Gene/Protein
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Symptom
Drug
Enzyme
Compound
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Target Concepts:
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Query: UMLS:C0043167 (
pertussis
)
19,595
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Lysophosphatidylethanolamine (LPE), a lyso-type metabolite of phosphatidylethanolamine, has been reported to be an intercellular signaling molecule. LPE mobilizes intracellular Ca
2+
through G-protein-coupled receptor (GPCR) in some cells types. However, GPCRs for lysophosphatidic acid (LPA) were not implicated in the LPE-mediated activities in LPA GPCR overexpression systems or in SK-OV3
ovarian cancer
cells. In the present study, in human SH-SY5Y neuroblastoma cells, experiments with LPA
1
antagonists showed LPE induced intracellular Ca
2+
increases in an LPA
1
GPCR-dependent manner. Furthermore, LPE increased intracellular Ca
2+
through
pertussis
-sensitive G proteins, edelfosine-sensitive-phospholipase C, 2-APB-sensitive IP
3
receptors, Ca
2+
release from intracellular Ca
2+
stores, and subsequent Ca
2+
influx across plasma membranes, and LPA acted on LPA
1
and LPA
2
receptors to induce Ca
2+
response in a 2-APB-sensitive and insensitive manner. These findings suggest novel involvements for LPE and LPA in calcium signaling in human SH-SY5Y neuroblastoma cells.
...
PMID:Calcium Signaling of Lysophosphatidylethanolamine through LPA
1
in Human SH-SY5Y Neuroblastoma Cells. 2730 65
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