Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0043167 (
pertussis
)
19,595
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
There has been a noticeable increase in the incidence of
pertussis
in West Germany over the last decade. Since the availability of adequate bacteriological diagnosis a much broader clinical spectrum can be attributed to infections with B.
pertussis
. Three patients with an unusual clinical presentation of
pertussis
are presented. A three month old infant presented with severe apneic spells without cough as the sole clinical symptoms of the infection. B.
pertussis
was isolated in the nasopharyngeal swab. A nine month old premature infant with
bronchopulmonary dysplasia
after long time intubation and artificial ventilation presented with apneic spells, pulmonary and cardiac decompensation and required ventilatory support. The diagnosis was suggested by a massive leucocytosis with lymphocytosis. The diagnosis on the patient was established by serologic methods. Adult contacts of this patient developed longstanding cough and clinical signs of
pertussis
. The diagnosis of
pertussis
in these persons was established by nasopharyngeal culture. The third patient with trisomy 21 and a corrected AV canal suffered from nonspecific cough and gradually developed signs of congestive heart failure with pneumonia. B.
pertussis
was isolated from the nasopharynx. This patient showed neither the typical paroxysmal coughing spells nor disclosed the typical lymphocytosis in his white blood count. Microbiological investigations of patients with symptoms of respiratory tract infections should include the isolation of B.
pertussis
. Thus, additional cases of
pertussis
not suspected on the basis of their initial clinical presentation will be detected.
...
PMID:[Pertussis--an illness with typical clinical symptoms?]. 143 95
