Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0043167 (pertussis)
 19,595 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In a controlled field-trial in infants in the Philippines, a two-dose schedule with an interval of 6 months between injections using a concentrated adsorbed DPT-vaccine was evaluated. The serologic response against the three components in the vaccine was satisfactory, whereas the side-effects in the concentrated vaccine group did not differ from those observed in a control DPT group. After two injections, the coverage percentage with DPT-vaccine was shown to be higher than 70%. Two implications of the introduction of the two-dose DPT-immunization schedule are discussed, i.e. (a) the possibility of using it as the nucleus of a complete schedule including immunization against poliomyelitis, BCG, smallpox and measles, and (b) the consequences which the interval of 6 months might have on the epidemiological spread of B. pertussis infections.
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PMID:A two-dose schedule for immunization of infants using a more concentrated DPT-vaccine. 75 47

Various workers, including T. D. Stewart, claim that the aboriginal Americas were relatively disease-free because of the bering Strait cold-screen, eliminating many pathogens, and the paucity of zoonotic infections because of few domestic animals. Evidence of varying validity suggests that precontact Americns had their own strains of treponemic infections, bacillary and amoebic dysenteries, influenza and viral penumonia and other respiratory diseases, salmonellosis and perhaps other food poisoning, various arthritides, some endoparasites such as the ascarids, and several geographically circumscribed diseases such as the rickettsial verruca (Carrion's disease) and New World leishmaniasis and trypanosomiasis. Questionably aboriginal are tuberculosis and typhus. Accordingly, virtually all the "crowd-type" ecopathogenic diseases such as smallpox, yellow fever, typhoid, malaria, measles, pertussis, polio, etc., appear to have been absent from the New World, and were only brought in by White conquerors and their Black slaves. My hypothesis is that native American medical care systems--especially in the more culturally advanced areas--were sufficiently sophisticated to deal with native disease entities with reasonable competence. But native medical systems could not cope with the "crowd-type" disease imports that struck Indian and Eskimos as "virgin-field" populations. Reanalysis of native population losses through a genocidal combination of diease, war, slavery and attendant cultural disruption by Dobyns, Cook and others strongly suggest that traditiona estimates underplayed the death toll by a factor of the general order of ten. This would make for an immediately pre-contact Indian population of some 90-111 million instead of the tradition 8-11 million. Evidence is growing that Indians may have been no more susceptible to new pathogens that are other "virgin soil" populations, and thus their immune systems need not be considered less effective than those in other people. Present-day high mortality rates in Indians of both continents from infectious disease imports may be more socioeconomic than anything else.
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PMID:Aboriginal new world epidemiolgy and medical care, and the impact of Old World disease imports. 79 20

A three-year study of febrile convulsions in Oxford with comprehensive notification from general practice and hospitals showed a 3% risk for all children of suffering at least one febrile convulsion by the age of 5 years. Children were most at risk between 6 and 27 months, and febrile convulsions were most likely to be prolonged in children aged 9-15 months. The association between febrile convulsions and primary immunisations in the preceding 28 days was compared in case and control children, matched for age and sex. Results suggested that such association was a chance relationship with age. If association was direct, the febrile convulsion rates per 1000 immunisation doses were estimated as follows: diphtheria, pertussis, tetanus--0-09 per 1000; poliomyelitis--0-6 per 1000; and measles--0-9 per 1000. Hence if any of these vaccines had a secific causal relationship with febrile convulsions, these rates would probably have been much higher.
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PMID:Primary immunisation and febrile convulsions in Oxford 1972-5. 89 Mar 64

The possibility that some of the common childhood infections lead to unrecognized impairments of neurological function was examined in 43 820 Birmingham children whose intelligence was assessed in the 11-plus examination. Mean verbal reasoning scores were lower for children who had had measles or pertussis than for those who had had neither of these diseases. However, since attack rates and measured intelligence are related inversely to social class, the lower scores of children with measles and pertussis may be due to class differences which are not eliminated completely by standardization for maternal age and birth order. Mean scores were a little higher for children who had had rubella than for those who had not, and it is suggested that this difference may be due to more frequent reporting of the disease by the more intelligent mothers.
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PMID:Relationship between childhood infections and measured intelligence. 98 13

The effect, hazards and risk of vaccinations may be calculated by means of special formulas which determine the value for N, Q and D. The formula for N considers the question whether a vaccination is effective, necessary and valuable and may be recommended on epidemiological grounds. Q considers the individual risk (i. e. relation between total risk of unvaccinated and vaccinated persons) and D the yearly difference in risks between unvaccinated and vaccinated members of a community. If p stands for protection rate of a vaccination, t = time for which the vaccination effect is lasting, R = complications of disease under study in a community in which vaccinations against this disease are not in use and r = comparable complications of vaccination, the following formulas are applicable: (see article) A vaccination may be recommended if N and Q greater than 1 and the value for D is positiv. Application of these formulas to special vaccinations lead to the following conclusions: In case of BCG, measles and poliomyelitis (oral vaccination) the above mentioned values exceed at least 10(1)-10(2) (N), 4-5 (Q) or are highly positiv (D). These vaccinations-if performed correctly-are considered valuable and highly recommendable. Vaccination against pertussis is not recommendable beyond the second year of life. According to the present epidemiologic situation in Austria this vaccination is still rectified in children under 2 years. However, values for N, Q and D are near border-line and should be yearly evaluated. Smallpox vaccination in Europe is still recommendable. Similarly, continuous reevaluations are necessary due to low values of N, Q and D. On the other hand, vaccination against tetanus is available and vaccination against influenza may be recommended.
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PMID:[Mathematical methods to judge the efficiency of protective vaccinations (author's transl)]. 118 94

