase 5.3
PAF acetyltransferase 5.3
cholesterol 25-hydroxylase 5.2
pyroglutamyl peptidase II 5.1
phospholipase A2 5.0
PTPase 5.0
PGE2 isomerase 5.0
ceramide kinase 4.9
GMP reductase 4.9
lysophospholipase D 4.9
phosphatidylinositol 3-kinase 4.9
phosphoinositide 5-phosphatase 4.8
phosphoinositide 3-kinase 4.8
dolichol kinase 4.7
diacylglycerol kinase 4.7
GRK5 4.7
serralysin 4.5
galactosyltransferase I 4.5
endo-alpha-N-acetylgalactosaminidase 4.5
Ins(1,4,5)P3 3-kinase 4.5
MEK 4.4
ancrod 4.4
PAF acetyltransferase 4.4
inositol 3-kinase 4.4
phosphodiesterase 4.3
ceramidase 4.3
KAR 4.3
VIP1 4.3
matrix metalloproteinase 14 4.2
guanylate cyclase 4.2
PKG 4.1
protein kinase 4.1
mitogen-activated protein kinase 4.1
phosphatidylinositol phospholipase C 4.1
quinolinic acid phosphoribosyltransferase 4.0
adenosine deaminase 4.0
adenosine deaminase 3.9
beta-1,4-galactosyltransferase 3.9
PARP 3.8
triphosphatase 3.8
apyrase 3.8
glutamate racemase 3.7
LTC4 synthase 3.7
IgA protease 3.7
p-nitrophenylphosphatase 3.7
thrombin 3.7
oligopeptidase B 3.7
lipoxygenase 3.7
HtrA 3.6
CaMKII 3.5
12-lipoxygenase 3.5
macrophage elastase 3.5
MIP 3.5
AMPK 3.5
MAP 3.5
NADPH oxidase 3.4
arachidonate 5-lipoxygenase 3.4
myosin light chain kinase 3.4
ATP diphosphohydrolase 3.4
venom phosphodiesterase 3.4
aequorin 3.3
more...
Compound
17-hydroxyyohimban-16-carboxylic acid 10.7
DTP 9.3
LTB4-dimethylamide 9.1
6-chloronicotinamide 8.7
20CF3-LTB4 8.7
6-chloronicotinamide 8.7
C20H30O3 8.3
DPT 8.2
Guanadrel 8.1
2-hydroxytetradecanoic acid 8.1
piperidine oxalate 8.1
K-DR 7.9
3-ethyl-1H-indole 7.9
5-isoquinolinesulfonic acid 7.9
8-Cyclopentyltheophylline 7.9
3,4-D 7.6
Sulmazole 7.5
3-hydroxyhexadecanoic acid 7.4
2,5-pyrrolidinedione 7.3
LY 294002 7.3
Sphingosine 1-phosphate 7.2
Dexamethasone acetate 7.2
Inositol phosphate 7.2
1-amino-1,3-cyclopentanedicarboxylic acid 7.2
G11 7.2
2-(4-morpholinyl)ethyl 7.1
fMet 7.1
Muscarine 7.1
8-(diethylamino)octyl 3,4,5-trimethoxybenzoate 7.1
Himbacine 7.1
Polymyxin B sulfate 7.1
2-(4-morpholinyl)ethyl 7.0
S 10 7.0
1,3-benzenedisulfonic acid 7.0
1,3-benzenedisulfonic acid 7.0
1H-pyrrole-2,5-dione 6.9
2-amino-4-phosphonobutanoic acid 6.9
1,3-cyclopentanedicarboxylic acid 6.9
3-aminopropylphosphonic acid 6.9
2-amino-4-phosphonobutanoic acid 6.9
Palmitoyl-L-carnitine 6.9
PRN 6.8
202-791 6.8
PD 168 6.8
GF 109203X 6.7
2-hydroxydodecanoic acid 6.7
Erythromycin ethylsuccinate 6.7
diphosphoric acid 6.7
GTP 6.6
Ap(6)A 6.6
FMLP 6.6
Joro spider toxin 6.5
Carbachol 6.5
Etorphine 6.5
inositol 1,4-bisphosphate 6.5
3,4,5-trimethoxybenzoic acid 6.5
3-butyn-1-ol 6.5
SP-G 6.5
butylcyclohexane 6.4
1,8-octanediamine 6.4
Neomycin sulfate 6.4
Amaranthin 6.3
GDP 6.3
Neomycin sulfate 6.3
8-aminooctanoic acid 6.3
DAMGO 6.2
Forskolin 6.2
cyclopentyl 6.2
20-COOH-LTB4 6.2
DAMP 6.2
Succinimide 6.1
Gramine 6.1
ADP 6.1
ADP 6.1
2-methylpiperazine 6.1
Leucine enkephalin 6.1
Phorbol 12-myristate 13-acetate 6.1
Formycin A 6.1
GMDP 6.1
Flavoxate 6.0
more...