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Query: UMLS:C0043167 (pertussis)
 19,595 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Two hundred children aged 2-24 months attending EPI Centre Rawalpindi General Hospital, were randomly assigned to two basic immunization schedules i.e. 3 doses of oral polio vaccine alongwith two doses of DPT (Conventional Schedule) and 2 doses of combined DPT - enhanced injectable polio vaccine (new simplified schedule). Comparison of the seroconversion results showed the presence of protective antibodies against all the 3 types of polio in 100% of the children in both the groups, but there was no statistical difference in the geometric mean antibody titre in the two immunization schedules. After two doses of DPT-IPV or DPT vaccine alone the results demonstrated antibody levels above the protective threshold in both the groups against Diphtheria, Pertussis and Tetanus.
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PMID:Comparison of immunogenicity of combined DPT--inactivated injectable polio vaccine (DPT - IPV) and association of DPT and attenuated oral polio vaccine (DPT + OPV) in Pakistani children. 249

In accordance with a World Health Assembly resolution of 1974, all children of the world are to be immunized by the year 1990. Thus was the origin of world wide Expanded Program for Immunization (EPI). Currently, this program prevents 2 million deaths from measles, pertussis and neonatal tetanus, and 1/4 a million deaths from paralytic poliomyelitis each year. Nevertheless, nearly 3 million children die, 200,000 are paralyzed and 150,000 are blinded by diseases which are preventable by immunization. Measles alone kills 1.6 million children each year and vaccination against it reduces child mortality by 30%. Added to the problems of maintaining an effective cold chain, and provision of managerial guidance for the distribution of vaccines, is the fact that measles vaccine can only be administered at 9 months age or older. However, current work on vaccines is focused on the development of a high titer of a more immunogenic measles vaccine which can be administered at 6 months of age. In spite of further potential for improvement in existing vaccinations and the development of new vaccines, resources are limited for such advancement. This limitation is partly due to misallocation of monetary resources, where priority is given to armament projects, instead of directing the funds to programs that save lives.
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PMID:Saving children's lives by vaccination. 251 92

To focus attention on the problem of infant mortality in Lebanon, data were compiled on infant mortality from 1978 to 1986 at the American University of Beirut Medical Center. Causes of death are analyzed for 602 males and 398 females. 54.9% deaths occurred at 1 month of age and 77.4% died within the 1st year. Autopsies were performed on .7%. 37.7% of all neonatal deaths were due to neonatal diseases such as hyaline membrane disease, asphyxia neonatorum, immaturity, necrotizing enterocolitis, hemorrhage, hemolysis, meconium aspiration, and kernicterus. Better prenatal care would reduce this group, or the administration of corticosteroids to the mother 24-48 hours prior to delivery, as well as rapid resuscitation at birth and prevention of the 5 curses: hypoxemia, hypoglycemia, hypothermia, hypotension, and acidosis. Although unavailable in Lebanon, administration of surfactants through an endotracheal tube would also help. Infections constitute 25.1% of deaths; many are preventable through adequate public health measures and strict personal hygiene, i.e., diseases such as sepsis, pneumonia, meningitis, gastroenteritis, hepatitis, encephalitis, and 1-2 cases of the following: diphtheria, measles, peritonitis, tetanus, tuberculosis, cytomegalis inclusion, herpes, parathyphoid, pertussis, poliomyelitis, and shigellosis. Congenital diseases were 21.6%. In utero diagnosis could prevent some diseases and in utero treatment is possible for hydrocephalus and hydronephrosis. Screening programs postnatally could lead to treatment. 5.9% were malignancies such as leukemia, lymphoma, brain tumors, histocytosis, Wilm's tumor, Ewing sarcoma, and Hodgkin's disease. Early diagnosis is critical if mortality is to be reduced in this group, but medical advances are still needed. 2.9% are miscellaneous diseases such as poisoning, rheumatic diseases, marasmus, Reye's syndrome, nephrosis, rickets, and epilepsy. Most of these diseases are preventable, except for rheumatic inflammation of the heart. Recommended necessary steps to reduce infant mortality are: prenatal care, diagnosis and screening, intrauterine surgery; resuscitation and intensive care centers with modern equipment and trained personnel; national vaccination and screening programs; adequate public health measures and hygiene; parental education; and well-equipped hospitals to serve all regardless of income level.
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PMID:Pediatric mortality: an avoidable tragedy. 251 28

Fifty one preterm infants (26-36 weeks' gestation) were enrolled in a study of their immunological responses to diphtheria, tetanus, pertussis, and polio antigens eight to 12 weeks after their primary courses had been completed. Samples from 21 infants born at full term were also analysed. Many infants were able to start immunisation at 3 months of age. Premature infants who are immunised as soon as possible after 3 months of age develop adequate antibody responses.
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PMID:Routine immunisation of preterm infants. 255 22

