Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042963 (vomiting)
 31,883 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A young female anorexia nervosa patient reported who was undigested with food, weight dropped to half of the normal standard. She manifested not only episodic bulimia, impulsive self-injury, suicidal attempt, and obvious depressive emotion; but also self-provoked-vomiting, wandering, stealing and lying. The course of disease lasted already three years, she got 37 points on Hamilton Depressive Scale. Positive DST and normal EEG were exhibited in lab tests. The patient was improved after comprehensive therapy for about 5 months and then discharged. The recent literatures were reviewed on epidemiology, etiology, clinic features, therapy, prognosis and its relationship with depression.
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PMID:[Anorexia nervosa with bulimia and self-provoked-vomiting (a case report)]. 159 55

The purpose of this study was to identify variables useful for predicting a positive response to the tricyclic antidepressant desipramine, amongst bulimic subjects. Using a randomized double-blind cross-over design, 24 normal weight bulimics completed a 15-week protocol in which they received either desipramine (150 mg/day) for six weeks, no drug for three weeks, followed by placebo for six weeks, or the reverse sequence. At weeks 0, 2, 4, 6, 9, 11, 13, and 15, each subject was assessed using the EDI, SCL-90, POMS and binge records. The DST, Diagnostic Interview Schedule (DIS), and a personal and family medical-psychiatric history questionnaire were administered at initial assessment, while plasma desipramine levels were obtained at weeks 4 and 13. Responders were defined in terms of both binge frequency reduction, and decrease in depressive symptoms. In the sample of 24 subjects, desipramine was significantly more effective than placebo in reducing the frequency of weekly binging and vomiting, as well as causing a reduction in the fatigue scale of the POMS. No significant effect of the drug was obtained on the EDI or the SCL-90. In terms of reduction in binge frequency, seven responders were identified; another seven were found to be borderline responders, while 10 were labeled as non-responders. The three groups did not differ in terms of their initial scores on the SCL-90, POMS, DST, DIS results, or psychological subscales of the EDI. However, responders were found to have lower EDI bulimia subscale scores, but a higher frequency of purging episodes than were non-responders. Eight patients were identified as borderline responders with respect to depressive symptoms.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Bulimia: independence of antibulimic and antidepressant properties of desipramine. 264 70