Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0043167 (pertussis)
 19,595 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A case of an 11-month-old black male with pertussis syndrome is described. He manifested a lymphocytic leukemoid reaction characterized by marked lymphocytosis and the presence of lymphoblasts in his circulation. A bone marrow examination did not reveal any evidence of acute leukemia. Electron microscopic examination of peripheral blood lymphoid cells revealed the presence of lymphoblasts and immature plasma cells, as well as unusual intramitochondrial and intranuclear bodies. The significance of these structures is discussed.
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PMID:Ultrastructure of lymphocytes in a case of pertussis syndrome. 709 83

A 73-days old infant of 34 weeks' gestation was hospitalized with a co-infection of respiratory syncytial virus (RSV) and Bordetella pertussis (BP). She required invasive ventilation for 9 days in the context of malignant pertussis with persistent hypoxemia and hypercapnia secondary to a leukemoid reaction. Despite an increase of white blood cell (WBC) count up to 70 G/L and ensuing pulmonary hypertension, no hemodynamic compromise occurred. Without clear indication for leukapheresis nor exchange transfusion, an off-label treatment with hydroxyurea was given for 5 days with gradual decrease of WBC count, without any complication and hospital discharge on day 29. To our knowledge, no effective therapy for malignant pertussis has been described in the literature and complications are frequent with leukoreduction procedures. We discuss an alternative to invasive procedures in young infants to fulfill the need to decrease rapidly leukocyte counts in a leukemoid reaction associated with Bordetella pertussis infection. To our knowledge, hydroxyurea has never been used in malignant pertussis but is a well-known medication for oncologic and hematologic diseases such as acute myeloid leukemia or sickle cell anemia. Its effects in this setting are not well understood but the positive outcome in our patient supports the need for further studies.
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PMID:Leukemoid Reaction in Infant Pertussis: Is There a Place for Hydroxyurea? A Case Report. 3035 38