Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0043167 (pertussis)
 19,595 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

During the primary diarrhea season (December 1987-April 1988) in metropolitan Porto Alegre in southern Brazil, researchers compared 192 children aged less than 2 years who were admitted to a hospital with moderate or severe dehydration with 192 neighborhood- and age-matched controls who had a diarrhea episode without dehydration during the seven days before the interview. They aimed to identify factors predicting life-threatening dehydration. When the researchers controlled for age and other confounding variables, the following factors were significantly related to an increased risk of dehydration: no father in the household, low paternal education level, young age, maternal age 25-29 years or less than 20 years, mixed race mother, high birth order, short birth interval, low birth weight, stunting, underweight and wasting, non-breast milk, children aged less than 5 in the household, family size of 4-5, no prenatal care, less than three doses of diphtheria-pertussis-tetanus or poliomyelitis vaccine, previous admission to a hospital, use of medicines during the two weeks before the diarrhea episode, and living in an unsanitary household. The strongest factors associated with an increased risk of dehydration (p 0.001) included young age, low birth weight and malnutrition, short birth interval, and non-breast milk. These factors were not as effective at predicting an increased risk of dehydration as early signs and symptoms. Specifically, their sensitivities were lower than those of early signs and symptoms. Notwithstanding, these findings support current efforts towards promotion of breast feeding, prevention and treatment of malnutrition, and birth spacing since they contribute to the prevention of diarrhea-related dehydration.
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PMID:Breast-feeding, nutritional status, and other prognostic factors for dehydration among young children with diarrhoea in Brazil. 139 80

Between February and April 1995, 669 under-five children living in Jimma town were randomly selected and had their nutritional status assessed. Risk factors for protein-energy malnutrition (PEM) were also studied. About half (48%) of the children were found to be malnourished. The prevalence of underweight, wasting and stunting were 36%, 9% and 36%, respectively. Severe protein-energy malnutrition, i.e., marasmus, kwashiorkor and marasmic-kwashiorkor, was detected in 2%. The prevalence of malnutrition was lowest in infants. While underweight and wasting peaked by the second and third years of life, stunting increased dramatically by the second year and peaked in the fifth year. Poor socio-economic background, poor housing condition, non-availability of latrine, "unprotected" water source, an attack of pertussis, not completing immunization, prolonged breast feeding and nutritionally inadequate diet were found to be risk factors for PEM in the bivariate analyses. Multiple logistic regression analyses showed a strong association between PEM and poor housing condition, non-availability of latrine, prolonged breast feeding and diet lacking in animal food. Intervention measures should take the multifactorial causation of PEM into consideration.
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PMID:Protein-energy malnutrition in urban children: prevalence and determinants. 1021 56