Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0042963 (
vomiting
)
31,883
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Hereditary fructose intolerance (HFI) is an autosomal recessive disorder caused by mutation in the
ALDOB
gene, which leads to aldolase B deficiency. Fructose ingestion results in accumulation of substrates fructose 1-phosphate and fructose 1,6-biphosphate, leading to impairment of glycolytic and gluconeogenic pathways
(1,2)
. Patients with HFI typically present with
vomiting
, hypoglycemia, hepatomegaly, acute liver failure, renal tubular dysfunction and failure to thrive
(1,2)
.
...
PMID:Sucrose Toxicity in Infants. 3327 39
