Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0043167 (pertussis)
 19,595 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Tiopronin enhances migration of polymorphonuclear leukocytes (PMNs). The enhancing effect consists partly of a chemokinetic, and partly of a chemotactic effect. Intact sulfhydryl groups on the outer surface of the PMN plasma membrane are required for the enhanced locomotion: pretreatment of cells with the non-penetrating sulfhydryl reagent (5,5'-dithiobis(2-nitrobenzoic acid) completely abolishes the activating effect of tiopronin, but has only a moderate effect on activation by fMet-Leu-Phe. Pretreatment of PMNs with pertussis toxin inhibits tiopronin-induced enhancement of migration, suggesting that a pertussis toxin-sensitive G-protein is involved in the enhancing effect of tiopronin on PMN migration.
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PMID:Tiopronin (2-mercaptopropionylglycine) has chemokinetic and chemotactic properties for polymorphonuclear leukocytes. 160 42

Tiopronin (50 mg/kg) and D-penicillamine (50 mg/kg) do not exhibit anti-inflammatory effects in classic animal models (carragenin oedema, granuloma cotton pellets) but suppress pertussis vaccine oedema, an immunological model, when given with a long-lasting dosing regime. Tiopronin and D-penicillamine also fail to inhibit PG release by phagocytosing leucocytes when the concentrations used were in the same range as human blood levels (5-15 micrograms/ml). Indomethacin (1, 3 and 5 mg/kg) instead significantly inhibits both the in vivo and in vitro models considered. This may imply a different mode of action of both tiopronin and D-penicillamine from indomethacin. Tiopronin also possesses similar effects to D-penicillamine suggesting that their overall anti-rheumatic action may have common elements.
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PMID:Some pharmacological properties of tiopronin. 734 Apr 66