Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042963 (vomiting)
 31,883 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This study determines the efficacy and incidence of side effects associated with intravaginal prostaglandin F2alpha (PGF2alpha). 20 healthy patients (16 to 30 years of age; 9-16 weeks gestational age) with no history of threatened abortion in the current pregnancy were studied. Baseline hematologic, metabolic, urinary, and hormonal studies were conducted. Transabdominal amniocentesis was performed in 7 patients. The uterus was observed for spontaneous contractility. Lactose tablets with 50 mg PGF2alpha (THAM salt) were administered vaginally. The intensity and frequency of uterine contractions in the 7 monitored patients determined the treatment regimen. Prostaglandin tablets were inserted at hourly intervals to maintain frequency of contractions at 5 per 10 minute time interval and/or intensity of contractions greater than an average of 40 mm Hg over a 10 minute-period. 13 patients whose uterine activity during the abortion process was assessed by clinical observation were given a similar time schedule. Blood studies were peformed 6 hours after the onset of therapy and immediately following abortion. Analgesia were used intramuscularly as antiemetic agents where necessary. Prepared questionnaires and personal interviews were completed at the 4-week clinic visit to determine patient acceptability of the method. 19 of 20 patients aborted, with 7 classified as complete and the remaining 12 requiring a uterine exploration and curettage for removal of retained placental fragments. Average induction-complete abortion interval was 17 hours and 50 minutes. There was no difference between multiparous and primiparous patients. In 1 patient who failed to abort with the prostaglandin tablet, administration of 900 mg PGF2alpha and hypertonic saline were used to facilitate abortion which occurred 24 hours later. Emesis occurred in 18 patients, diarrhea in 13, and fever in 11. Of 15 patients who agreed to an interview during the clinic visit, 14 stated they would choose the method again. Vaginal administration of PGs appears to exert effects by systemic, rather than by local mechanism. Although this method is effective, it has a high incidence of side effects and is associated with increased utilization of professional time.
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PMID:Abortifacient efficacy of intravaginal prostaglandin F2 . 468 31

Transient lactose intolerance secondary to infective diarrhoea is common in developing countries, & soya milk formula is commonly prescribed for its management. Lactose predigested milk feeding was done in 70 patients of test group while withdrawing lactose diet & 84.3% had control of motions with absent lactose in stool despite challenge feed, 3 days after withdrawal of lactose diet. 83.3% patients in control group fed soya milk had such improvement but the incidence of feed refusal was 30% in this group as compared to only 2.8% in lactaid group. Vomiting after feed was also found in 10% of babies fed soya milk as compared to none in lactaid group, thus proving superiority of lactaid in management of lactose intolerance diarrhoea.
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PMID:Dietary management of lactose intolerance--lactase treated milk versus soya milk. 851 40

(1) Dehydration is the most immediate complication of acute diarrhoea. Infants still die by dehydration, or suffer severe repercussions. (2) Thirst is an early sign of dehydration in an infant. Other signs are delayed capillary filling, absence of tears, mucosal dryness and a "sickly" appearance. Fever or vomiting in the first 24 hours facilitate dehydration. Weight loss is the main clinical index of the degree of dehydration. (3) Oral rehydration with glucose-electrolyte solution is as effective as intravenous rehydration. It must start immediately dehydration occurs. Infants with signs of severe dehydration must be hospitalised. (4) Oral rehydration of a vomiting infant is feasible, by giving a teaspoonful of solution every one or two minutes. (5) A dehydrated infant rarely refuses oral rehydration solutions. (6) Beverages such as cola drinks are inappropriate for rehydration, as they contain too little sodium and are excessively hyperosmolar, which may worsen the diarrhoea. Rice gruel is better. (7) Antidiarrhoeal drugs do not prevent dehydration. (8) Feeding must be resumed as soon as dehydration has been corrected, as it shortens the course of diarrhoea. Continuing maternal breast-feeding reduces the severity of diarrhoea. Lactose-free "milk" has no demonstrated benefit. (9) Those in charge of an infant with diarrhoea must know how to prevent severe dehydration, which can occur very rapidly. Fluid intake must always be increased in an infant with diarrhoea. Sachets of powder for oral rehydration should be kept at home. Their prescription and dispensing should be accompanied by written instructions.
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PMID:Acute diarrhoea in infants: oral rehydration is crucial. 1160 16