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Query: UMLS:C0042963 (vomiting)
 31,883 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Midtrimester abortion was induced in 94 of 100 patients at 16 to 24 weeks' gestation by the extra-amniotic administration of 1170 microng of prostaglandin F2alpha (PGF2alpha) every 10 minutes. The number of prostaglandin doses varied from 16 to 24 depending on the patient's response to the prostaglandin. The median abortion time was 10.0 hours, and 82.0% of the patients aborted within 24 hours. Overall, 68.0% of the patients failed to expel the placenta within one hour of abortion of the fetus. Vomiting and diarrhea occurred among 42.0 and 17.0% of the patients, respectively. Compared with the intra-amniotic administration of a single 50 mg dose of PGF2alpha, the extra-amniotic procedure was associated with similar side effect rates, a higher rate of incomplete abortion, and a significantly shorter abortion time.
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PMID:Repeated extra-amniotic administration of prostaglandin F2alpha for midtrimester abortion. 1 92

Women undergoing abortion by intraamniotic prostaglandin F2alpha were randomized to receive either prochlorperazine edisylate 10mg, hydroxyzine hydrochloride 100mg, or a placebo every four hours by intramuscular injection in a double-blind fashion. Vomiting was significantly more frequent in the placebo-treated group [0.2 +/- 1.5 SD episodes per patient, n=21] than in the groups treated with prochlorperazine [1.2 +/- 0.5 episodes per patient, n=21] or hydroxyzine [0.3 +/- 0.8 episodes per patient, n=19]. The mean number of merperidine injections in the antiemetic-treated groups was lower than in the control group, but this effect was not statistically significant. There was no significant difference between the treated and the control groups in the interval from prostaglandin treatment to abortion.
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PMID:A controlled trial of antiemetics in abortion by PGF2alpha and laminaria. 2 33

A clinical trial comparing 2 vaginal dose schedules of 15(S)15-methyl prostaglandin F2alpha (PGF2alpha) methyl ester (4 or 6 mg) for preoperative dilatation is described. The trial included 28 patients at 8-12 weeks gestation. Vaginal pessaries containing either 1.0 mg (15 patients) or 1.5 mg (13 patients) of the prostaglandin analogue were administered every 3 hours (maximum, 4 doses). The success rates for the 2 groups were 93% and 10% respectively. A 96.4% overall success rate is comparable to that achieved in other studies. 60% of the patients aborted before the planned vacuum aspiration. Minor side effects, primarily vomiting and diarrhea, occurred in approximately 80% of the cases and were more prominent with the higher dose pessary. Since this higher dosage produced an unacceptably high occurrence of gastrointestinal side effects, the lower dosage of 4 mg is preferable. It is concluded that vaginal administration of 15(S)15-methyl PGF2alpha methyl ester is highly effective for preoperative dilatation of the cervix before suction curettage abortion.
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PMID:Preoperative cervical dilatation with 15(S)15-methyl PGF2alpha methyl ester pessaries. 2 76

The results of a comparative study of the efficacy and acceptability of 15(S)15-methyl prostaglandin F2alpha (15-Me-PGF2alpha) administered as a single i.m. injection or vaginal suppositories (15-Me-PGF2alpha methyl ester) every 3rd hr for termination of very early human pregnancy is reported. The amenorrhoic period varied from 37 to 60 days. Group I (30 cases) received 0.6 mg as a single i.m. injection without any pretreatment. Retrospectively 24 of the 30 women were in fact pregnant and 22 of them aborted. Group II received suppositories (1.0 or 1.5 mg per suppository). In this group all women were pregnant and they all aborted. Symptoms such as pain, bleeding, vomiting and diarrhea started in general earlier in the i.m. group and they were more marked. In the present series the efficacy and acceptability were highest for the vaginal route of administration.
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PMID:15(S)15-methyl prostaglandin F2alpha for termination of very early human pregnancy. A comparative study of a single intramuscular injection and vaginal suppositories. 33 83

This article discusses the parallel results of interruption of advanced pregnancy (14-20 weeks) with Prostaglandin F2alpha (PGF2alpha) and a 20% NaCl solution. 40 mg of PGF2a was administered intraamniotically with another 20 mg administered if abortion did not occur within 24 hours. The 20% NaCl solution was given intraamniotically and without aspiration of the fetal liquid in a quantity of 200 ml in some of the patients. Likewise, with the 20% NaCl solution, an intravenous (IV) infusion of syntocyne was administered drop by drop (average dosage 0.19 Ij/minute). This procedure was carried out until abortion of the fetus took place in 1/2 of the patients, while in the second 1/2 it was performed until abortion of the placenta. The abortion was considered a failure it it did not take place within 48 hours (with administration of both agents). In 67 cases, abortion was successful with PGF2alpha. In 4 patients it failed and was terminated by induction with syntocyne. However the 20% NaCl solution and IV syntocyne infusion resulted in abortion in 71 patients. The following number of incomplete abortions was registered: 20.9% with PGF2alpha and 16.9% with hypertonic NaCl solution. The latency period was 22.21 hours with PGF2alpha and 21 hours with 20% NaCl solution. Side effects (vomiting, diarrhea, fever) were higher with the PGF2alpha. 2 cases of diffuse peritonitis were registered, each due to each one of the agents, and both patients recovered. Better results with the 20% NaCl were due to the parallel IV infusion of syntocyne. However, caution must be exercised as this utertonic may cause genital organ lesions.
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PMID:[Comparison of the results of interruption of advanced pregnancy using prostaglandin F2-alpha and a NaCl solution]. 50 72

