Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0043167 (pertussis)
 19,595 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Epidemic patterns of 12 infectious diseases based on the data derived from the surveillance system of infectious diseases in Japan are analyzed. Weekly numbers of patients per one monitor station (general clinics and hospitals) are calculated by prefecture. Based on these data, the patterns of epidemic are classified into five categories: Category 1, nationwide outbreak of short duration (rotavirus enteritis, hand-foot-mouth disease and herpangina); Category 2, nationwide outbreak of long duration (varicella); Category 3, concurrent outbreaks in several districts (rubella and erythema infectiosum); Category 4, epidemic of long duration in several prefectures at different times (measles, mumps, pertussis, streptococcal infection and atypical pneumonia); Category 5, unclear epidemic pattern (exanthema subitum).
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PMID:Epidemic patterns of infectious diseases from the results of the surveillance of infectious diseases in Japan. 336 59

Three children had striking localization of varicella lesions to skin overlying a diphtheria-pertussis-tetanus toxoid (DPT) immunization injection site, a facial abrasion, and a sunburn of the trunk, respectively. Presumably, during the viremic stage of varicella, the virus passed from damaged blood vessels into the skin. A disabling myalgia in the thigh at the DPT site in one child may also have been the result of localization of the varicella virus in the muscle during the inapparent viremic stage. This suggests that an injection given during an occult viremia could trigger an unexpected reaction at the site.
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PMID:Immunization, abrasion, and sunburn as localizing factors in chicken pox. 365 31

A retrospective analysis of absolute numbers in 802 white blood counts and 396 sedimentation rates of 407 children, admitted between 1973-78, with 9 "classic" infections was done and evaluated for diagnostic usefulness. As diagnostic meaningful it was found: Lymphocytosis in pertussis; lymphocytopenia and slight increased sedimentation rate in measles; nothing particular in mumps; slight increased sedimentation rate in chicken pox; increase in mononuclear cells, particularly atypical lymphocytes and sedimentation rate in infectious mononucleosis; leucocytopenia caused by neutrocytopenia and lymphocytopenia in exanthema subitum (roseola infantum); increased sedimentation rate in scarlet fever; lymphocytopenia and a high sedimentation rate in mycoplasma-pneumonia; leucocytopenia with lymphocytopenia in rubella.
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PMID:[Leucocyte number, differential count and sedimentation rate in 9 "classic" childhood infections. (author's transl)]. 719 42

The current status of immunization practice and recommendations for adolescents is reviewed. Vaccines for diptheria, tetanus, pertussis, measles, mumps and rubella are discussed in detail and vaccines for influenza, the pneumococci, meningococci, varicella, rabies, smallpox and tuberculosis briefly reviewed. Special attention is paid to those aspects of each vaccine and disease particularly appropriate to the adolescent age period.
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PMID:Immunization for adolescents. 726 28

A recent analysis demonstrated a change in incidence approaching 100% for diseases against which we routinely immunize in the United States. At present, measles, mumps, rubella, invasive Haemophilus disease, poliomyelitis, diphtheria and tetanus are well-controlled but not eliminated. Diseases that now pose special problems include pertussis, hepatitis A and B and varicella. The incidence of pertussis surged in 1994, possibly in part because of waning immunity in the immunized population. Acellular pertussis vaccines are available for booster doses in children but are not now recommended for adults. Licensure of acellular pertussis vaccines for primary immunization of infants is eagerly awaited. Recombinant hepatitis B vaccine has been licensed for more than 10 years but there has been little change in disease incidence in the United States. Routine immunization of infants is now recommended but concerns exist about cost and persistence of immunity into adolescence. Inactivated hepatitis A vaccines appear to be highly effective in preventing clinical hepatitis and controlling epidemics. Potential target populations include military personnel, day-care attendees and travelers. Hepatitis A vaccine may be recommended for all children after approval by the United States Food and Drug Administration and if a combination vaccine becomes available. A live, attenuated varicella vaccine developed in 1974 and unlicensed in the United States is safe and highly effective in preventing varicella in healthy and immunocompromised populations. It also appears to reduce subsequent development of herpes zoster. Vaccines against pneumococci (conjugate vaccine), respiratory syncytial virus, rotavirus, tuberculosis and human immunodeficiency virus are needed. Research and technology to develop these vaccines must be developed, and efficient delivery mechanisms must be created and implemented.
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PMID:Present and future challenges of immunizations on the health of our patients. 763 35