Widal test was done before and 15 days after the last dose of T.A.B. (33 Children) Diphtheria (13) Tetanus (16), Pertussis (7) and Measles (7) vaccinations. The tremendous rise of Widal agglutinin titers after T.A.B. vaccination could not foul up the results of the Widal test if we follow closely the suggested diagnostic Widal criterion combining a titer of 1/80 or more for "O" and 1/60 or more for one"H" agglutinin with the other "H" agglutinins at a lower titer.
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PMID:Study of the pattern of Widal test in infants and children. III. Effect of T.A.B., diphtheria tetanus, pertussis and measles vaccinations on the level of enteric fever agglutinins. 122 96

A retrospective study of 1984-89 records in the Department of Control and Surveillance of Diseases at the Directorate of Health Affairs in Al-Hassa, Saudi Arabia, aimed to determine the effect of vaccination coverage in the first year of life on the trend of target diseases of the expanded program if immunization (EPI), begun in February 1987, and to determine the effect this program had on vaccination coverage. From 1984-89, vaccination coverage of the first year of life increased significantly for BCG (88.6 vs. 97.8%); oral polio vaccine (86 vs. 96%); diphtheria, pertussis, and tetanus (DPT) vaccine (85.8 vs. 95.2%); and measles vaccine (72.6 vs. 89.2%) (p .01 for all vaccines). Average vaccination coverage per year in the first year of life against the EPI target diseases rose from 83-94.7% (p .01). The number of cases of pulmonary tuberculosis (TB) and measles decreased steadily during the same period (97-56 and 502-84, respectively). All the diphtheria cases occurred in 1985 (6 cases). There were no pertussis cases in 1985, 1987, or 1988. 14 pertussis cases occurred in 1984, 4 in 1986, and 2 in 1989. TB cases fell 42.3%,measles cases 83.3%, and pertussis 34.6%. Neither poliomyelitis nor neonatal tetanus afflicted any infants in Al-Hassa during the same period. A negative correlation existed between BCG, DPT, and measles vaccine and reported cases of respective diseases. It was significant for measles vaccine (p = .043). In fact, the number of reported cases of measles fell by 25 cases for every 1% improvement in measles vaccination coverage. Most infants (78.5-80.2%) were vaccinated against the EPI target diseases at primary health care centers or at Ministry of Health hospitals. The remaining 19.8-21.5% of infants received the EPI vaccines at health facilities of the Arabian American Oil Company, the National Guard, and the private sector. These findings suggested that implementation of the primary health care program, EPI, improved vaccination coverage and reduced the number of cases of EPI target diseases in Al-Hassa.
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PMID:Vaccination coverage before and after primary health care implementation and trend of target diseases in Al Hassa, Saudi Arabia. 129 51

Hepatitis B has long been recognized as hyperendemic among persons residing in the western Pacific. Effective control strategies have not been described. From December 1988 through October 1989, the Federated States of Micronesia (FSM) conducted a campaign to immunize children through age 6 years with three doses of hepatitis B (HB) vaccine. In addition, HB vaccination was incorporated into the routine immunization schedule for all children born in FSM, with the first dose given to newborns. Between December 1988 and October 1989, a total of 64,085 doses of HB vaccine were administered to the children. After the start of the campaign, the subject group was enlarged to include children through 15 years of age in the States of Yap and Kosrae. Fifty-nine percent of the enlarged group in all States received a complete series of HB vaccinations. During each client encounter, individual immunization records were examined and diphtheria-pertussis-tetanus, oral polio vaccine, and measles-mumps-rubella antigens were administered to children who were not adequately immunized. The annual immunization assessment for 1990 showed coverage improved significantly from previous years in every FSM State.
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PMID:The hepatitis B immunization campaign for children in the Federated States of Micronesia. 141 Feb 37

A total of 284 general practitioners (GPs), paediatricians and doctors of public vaccination centres (DPVC) were interviewed to investigate their willingness to immunize children with compulsory (diphtheria-tetanus, oral polio) and non-compulsory (measles, pertussis) vaccines in the presence of 19 different medical histories. We observed a reluctance to immunize in the case of false contraindications, a lack of information mainly about non-compulsory immunizations, and doubts about the real contraindications to polio, measles and pertussis vaccines. The frequency of correct answers to the question posed was significantly higher in the group with less than 20 years of experience, and the DPVCs proved better informed about immunization. However, the crucial role played by the GPs and paediatricians' advice can prejudice the correct use of active immunization.
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PMID:Compulsory and non-compulsory immunizations: contraindications perceived by medical practitioners. 144 29

In tropical countries, concomitant infections are a continuous problem. In the Rufiji Delta, an area of Tanzania that is holoendemic for malaria, there were outbreaks of influenza A, measles, and pertussis in 1986 and 1987. Significantly lower parasitic prevalences and mean densities of malaria parasites were found in children up to nine years of age who had measles or influenza than in asymptomatic control children. In contrast, children with pertussis had a higher prevalence and mean density than controls. The clinical courses of measles, influenza, or pertussis infections did not appear to be significantly affected by concomitant malaria infections. The reasons for the suppression of Plasmodium falciparum parasitemia during these viral infections are unclear. This effect could not be explained by the presence of fever.
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PMID:Suppression of Plasmodium falciparum infections during concomitant measles or influenza but not during pertussis. 144 8


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