Different groups of dogs were given prostaglandin F2alpha IM. The dosage range was between 0.022 and 0.555 mg/kg of body weight. Defecation, including contents from the cranial portion of the large intestine, occurred in 40% to 100% of the dogs within 3.16 to 12.5 minutes after injection depending on dosage administered. Defecation (83.3% of dogs), without vomition, occurred in dogs given a dosage of 0.111 mg/kg. Emesis (87.5% of dogs) and defecation (75.0% of dogs) were observed in dogs given a dosage of greater than or equal to 0.444 mg/kg. Emesis occurred in 1.6 to 2.6 minutes after defecation in dogs given more than 0.444 mg/kg. Latency for emesis response varied between 3.2 and 11.5 minutes. The effect of the drug lasted approximately 15 minutes, with most dogs showing a single episode of defecation or vomition (or both). Besides a marked increase in respiratory rate, side effects were minor. Seemingly, prostaglandin-F2alpha may become the preferred drug for the clinical inducement of vomition and defecation in dogs.
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PMID:Induction of intestinal evacuation or vomition (or both) in the dog by prostaglandin F2alpha injection: clinical potential. 52 91

250 mcg 15(S)-15-methyl-prostaglandin F2alpha (PGF2alpha) was administered intramuscularly every 3 hours to 10 women between 12-18 weeks gestation. All aborted within 20 hours with a mean induction-abortion interval of 14.1 hours. 8 patients experienced side effects such as nausea, vomiting, and diarrhea. (author's modified)
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PMID:[Induced abortion with intramuscular administration of 15(S)-15methyl-prostaglandin F 2 alpha]. 56 Jul 70

Intramuscular injections of 15(S)-15-methyl prostaglandin F2alpha (15-Me-PGF2alpha) induced abortion in 38 patients who had failed to abort with other techniques, such as intra-amniotic instillation of saline or PGF2alpha and intravaginal insertion of prostaglandin-impragnated Silastic devices. The intramuscular injections of 15-Me-PGF2alpha were initiated when the original abortion techniques, even when augmented by intravenous oxytocin, failed to produce expulsion of the fetus. The dose schedule was 250 microgram or 500 microgram every 2 to 4 hours, and the concomitant intravenous oxytocin was continued at a rate of 167 mU/minute. Of the 38 patients, 26 aborted with two or fewer injections of 15-Me-PGF2alpha, and 30 patients required only 1 mg of the drug to expel the fetus successfully. The mean time from the first injection of 15-Me-PGF2alpha to the expulsion of the fetus was 5.25 hours; one-half of the patients aborted in less than 4 hours. The placenta was expelled spontaneously in 15 patients, removed manually from the vagina in 18, and removed by sponge forceps in 3. Two abortions were incomplete and surgical intervention was required. Twenty-eight patients (74%) experienced gastrointestinal disturbances, chiefly vomiting and diarrhea. Intramuscular administration of 15-Me-PGF2alpha eliminates the need for repeated amniocentesis, and the dose may be adjusted to meet the precise requirements of the clinical situation.
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PMID:The effects of intramuscular injections of 15(S)-15-methyl prostaglandin F2alpha in failed abortions. 56 11

Hormonal changes associated with the use of 15(S)-15-methyl prostaglandin F2alpha in a Silastic device as an abortifacient were evaluated during very early first-trimester pregnancy. Five of six patients aborted completely with drug alone. Measurement of plasma samples demonstrated rapid drug absorption with apparent effective concentrations of 600 to 3000 pg/ml but without a pattern of sustained release and absorption. Routine serial determination of both serum chorionic gonadotropin (hCG) and beta-subunit hCG were used to assess the efficacy of treatment. Although more sensitive, beta-hCG measurement offered no advantage clinically over the standard hCG assay. Plasma progesterone values also reflected success or failure of the technique. Vomiting and diarrhea continue to be problems associated with the use of these compounds. The Silastic device may be the forerunner of a self-administered early abortifacient. Continued efforts are necessary to elucidate mechanisms of action and to find an analog specific for myometrial stimulation.
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PMID:Abortion of early pregnancy on an outpatient basis using Silastic 15(S)-15-methyl prostaglandin F2alpha vaginal devices. 56 13

18 women ranging in age from 17-45 years receiving intramuscular injections of 250 mcg of 15-methyl-prostaglandin F2alpha (15-methyl-PGF2alpha) averaged 17 hours +or- 7 hours to delivery. Injections were repeated after 2 hours and every 5 hours thereafter. The cumulative abortion rate for the substance was intermediate between the very favorable results obtained using intraamniotic applications of E2 prostaglandins on the 1 hand and the somewhat unfavorable results with intraamniotic and retroamniotic applications of F2 alpha on the other hand. A comparison of side effects of intramuscular injection of 15-methyl-PGF2alpha with those of PGF2alpha injected intraamniotically or retroamniotically indicates that the occurrence of vomiting was slightly greater with it but the occurrence of diarrhea was almost the same. The dynamics of labor with 15-methyl PG were found to be similar to labor after injection of PGs intraamniotically and retroamniotically. The results suggest that 15-methyl-PGF2alpha is a safe and practical substance for inducing labor between the 10th and 20th week of pregnancy.
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PMID:[The effect of 15-methyl-prostaglandin F2 alpha administered intramuscularly to induce abortion in the first half of pregnancy (proceedings)]. 57 12


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