Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0043167 (
pertussis
)
19,595
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Mannan-binding protein
(
MBP
) is a Ca(2+)-dependent mammalian lectin that plays an important role in innate immunity. In this study, we found that ligand-bound
MBP
stimulates polymorphonuclear leukocytes (PMN) to induce cell aggregation and superoxide production. The biological response of PMN to ligand-bound
MBP
was dose- and time-dependent. The PMN aggregation and superoxide production induced by ligand-bound
MBP
was blocked completely by
pertussis
toxin, and partially blocked by a platelet activation factor receptor antagonist, TCV-309. These findings suggest that the ligand-bound
MBP
stimulates PMN through a putative
MBP
receptor(s) on PMN.
...
PMID:Superoxide production from human polymorphonuclear leukocytes by human mannan-binding protein (MBP). 1546 4
