Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0043167 (pertussis)
 19,595 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An 18-month-old infant developed hemiseizure-hemiplegia syndrome following a booster dose of vaccine against diphtheria, pertussis, tetanus, and poliomyelitis. Clinical, CT scan, and electroencephalographic findings during the two-and-a-half-year follow-up are described. The timing of events and data from the literature suggest that hemiseizure-hemiplegia syndrome is related to post-immunization hyperthermia rather than to direct neurologic toxicity of the vaccine.
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PMID:[Post-vaccinal hemi-convulsion hemiplegia syndrome]. 175 Jul 49

In France, infants are immunized against paralytic poliomyelitis with enhanced-potency inactivated poliovirus vaccine (eIPV) combined with the diphtheria-tetanus-pertussis vaccine (DTP). Ninety-five percent of all infants in France have received four doses of DTP-eIPV by 24 months of age. No cases of vaccine-associated paralysis, among either recipients or those in contact with recipients, have been reported since 1983, when eIPV became the vaccine of choice. Only three wild indigenous cases have been reported among unvaccinated children in 1988 and 1989, with no cases reported in 1990. Although paralytic poliomyelitis has been virtually eliminated in France, vaccination programs as well as active surveillance of the community and environment for poliovirus circulation should be reinforced to reach the goal of wild poliovirus eradication.
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PMID:Poliomyelitis in France: epidemiology and vaccination status. 176 23

A prospective study of minor reactions after the four combined vaccinations for diphtheria, tetanus, pertussis, and poliomyelitis (DTPP) was performed in 540 infants in the Netherlands. An analysis was made of the symptoms observed by the infants' parents after 2026 inoculations. The aim was to assess the frequency, association, and risk of recurrence of minor reactions. These were designated as fever (greater than or equal to 38.0 degrees C), local reactions, crying, and other general symptoms (changes in sleeping or eating patterns, vomiting, drowsiness, fretfulness). Fever occurred after 67.7% of inoculations, one or more local reactions after 66.2%, and increased crying after 64.4%. After 80% of inoculations, one or more other general symptoms occurred. Only 4.4% of inoculations were followed by no minor reaction. Fever rarely occurred as an isolated symptom; it showed a significant association (i) with one or more local reactions, (ii) with increased crying, and (iii) with two or more other general symptoms. Chances of fever, redness at the inoculation site, and crying after inoculation increased with repeat inoculations if these reactions had occurred after preceding inoculation(s).
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PMID:Frequent symptoms after DTPP vaccinations. 177 87

A community survey was conducted in 1989 in Conakry, Guinea to determine reasons for low vaccination coverage. Some 377 children aged 12-23 months and their guardians were studied, of whom 204 (54%) had vaccination records. According to their records 19% of children were fully and correctly vaccinated. Thirty-nine incompletely vaccinated children (19% of those with records) had sufficient documented contacts with health services to be fully vaccinated, but at least one immunization opportunity was missed. Multivariate analyses were conducted to identify factors associated with receipt of first dose diphtheria/pertussis/tetanus/oral polio vaccine (DPT/OPV) and with completion of the DPT/OPV series. Factors determining initiation of the series included maternal education (assessed by ability to speak French), household possession of a television, maternal age less than 35 years, child's birth in hospital, and, for non-French speakers, the mother considering vaccination to be affordable. Factors determining completion of the DPT/OPV series, among children who began vaccination, included maternal education, employment, and past positive experience with vaccination services (short waiting times, not having been turned away from vaccination, and not knowing a child with a post-vaccine 'abscess'). Vaccination coverage can be substantially increased in Conakry by improving health services to avoid missed opportunities, following the vaccination schedule correctly, reducing waiting times and avoiding abscesses.
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PMID:Determinants of vaccination in an urban population in Conakry, Guinea. 180 Apr 10

The Expanded Programme on Immunization in Togo began in 1980 in the provinces and extended to the whole country in 1984. At the present time, the immunization coverage of children under one year of age is of 43% and 63% for the tetanus immunization of women. The epidemiological impact is being notable on the incidence of measles, tetanus, pertussis and poliomyelitis but efforts are still necessary for mothers' information.
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PMID:[The enlarged program of vaccination in Togo (1980-1990). Realities and perspectives]. 181 30

Contrary to the regular immunization schedule for children, the majority of immunization are done in adulthood in case of special risks only, such as old age, chronic illness or exposure. The protection against a variety of communicable diseases has to be monitored and if necessary to be boosted regularly. Based on the routine vaccination scheme 1991 of the Federal Department of Public Health, the following vaccinations which are commercially available in Switzerland are discussed in this review: diphtheria, Haemophilus influenzae, hepatitis B, influenza, measles + mumps + rubella, meningococci, pertussis, pneumococci, poliomyelitis, tetanus, rabies, tuberculosis, varicella and tick encephalitis. Furthermore, the current recommendations are given for the prophylactic and therapeutic use of immunoglobuline preparations.
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PMID:[Active and passive immunization: 1991 status]. 185 65

