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Query: UMLS:C0043167 (pertussis)
 19,595 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Vaccination by whole-cell pertussis vaccine (Pw) since forties years was followed by decreasing of morbidity and especially mortality caused by pertussis. High reactogenicity of this vaccine (Pw) was the reason trials undertaken to search new type of less reactogenic vaccine. Acellular pertussis vaccine (Pa) was found as effective, safe, small reactogenic. It may be especially used as booster doses for older children and even for adults people. Actual pertussis infection among adults are suspected as the source infection for children. Just now in some countries acellular vaccine start to be used for ground vaccination of children. Increasing of morbidity of pertussis was noted in some provinces in Poland in last time. Acellular pertussis vaccine may be introduced as booster dose for 6-7 years old children, if epidemiological situation of pertussis among school-age children would be not satisfied in future.
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PMID:[Acellular pertussis vaccine (Pa)]. 749 31

The reproducibility of laboratory methods, recommended by WHO and used by manufacturing and control institutions of most countries for the evaluation of the immunogenic potency of the pertussis, diphtheria and tetanus components of adsorbed DPT vaccine in the process of its production, was studied. This immunogenic potency was experimentally studied in comparison with the immunogenic potency of national standard samples from Bulgaria, Czechoslovakia, Hungary, Poland and Russia. The results of this study indicated that the coded commercial lots of adsorbed DPT vaccine corresponded to WHO requirements with respect to the immunogenic potency of all their components. At the same time, according to data provided by different laboratories, the indices of their immunogenic potency varied within rather wide limits. Taking into account the necessity of dosing all components of adsorbed DPT vaccine by immunizing (protective) units, the reliability of the recommended control methods should be enhanced by the maximum standardization of all testing conditions and the organization of periodic workshops on the basis of the leading WHO laboratory with a view to improving the qualification of specialists carrying out the quality control of commercial lots of adsorbed DPT vaccine.
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PMID:[The standardization of the methods for assessing the immunogenic activity of all of the components of an adsorbed DTP vaccine]. 806 22

In Poland vaccination against diphtheria, tetanus and pertussis (DTP) is recommended from 2-3 months of age. Three doses at approximately 6-week intervals are given. A booster dose of DTP is given at 19-24 months and boosters of DT at 6 and 14 years. In this study serum samples were obtained from 166 Polish children aged 2 weeks to 14 years. Vaccination status was verified from the children's Health Books. Antibodies were determined against pertussis toxin, filamentous hemagglutinin (FHA), pertactin, tetanus toxoid and diphtheria toxin. Antibodies of maternal original against all five antigens were detected in almost all sera from infants not yet vaccinated. Antibody levels increased with the number of vaccinations given. Children who had recently received the fourth vaccination had the highest antibody levels. Antibody levels decreased with time after the fourth vaccination for all antibodies except FHA. It was concluded that the Polish whole cell pertussis vaccine stimulates antibodies against pertussis toxin, FHA and pertactin, but that antibodies against FHA probably also are stimulated by cross-reacting antigens. Diphtheria toxin and tetanus toxoid antibodies were above protective levels in all vaccinated children, but the long-term decreases justify the booster dose at 14 years. Twenty-five of 166 children (15%) had a vaccination status which deviated from recommendations demonstrating a need to increase the vaccination rate.
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PMID:Serum antibodies to the components of diphtheria-tetanus-pertussis vaccine in Polish children related to vaccination status. 852 78

In many industrialized countries pertussis has been successfully controlled due to introduction of immunization programmes. However, decline trends in pertussis incidence, observed since more than 20 years, has been recently halted in individual countries, including Poland. In some industrialized countries, even absolute increase of pertussis incidence is recorded. Important changes in age distribution of pertussis patients are noted; from one side, there is an increase of pertussis incidence in infants, and a slow but continuous shift towards older age. There is an increasing body of evidence that adults may be the main reservoir of pertussis organisms and play an important role in the transmission of pertussis infection to younger children. Studies on the role of adults in transmission of pertussis infection to younger children should be undertaken in Poland. Early beginning and early completion of series of primary immunizations with DTP vaccine in infants and maintainance of a high immunization coverage with all doses of DTP vaccine specified in the immunization calendar are needed to successful control of pertussis. There is an urgent need to improve the diagnosis of pertussis in Poland, and especially the bacteriological confirmation of the diagnosis.
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PMID:[Can we control pertussis better? I. Changes in the epidemiology of pertussis]. 941 98

