Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0043167 (
pertussis
)
19,595
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
C4BP
(C4b-binding protein) is a high-molecular-weight plasma protein that inhibits the classical pathway of complement activation. Recent experiments have demonstrated that
C4BP
binds to many strains of the gram-positive bacterium Streptococcus pyogenes, a major respiratory tract pathogen. Binding to S. pyogenes was shown to be due to members of the M protein family, a group of surface proteins important for virulence. Here we report that human
C4BP
also binds to all clinical isolates of the gram-negative bacterium Bordetella
pertussis
, the etiologic agent of whooping cough. In addition, binding of
C4BP
was demonstrated for other Bordetella species that can cause disease in humans. Characterization of different B.
pertussis
mutants showed that the binding of
C4BP
is strongly dependent on the expression of the cell surface protein filamentous hemagglutinin, a well-known virulence factor. Inhibition experiments suggested that B.
pertussis
and S. pyogenes bind to the same region in
C4BP
. The finding that B.
pertussis
and S. pyogenes both have the ability to bind human
C4BP
suggests that these two unrelated respiratory tract pathogens may use a common mechanism during the establishment of an infection.
...
PMID:Bordetella pertussis binds the human complement regulator C4BP: role of filamentous hemagglutinin. 928 30
