Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0043167 (
pertussis
)
19,595
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Cefpiramide (
CPM
, SM-1652) had broad-spectrum antibacterial activities against most of clinically isolated organisms to which are paid attention as pathogenic organism in the field of pediatrics. Antibacterial activities of
CPM
against Staphylococcus aureus, Streptococcus pyogenes, Haemophilus influenzae, Bordetella
pertussis
and Proteus mirabilis were almost the same as those of cefoperazone (CPZ). Antibacterial activities of
CPM
against Escherichia coli and Klebsiella pneumoniae were somewhat weaker than those of CPZ, but antibacterial activity of
CPM
against Pseudomonas aeruginosa was rather stronger than that of CPZ and almost the same as that of cefsulodin. Antibacterial activity of
CPM
has a tendency to decrease in beta-lactamase (PCase type) producing S. aureus, E. coli, K. pneumoniae, H. Influenzae, etc. It is suggestive that the determination of not only the antibacterial activity of
CPM
against pathogenic organisms but also the beta-lactamase producing activity of them is important on the occasion of clinical use of
CPM
.
...
PMID:[Susceptibility of clinical isolates in pediatrics to cefpiramide]. 665 31
