Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0042963 (
vomiting
)
31,883
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A new neuroleptic drug,
Timiperone
, is able to exert an antiapomorphine effect at doses smaller than cataleptogenic doses. Nineteen patients with urologic malignancy undergoing chemotherapy with cisplatin in combination with other agents were studied for the antiemetic efficacy of
Timiperone
. Six of 8 patients over 46 years old treated with
Timiperone
6 mg/day p.o. from the day before undergoing DDP therapy to the last day of the therapy had no episode of
vomiting
and 2 patients had a few episodes of
emesis
(one and two episodes during 5 days of undergoing DDP, respectively). Five patients under 45 years old given
Timiperone
6 mg/day by the same method had few episodes of
vomiting
, but suffered from extrapyramidal symptoms. Finally 6 patients undergoing DDP with
Timiperone
in combination with trihexyphenidyl suffered no symptoms of catalepsy but sometimes had mild
vomiting
episodes (1-4 times a day). We would like to propose that in antiemetic therapy with
Timiperone
for cisplatin-induced nausea and vomiting, a dose of 4.5 mg/day be given from two days before undergoing chemotherapy because of the cumulative effect of
Timiperone
.
...
PMID:[Antiemetic therapy with timiperone in cisplatin-induced vomiting]. 375 27