The development of insulin-dependent diabetes mellitus is thought to be related to environmental trigger factors acting upon a background of genetic predisposition to the disease. Viral infections, toxins, and dietary factors are being considered as trigger factors. The authors studied the relationship of the development of diabetes from birth up to 15 years of age to the type of feeding in infancy, childhood infections, and vaccination among 55 patients attending Endocrinology Clinics of the Ethio-Swedish Children's and Tikur Anbessa Hospitals over the period January 1990 to December 1991. 74 unaffected siblings and 107 unrelated individuals were included as controls. No significant difference was found in relation to type of feeding up to the ages of three, six, and twelve months or older between patients and unaffected siblings. Histories of measles, chicken pox, and whooping cough were equally distributed between the two groups. The introduction of bottle-feeding, however, was significantly more frequent among unrelated controls at three months and six months of age. The use of cow's milk and other formulas in bottle-feeding showed a significant negative association with the development of diabetes. An history of vaccination against tuberculosis, measles, diphtheria, pertussis, tetanus, and polio was significantly more common among unrelated controls than diabetics. There was no significant difference in family history of diabetes in first degree relatives, parental education, and level of income between diabetics and unrelated controls. The authors suggest that more extensive studies are warranted.
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PMID:The relation of early nutrition, infections and socio-economic factors to the development of childhood diabetes. 783 52

Infection remains a major cause of morbidity and mortality in transplant patients. Many infections, however, can be successfully prevented by immunization. This presentation reviews the problems associated with, and the questions that arise concerning the use of routine pediatric vaccines, such as diphtheria-pertussis-tetanus (DPT) and measles-mumps-rubella (MMR). It also reviews the use of special vaccines such as hepatitis B, pneumococcal, and influenza vaccines in transplant patients. Data concerning the use of two experimental, live-attenuated virus vaccines, against cytomegalovirus (CMV) and varicella, are discussed. The live-attenuated varicella vaccine can be predicted to decrease the morbidity and mortality of varicella-zoster virus infection in transplant patients. It has already been given successfully to immunocompromised children and is highly effective in the prevention of varicella.
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PMID:Immunizations for pediatric transplant patients. 824 77

By 1995, measles, mumps, and rubella were eliminated from Finland, acellular vaccines for pertussis were showing great promise, and the global eradication of poliomyelitis by the year 2000 looked possible. The meningococcus was replacing Haemophilus influenzae type b as the main cause of childhood meningitis, and 75 countries were vaccinating their children against hepatitis B. The United States recommended varicella vaccination for children, effective vaccines were available for hepatitis A, and new vaccines for rotavirus and cholera were being tested; malaria and HIV offer a continuing challenge.
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PMID:Update on immunization. 868 May 9

Rotavirus infection produces a serious health burden in the United States, causing an estimated > 100,000 hospitalizations and > 100 deaths annually. This health burden is comparable to that for measles, pertussis, mumps, and varicella before vaccines for these diseases were routinely given to children. Rotavirus vaccines have the potential to significantly reduce a serious public health problem in the United States. However, while development and licensure of vaccines is a major breakthrough, it represents only the first step in disease prevention. Vaccines must be recommended by major immunization advisory committees, financed in both the public and private sectors, and successfully integrated into the existing vaccination schedule. Vaccines must reach all targeted children, and monitoring systems must be established or adapted to better determine vaccine safety and disease impact. Reevaluation of disease prevention strategies must be ongoing and fueled by new information on safety and disease reduction.
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PMID:Rotavirus vaccines--from licensure to disease reduction. 875 1

Present strategies for vaccinations are based on new vaccines of classical (hepatitis A, influenza, varicella) or modern (hemophilus, hepatitis B) conceptions. They include variable schemes according to the vaccinal doses (hepatitis A, B, diphteria) or the number of injections (hepatitis A, B, rabies). Their goals are eradication (Measles, Mumps, Rubella), or immune maintenance by boosters (hepatitis A, poliomyelitis, tetanus). They introduce associated vaccines in the vaccinal calendar (diphteria, tetanus, poliomyelitis, pertussis, hemophilus b and hepatitis B). They enlarged the area of targeted vaccinations for at risk-professions or pathologies and for travellers.
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PMID:[New strategies of vaccination in France in 1995]. 888 Nov 99


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