Immunization practice in 32 countries in Europe, North America, Japan, and Australia is reviewed. in most countries, immunization practices are set by the federal government which sometimes works with the private sector. Almost all countries routinely immunize against diphtheria, tetanus, whooping cough, polio, and measles. About half try to prevent rubella, several try to prevent mumps, usually in combination with measles and rubella (MMR). More than half use bacillus Calmette-Guerin (BGG) vaccine to prevent tuberculosis, and a few give Hemophilus Influenza type B polysaccharide. Poliomyelitis vaccine comes in 2 forms: 1) oral live attenuated (OPV) or injectable inactivated (IPV). OPV is more used, but there is a new "enhanced potency IPV." All countries except Japan give DPT in 3 doses during the 1st year of life. OPV is usually given at the same time that DPT is. Measles vaccine or MMR is usually given between 12 and 18 months of age. Primary vaccine failure occurs in 2-5% of people who get measles vaccine, but this may be enough to "sustain transmission." In most countries, the government provides for immunizing children. An exception in the US. In the UK, low coverage has taken place because of concern for adverse reactions (whooping cough) or lack of appreciation of the disease's impact (measles). Coverage against both measles and pertussis has improved in the UK lately. In each developed country, vaccines have had "spectacular" effects. However, there are too many contraindications and there is "undue fear of adverse events." Also, there are surveillance deficiencies, a lack of coordination, and countries vary in their commitment to "reduction/elimination targets." Varicella vaccine, respiratory syncytial virus vaccine, and rotavirus vaccine are being considered for universal use. Attempts are being made to improve the safety of some vaccine.
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PMID:Immunisation practice in developed countries. 196 69

Researchers interviewed 194 mothers of children 1-2 years old in Port Moresby, New Guinea to determine why childhood immunizations are not completed. They also looked at the baby clinic books to see if the children received the completed doses of vaccines. 87% did not know why children should be immunized. Moreover only 13% believed immunizations could prevent disease. Further 86.6% could not list any of the diseases that immunizations target. 11.9% did correctly report measles, tuberculosis, polio, and pertussis, however. On the other hand, 3 (1.5%) mothers incorrectly believed immunizations protect against malaria, diarrhea, and malnutrition. The relationship between lack of knowledge and noncompletion of immunization was not significant, however (p=.07). 76.8% reported very rude behavior on the part of the health staff. 15.5% went so far to say that the health staff often reacted aggressively towards them. Only 7.7% reported kind of behavior. Mothers who perceived health staff attitudes as negative tended not to return to the clinic with their children for the 3rd dose (p=.002). DPT and polio vaccine coverage declined consistently from 94% (1st dose) to 79% (3rd dose). Nevertheless 3rd dose coverage was considered rather high. Since hospital delivery was almost universal in Port Moresby and hospital staff routinely administer the BCG vaccination prior to discharge, BCG coverage was high (96%), however. Emphasis in the national immunization program should be on changing health staff attitudes leading to improvements in the social interaction between patients and health staff.
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PMID:Possible reasons for non-completion of immunization in an urban settlement of Papua New Guinea. 205 99

Childhood immunization in Iran was assessed by a WHO EPI (World Health Organization, Expanded Program on Immunization) cluster survey method covering 2118 children aged 12-23 months in 1987. Complete immunization was defined as a minimum of 3 DPT (diphtheria, pertussis, tetanus), 3 OPV (oral polio vaccine), 1 BCG (Bacillus Calmette-Guerin), and 1 live attenuated measles vaccine by age 1 year. Iran's Primary Health Care system consists of a rural branch operated by mobile male and female teams, and an urban branch still in the process of changing from cure-oriented care to emphasis on health education, nutrition, and maternal-child health services. Complete immunization coverage by age 1 was better in rural areas, 44.1%, than in urban areas, 28.2%, and Teheran 34.9%. There was no relationship between immunization coverage and infant mortality rate, which is dominated by diarrhea. The reason for better coverage in rural areas is that village workers actively search out, visit and immunize children, while in urban areas provide physicians dominate care, but do not insist on immunization. Furthermore, in Teheran, BCG is not routinely given, which lowered the overall immunization coverage rate there.
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PMID:Primary health care and immunisation in Iran. 206 95

This paper is a partial cost-minimization analysis of preschool immunization delivery in Alberta and Ontario. Public health nurses deliver such immunization in Alberta while in Ontario it is usually provided by private physicians. In constant 1986 dollars, labour costs were 2.9 times higher in Ontario than in Alberta. Alberta and Ontario achieved equal success in preventing diphtheria, tetanus and poliomyelitis in the target population of zero to four years of age. Ontario's pertussis rates were higher than Alberta's from 1980 to 1986 inclusive (p less than 0.01). Rubella rates were higher in Alberta from 1980 to 1986 inclusive (p less than 0.05) but the congenital rubella rates for the same period were not. During 1980, Ontario's measles rate was higher (p less than 0.01) while for 1982 and 1986, Alberta's measles rates were higher. In 1986, Alberta's mumps rate was higher than Ontario's (p less than 0.01). The findings argue in favour of the less costly public health nurse approach to immunization delivery. A more definitive conclusion could have been reached had the provinces maintained more detailed age-specific disease incidence data.
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PMID:Infant and preschool immunization delivery in Alberta and Ontario: a partial cost-minimization analysis. 211 28


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