Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0043167 (pertussis)
 19,595 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An 8-month-old child underwent a muscle biopsy because of hypotonia. The biopsy showed centronuclear myopathy and, in addition, an unusual granulomatous inflammatory infiltrate. The child died of respiratory complications and a complete autopsy failed to reveal further evidence of granulomatous disease. The lesion was reproduced in experimental animals by intramuscular injection of diphtheria and tetanus toxoids and pertussis vaccine. Granular material present in histiocytes in these lesions was shown histochemically to be an aluminum salt.
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PMID:Muscle granulomas following intramuscular injection. 715 75