Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042963 (vomiting)
 31,883 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effectiveness and acceptability of Alfaprostol (an analog of PGF2 alpha) in inducing labor were assessed in 20 pregnant women at term. All subjects had no spontaneous uterine activity before treatment and the mean (M +/- SE) Bishop score was 2.45 +/- 0.21. The drug was administered by vaginal route at the dose of 10 mg every 3 hours. Regular uterine contractions appeared in all patients and delivery occurred in 85% of the patients after a mean time of 9h50min +/- 0h55min following the start of treatment. The mean dose of Alfaprostol utilized to achieve delivery was 29.4 +/- 2.0 mg. No major side effects were noted in the mothers and their fetuses at any time during treatment. Two patients exhibited vomiting. The Apgar score of all newborns at birth was 8 or more. These results suggest the usefulness of Alfaprostol to induce labor in pregnant women at term, as it has oxytocic activity without adverse effects on either the mother or the fetus.
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PMID:Vaginal treatment with a prostaglandin F2 alpha derivative (alfaprostol) for inducing labor in pregnancy at term. 344

The goal of this study was to compare three different medications for the induction of abortion in bitches between day 22 and 40 after mismating, to reduce the dosage and frequency of PGF2alpha applications and to investigate the effects of additional intravaginal applications of misoprostol, a PGE1 analog. For this purpose, 22 bitches of different breeds were assigned to three groups: group 1 (n = 6) received cabergoline (Galastop, 10 microg/kg daily, po) until abortion was complete (first application = day 0) and one administration of alfaprostol (Gabbrostim, 10 microg/kg at day 3, s. c.); group 2 (n = 9) was administered cabergoline (10 microg/kg daily, po) and alfaprostol (10 microg/kg at days 0 and 3, s. c.); and group 3 (n = 7) received the same combination as group 2 in addition to misoprostol (Cytotec, 400 microg for bitches with < or = 20 kg bw, 600 microg for bitches with > 20 kg bw, every other day, intravaginally). Abortion occurred in 83.3%, 77.7% and 100% of cases in group 1, 2 and 3, respectively (p > 0.05). Cervical dilatation time was shortest in group 3 (3.1 +/- 0.9 days vs. group 1:5.4 +/- 2.8 and group 2: 5.5 +/- 2.5; p < 0.05). Minor side effects like transient anorexia, weakness, mild vomiting and diarrhea or low grade hair loss were found in 30.3%, 54.3% and 54.0% of cases in group 1, 2 and 3, respectively. We conclude that a combination of oral cabergoline (10 microg/kg) and alfaprostol (10 microg/kg) is an effective method for inducing termination of pregnancy in bitches. However, a combination of oral cabergoline (10 microg/kg), alfaprostol (10 microg/kg) and administration of additional intravaginal misoprostol may be even more effective.
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PMID:Intravaginal application of misoprostol improves pregnancy termination with cabergoline and alfaprostol in dogs. 2049 31