Although in many countries pertussis had been successfully controlled by the routine mass immunization in infants and children, the disease continues to cause extensive morbidity and mortality throughout the world. Whole-cell pertussis vaccine plays an important role in the control of pertussis in the world and the vaccine proved to be very successful during nearly 50 years of its use. However, the whole-cell pertussis vaccine causes an increased rate of local and general adverse events although many of these events described as caused by vaccination are occurring co-incidentally, not being related to vaccination. Results of recent clinical and field trials in the USA, Sweden, Italy, Germany and Senegal showed that acellular pertussis vaccines are effective in preventing pertussis in children and safe in infants. However, a crucial issue in more general use of acellular pertussis vaccine is its availability and its price. It may be prove too expensive for many countries, including Poland. The cost can be expected to decrease in the future, when the production capacity and the number of doses used increase. The introduction of acellular pertussis vaccine in the immunization programme in Poland will need several organizational, technological and scientific actions.
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PMID:[Can we control pertussis better? II. Old and new vaccines against pertussis]. 941 99

To assess the impact of anti-vaccine movements that targeted pertussis whole-cell vaccines, we compared pertussis incidence in countries where high coverage with diphtheria-tetanus-pertussis vaccines (DTP) was maintained (Hungary, the former East Germany, Poland, and the USA) with countries where immunisation was disrupted by anti-vaccine movements (Sweden, Japan, UK, The Russian Federation, Ireland, Italy, the former West Germany, and Australia). Pertussis incidence was 10 to 100 times lower in countries where high vaccine coverage was maintained than in countries where immunisation programs were compromised by anti-vaccine movements. Comparisons of neighbouring countries with high and low vaccine coverage further underscore the efficacy of these vaccines. Given the safety and cost-effectiveness of whole-cell pertussis vaccines, our study shows that, far from being obsolete, these vaccines continue to have an important role in global immunisation.
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PMID:Impact of anti-vaccine movements on pertussis control: the untold story. 965 34

Decreasing of number of cases as well as incidence rate of hepatitis type B and type A, and increasing of pertussis, leptospirosis, encephalitis and some other diseases was noted in Poland in 1997. The biggest percentage of deaths was caused by tuberculosis--43.1%, sepsis--over 21.9% and hepatitis--10.6%. Introduction of ICD-10 as well as strikes of health workers in Poland in 1997 caused undernotification especially of deaths.
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PMID:[Infectious diseases in Poland in 1997]. 1040 44

In 1997 an epidemic increase of pertussis was observed in Poland. The incidence was 5.4/100,000 population and was more than six times higher than in the preceding year. No clear reason for a sudden increase in pertussis incidence was found, in particular the vaccination coverage rates have remained high. In December 1997 the DTP vaccine coverage rate for children below two with four doses of DTP was 97.5%. The distribution of cases according to age during the last 20 years was analysed and it was shown that since the beginning of the '90 a growing proportion of cases occurs among fully vaccinated children and the average age of the cases has a steadily growing tendency. A hypothesis was put forward that the come-back of pertussis is presently due to waning of short-term immunity following immunisation, in cohorts of children who grew up in conditions of very low B. pertussis natural transmission. An open question remains whether to introduce to the immunisation calendar an additional booster dose of pertussis vaccine in school-aged children.
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PMID:[Pertussis in 1997]. 1040 46

In 1998 further global increase in reported cases of pertussis in Poland was observed. The total number of reported cases was 2871 including 854 cases reported in 1998 which occurred in 1997. Most of the cases accumulated in first quarter of the year, with subsequent decrease in the second half of the year, to the level below observed in 1997 in the same seasons. So the most evident increase of the incidence of pertussis was present in the last two quarters of 1997 and first quarter of 1998. Observed temporary increase of pertussis incidence occurred without any significant changes in vaccination coverage and does not seem to be related to changes in vaccine effectiveness. In last two years increased incidence of pertussis was observed in all age groups, but in older ones: 5-9, 10-14 increase in incidence was higher (Table III). Major problem in reporting of pertussis in Poland is small fraction of cases confirmed by culture or by ELISA test, which brings possibility of small specificity of diagnostic procedures used.
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PMID:[Pertussis in 1998]. 1107 43

Improvement of epidemiological situation of infectious diseases was continued in Poland in 1999. The end of epidemics of measles, pertussis, mumps, scarlatine, chickenpox, and rubella was observed. In comparison with the number of cases of infectious diseases registered in 1998, decrease in the number of notified cases of salmonellosis, dysentery, meningitis, encephalitis, and hepatitis type B and A as well as increase in the number of influenza cases and trichinosis was noticed. In 1999, compared with 1998, among all notified deaths percentage of deaths attributed to infectious diseases (0.80%) and infectious diseases death rate (7.71 per 100,000) were slightly higher as an effect of the influenza deaths increase.
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PMID:[Infectious diseases in Poland in 1999]. 1155 72


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