Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0043167 (pertussis)
 19,595 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effect of an i.p. injection of Bordetella pertussis on the primary humoral immune response in mice to the thymus-independent antigen SIII has been studied. Suppression of the antibody response occurred when pertussis cells were injected at the same time as an optimal immunizing dose of SIII. In contrast, the antibody response to high doses of SIII was enhanced by B. pertussis. When SIII alone was injected, only 19S antibody was detected. However, when B. pertussis was administered with either optimal or high doses of SIII, 7S as well as 19S antibody against SIII was produced.
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PMID:The effect of Bordetella pertussis on the antibody response in mice to type III pneumococcal polysaccharide. 0 10

Thymus of (C57Bl/6 x DBA/2) F1 mice was examined histologically, histochemically and ultrastructurally, seven days after intravenous injection of BCG, pertussis vaccine, lipopolysaccharide or human gamma globulin, or intraperitoneal injection of complete or incomplete Freund's adjuvants or of phytohemagglutinin. Only BCG induced a marked increase of the secretory activity of the thymic epithelium at all histological sites (cortex, corticomedullary junction and medullar). Only with this adjuvant was the epithelial hyperplasia associated with marked mitotic activity and high percentage of cells with cytoplasmic pyroninophilia among cortical lymphoid cells. The other substances tested produced different changes in the thymic epithelial cells according to the histologic zones. These results suggest that the epithelial cells of the cortex, the corticomedullary junction and the medulla respond differently to the agents tested and that the action of these substances upon thymus-dependent lymphoid cells may be indirect perhaps involving factors secreted by the epithelial cells.
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PMID:The effects of certain immunity systemic advuvants, PHA, and human gamma globulin on the thymic cortex of mice: a light and electron microscope study. 6 71

The postnatal development of resistance against infection was monitored by the treatment of juvenile mice with a virulent strain of Listeria monocytogenes. It could be shown that until day 10 after birth, young mice succumbed to an infection with even minimal doses of bacteria. Between day 15 and 30, the resistance against infection gradually increases until the rather constant level of grown-up animals is reached (Fig. 1). Juvenile mice that survive the primary infection are able to build up a state of immunity, which is rather similar to that of grown-up mice (Fig 3). Immunity against L. monocytogenes is mainly expressed by a functionally active T-cell system; the maturity of these cells in 15 days old mice could be demonstrated by the transfer of cells to "nude"-mice, which lack a thymus (Fig. 4). A significant increase of the non-specific resistance can be achieved even in 10 days old mice by the injection of adjuvants like pertussis organisms or endotoxin of Salmonella typhi some days before infection (Fig. 5, Fig. 6). Our findings suggest that a deficiency of functionally active macrophages is responsible for the insufficient resistance against infection with L. monocytogenes in young mice.
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PMID:Postnatal development of resistance against infection in an experimental model. 10 82

The histamine-sensitizing factor (HSF) of Bordetella pertussis was isolated in a highly purified form. In addition to inducing profound sensitization to histamine, it also caused a significant lymphocytosis and produced an enhancement of reaginic antibody production in animals upon immunization with antigen. Biologically active doses of HSF produced significant pathological changes in mice including congestion and edema of the lung and a marked depletion of cells in the thymus, white pulp of the spleen, and lymph nodes. The lymphocytosis and histological changes in the lungs and lymphoid organs were observed in different strains of mice injected with HSF (even those that are resistant to its histamine-sensitizing effects). Heating HSF at 80 degrees C for 30 min, a treatment that destroys histamine sensitizing and lymphocytosis promoting activities, completely abolishes the ability to induce the changes observed in the lungs and lymphoid organs.
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PMID:Histopathological changes in mice treated with extracts of the histamine-sensitizing factor of Bordetella pertussis. 19

The purified lymphocytosis promoting factor (LPF) from Bordetella pertussis was found to be a potent mitogen for peripheral blood lymphocytes (PBL) from normal adults as well as for cord blood lymphocytes. Proliferation occurred in autologous plasma or fetal calf serum, regardless of previous exposure to pertussis infection or immunization. Only one adult human serum, from a physician constantly working with B. pertussis, inhibited the mitogenic response to LPF and this serum was shown to contain precipitating antibody against LPF. The proliferative effect of LPF was characteristic of a "nonspecific" mitogen and not of antigen stimulation of sensitized cells.LPF, phytohemagglutinin, and concanavalin A were approximately equal in potency although variation occurred depending upon the cell donor. Experiments with lymphocyte subpopulations obtained by rosetting techniques employing sheep erythrocytes, mouse erythrocytes, and sheep erythrocytes coated with antibody and complement suggested the requirement of a multicellular system for LPF mitogencity.PBL from most patients with chronic lymphatic leukemia and lymphosarcoma cell leukemia were even less responsive to LPF than to phytohemagglutinin, whereas PBL from patients with lymphosarcoma usually responded to both mitogens. It can be inferred from the results of experiments with both normal and leukemic cells that LPF, which is a murine thymus-derived (T)-cell mitogen, is also a T-cell mitogen for human PBL. The exact cell requirement and mode of action, however, are as yet unknown.
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PMID:The mitogenic effect of the lymphocytosis promoting factor from Bordetella pertussis on human lymphocytes. 19 21