During the first month of life 28 full-term newborns were breast-fed (18 males and 11 females). Thereafter 8 infants continued breast-feeding while the remainder were randomly fed on either an adapted milk formula (n=13) or a soy-formula (n=7). At five months, after an oral dose of RIT 4237 rotavirus vaccine of bovine origin was given, growth and IgM/IgG type antibodies against rotavirus were measured. Weight gain was similar in all infants. There were 2 IgM and 1 IgG responders out of 7 soy fed infants, compared with 4 out of 8 human milk fed (both IgM and IgG) and 7 out of 13 IgM and 6/12 IgG formula fed infants responding to vaccination. This observation confirms previous results obtained with polio, diphtheria tetanus and pertussis vaccines indicating that soy-protein formulas may interfere with immunization processes.
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PMID:Response to RIT 4237 oral rotavirus vaccine in human milk, adapted-and soy-formula fed infants. 255 83

A cohort of 522 children entering primary school were reviewed for contraindications to immunisation. Every child in the group would have been eligible to receive diphtheria, tetanus, polio, and measles immunisation if the current (1988) Department of Health and Social Security (DHSS) guidelines had been followed. Only 2.5% of the cohort met the DHSS contraindications to pertussis immunisation.
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PMID:Incidence of contraindications to immunisation. 262 28

The national immunization coverage in Thailand for all types of vaccine has been steadily increasing since 1978, when the EPI was formally launched. The coverage in 1987 was 96% for BCG, 75% for DPT, 74% for OPV, and 60% for TT. Measles vaccine, which started only in late 1984, had the lowest coverage, 51%, in 1987. During the period 1982-1987, the drop-out rates between the first and third dose of DPT and OPV decreased dramatically from 69% to 13% and from 42% to 13% respectively. Sampling surveys of immunization coverage showed higher coverage for DPT and OPV than those from reporting in all regions, especially in the capital city which has a high concentration of the private health sector. Only the northeastern region had less coverage from surveys than from reporting. Following the launch of EPI, the disease incidence demonstrated a clearly downward trend for diphtheria, poliomyelitis, and measles, while in the case of pertussis and neonatal tetanus, slower of still fluctuating declines were observed. The reported age-specific incidences per 100,000 population in 1986 for children 0-4 years were as follows: 4 for diphtheria, 0.9 for poliomyelities, 180 for measles, 14 for pertussis, and 10 for tetanus.
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PMID:Thailand Expanded Program on Immunization: a ten-years review of coverage and impact on EPI target diseases. 263 10

We studied the incidence of typhoid fever, hepatitis, poliomyelitis, scarlet fever, pertussis and measles from 1954 to 1984 as reported in the yearly records of diseases subjected to compulsory notification. Autocorrelation functions and Fourier analysis were used to study incidence fluctuation. Seasonal variations related in all cases to pathogenic factors were found for all diseases. Air borne transmission was related to a peak incidence in spring and enteric transmission in summer. Person to person transmission and crowding at school are noted as factors influencing the incidence pattern of hepatitis and scarlet fever.
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PMID:[Ecologic dynamics of infectious diseases. I. Seasonal variations]. 264 29

The incidence of hepatitis, mumps, poliomyelitis, scarlet fever, pertussis and measles from 1954 to 1984 was studied from the annual records of infectious diseases. Fluctuations were evaluated by Fourier analysis. Periodic recurrency was detected for poliomyelitis, scarlet fever, pertussis and measles and was likely for mumps. The asynchronic fluctuation of the proportion of cases and susceptible individuals is considered to be the origin of this phenomenon. Observed fluctuations corresponded to those predicted by the models.
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PMID:[Ecologic dynamics of infectious diseases. II. Periodic recurrence of epidemics]. 264 30

The safety and immunogenicity of a Haemophilus influenzae type b conjugate vaccine was investigated in 103 infants immunised at 3, 5, and 9 months of age; the infants also received diphtheria, pertussis, and tetanus and polio vaccines. Side effects were compared with 99 matched infants receiving diphtheria, pertussis, and tetanus and polio vaccines only. No serious side effects were observed and the incidence of minor side effects was no greater in the recipients of H influenzae type b conjugate vaccine. Two doses of the vaccine (standard and low) were compared: geometric mean titres of serum anticapsular antibody rose from 0.11 microgram/ml before immunisation to 26.4 micrograms/ml after three immunisations with the standard dose and 14.6 micrograms/ml with the low dose. The geometric mean titre among 21 unimmunized infants at this age was 0.06 micrograms/ml. Both doses therefore generated antibody concentrations likely to be protective after three immunisations. There were no non-responders. Incorporation of an H influenzae type b conjugate vaccine into the primary immunisation schedule has the potential for preventing over 1000 cases of systemic H influenzae type b disease and 50 deaths each year in the United Kingdom.
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PMID:Haemophilus influenzae type b conjugate vaccine trial in Oxford: implications for the United Kingdom. 266 57


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