Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042963 (vomiting)
 31,883 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A successful case undergoing the ECA-PCA bypass operation with the use of an interposition saphenous venous graft for vertebrobasilar progressing stroke was reported and details of the operative techniques were described. A 40-year-old man was admitted because of confused mental state following sudden onset of headache, vomiting, vertigo, and ataxic gait. Neurological examinations revealed he was confused and restless, and left-sided Weber's syndrome, bulbar palsy and dysphasia were noticed. CT scan showed multiple small low density areas with no enhancement scattering in both occipital lobes and cerebellar hemispheres. Angiographical studies showed that the left vertebral artery was occluded at the vertebrobasilar junction and the right vertebral artery stenosed up to 90% or more at the branching site of the PICA. There was no visualization of the vertebrobasilar system through the right posterior communicating artery. The left posterior communicating artery was not examined. The patient was treated with Urokinase amounting to 740,000 units for ten days. Thirteen days later, however, he became progressively drowsy and he became unable to speak and swallow. Quadriparesis also appeared. Progressive deterioration of these brain stem ischemic symptoms was assumed to originate from critically lowered perfusion of the vertebrobasilar circulation. Therefore, the ECA-PCA anastomosis by means of a venous graft was carried out on the right side in expectation of the rapid restoration of the blood flow in the affected brain stem. A venous graft was chosen because it would carry larger amount of blood immediately after completing the bypass surgery than small calibered arterial graft such as a superficial temporal artery.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[ECA-PCA anastomosis with the use of an interposition saphenous vein graft for vertebrobasilar progressing stroke]. 404 16

A 24-year-old woman with systemic lupus erythematosus (SLE) was admitted to our hospital because of diarrhea, vomiting, and epigastralgia. When she was diagnosed as SLE 5 years earlier, her renal function was normal and her urine protein excretion was 0.15 g/day. Renal biopsy revealed class V lupus nephritis, and she was treated with intravenous steroid (1 g methylprednisolone per day) for 3 days. The prednisolone dose was then reduced from 30 mg/day to 5 mg/day and maintained at that level until she was admitted to our hospital. Her abdominal X-ray, and CT scan showed massive ascites and excessive colonic gas. She was diagnosed as having ileus resulting from lupus peritonitis. The dose of prednisolone was increased up to 50 mg/day. After 1 week, the ascites disappeared and serum albumin and complement levels, lymphocyte count, and urine protein level returned to the normal range. When the prednisolone dose was reduced to 40 mg, however, UCG and an abdominal CT scan revealed thrombus in her right atrium, and inferior vena cava. Urokinase, argatroban and heparin were administered intravenously and warfarin was administered thereafter. Her thrombus gradually disappeared and she was discharged. These findings suggest that anticoagulation therapy is crucial for SLE patients with multiple complications receiving high-dose steroids.
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PMID:[Case of lupus peritonitis with thrombus in the right atrium]. 2041 37

We present a patient with hydrocephalus after tuberculous meningitis successfully treated with urokinase. She presented with multiple episodes of headache, fever, and vomiting. She underwent external ventricular drainage and was treated with urokinase in addition to dexamethasone, acetazolamide, and 4 antituberculous drugs. She was evaluated clinically, radiologically, and by laboratory work-up. On short-term clinical follow-up (3 months), she was asymptomatic after the treatment with urokinase. She was radiologically evaluated 3 weeks after the treatment. An MRI of the brain showed a decrease in ventricular size. Urokinase can be considered as a safe and promising adjunctive treatment for tuberculous meningitis hydrocephalus.
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PMID:Use of urokinase in the treatment of tuberculous meningitis hydrocephalus. 2104 79