The leukocytosis and lymphocytosis-promoting factor (LPF) of Bordetella pertussis has been isolated in apparently pure form. LPF is a protein essentially free of lipid and carbohydrate with an estimated molecular weight of 67,000-73,600 daltons. Purified LPF induced both histamine sensitization and refractoriness to epinephrine-induced hyperglycemia and was a murine thymus-derived (T-) cell mitogen. Adenyl cyclase activity also appeared to be associated with LPF.
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PMID:Lymphocytosis-promoting factor of Bordetella pertussis: isolation, characterization, and biological activity. 19 75

Experiments were conducted on mice, strain NIH, line HSFS/N, immunized with pertussis vaccine. Determination of thymocyte pool proved to be a more sensitive method of detection of the stress effect of the vaccine than determination of the thymus weight. The test can be used for the elaboration of the method of assessment of the toxicity of pertussis preparations.
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PMID:[Methods of determination of toxicity of pertussis vaccine. 1. Change in the weight of the thymus gland and the spleen in mice after administration of pertussis vaccine]. 30 51

Carrageenan, a known macrophage toxin and immunosuppressive agent, has been studied for its effect on antibody responses following single doses or multiple daily increasing doses of sheep red blood cells (SRBC) injected intraperitoneally (i.p.) in male CBA strain mice. Results showed that lambda carrageenan administered prior to a single i.p. injection of SRBC markedly suppressed both the IgM and IgG responses. However, when carrageenan-treated mice were injected with multiple daily increasing amounts of SRCB antigen, high titers of specific antibody activities were produced in serum while only IgM plaque-forming cells (PFC) were detected in the spleens up to 8 weeks later. Higher serum titers were obtained if Bordetella pertussis vaccine was administered i.p. shortly before the first antigen dose was injected in the carrageenan-treated mice. Direct PFC (IgM) but not indirect PFC (IgG) were detected in suspensions of spleen cells late in the response of these mice. Such treatment may provide a useful method for raising high titers of cytotoxic IgM antibody to other T-dependent antigens. Evidence is presented to show that pertussis vaccine--a known potentiator of the IgG response--does not reverse the inhibitory effects of carrageenan. Results also provide evidence for the requirement of functional macrophages in the induction of helper-cell activity for the thymus dependent IgG response in vivo.
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PMID:A method for the induction of a prolonged elevated IgM response without the formation of IgG antibody, by injecting carrageenan-treated mice with multiple doses of sheep erythrocytes. 31 64

The authors studied the developmental mechanism of postvaccinal resistanceof mice (C57BL/6J and CC57Br) to the intracerebral infection with the virulent B. pertussis culture. A model of syngenous transfer of various cells of the immunized donors (peritoneal cells, cells of neuroglia, the spleen, thymus and the lymph nodes) was used. Marked adoptive immunity proved to originate in the use of peritoneal cells which provided protection of 57--100% of the recipients. Preliminary inactivation of the vaccine by heating was accompanied by the loss of the cell capacity of the immunized donors to cause adoptive immunity in the recipients.
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PMID:[Cellular immunity in mice immunized with pertussis vaccine]. 91 25

In this work we demonstrate a suppressive activity on the induction of experimental allergic encephalomyelitis (EAE) in Lewis rats, transferable to syngeneic animals, challenged with encephalitogenic mixture (myelin basic protein, complete Freud's adjuvant plus Bordetella pertussis organisms) 24 h later. This activity is probably effected by T cells and not by (an) inhibitory serum factor(s). The induction of this specific protection could be due to the penetration of the myelin basic protein antigen into the thymus where we first found suppressive cells. From the thymus, suppressor cells could then emigrate to spleen (on day 15) and to nondraining lymph nodes (on day 17). In the course of normal EAE in Lewis rats and especially at the time of self cure, this suppression is not demonstrated, but possible.
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PMID:Evidence for suppressor cells in Lewis rats' experimental allergic encephalomyelitis. 92 33


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