Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042963 (vomiting)
 31,883 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In a preliminary pilot study, the effect of disoprivan for sedation during regional anesthesia was investigated. In 15 patients (ASA I or II), lumbar epidural anesthesia with bupivacaine 0.75% was performed at L 3/4. For premedication morphine or pethidine combined with scopolamine was given. After injection of the local anesthetic, a 30-min period was allowed for establishing the physiological side effects of epidural blockade, to present any further changes in circulatory and/or cardiac function. Disoprivan (1 mg/kg body weight) was injected i.v. followed by continuous disoprivan infusion. Three groups of 5 patients each were given 1, 1.5, or 2 mg/kg per hour disoprivan. Changes in heart rate, blood pressure, and respiratory rate were studied. Recovery time and personal assessment of sleep were registered. Side-effects of clinical relevance from the cardiovascular and pulmonary systems were also registered. A dose-dependent upper airway obstruction that could easily be managed by an oral or nasal airway was seen in 9 of 15 patients. Eight patients had postoperative nausea or vomiting; 9 complained of pain during the bolus injection that they could not remember postoperatively. All patients described their sleep as pleasant. Recovery time from sleep was between 1 and 12 min. All changes from normal values increased in percentage with increasing disoprivan dosage. Disoprivan (1 or 1.5 mg/kg per hour) seems to be excellent for sedation during regional anesthesia and is perhaps even superior to other available drugs.
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PMID:[Disoprivan (Propofol) sedation during regional anesthesia. A pilot study]. 325 31

The injection anaesthetic propofol (Disoprivan) was used in 85 cats for performing gastroduodenoscopy. Anaesthesia and feasibility for executing endoscopy were evaluated. Two cats suffered from a transient (30 sec) respiratory arrest. In any other cases stable cardiovascular and acceptable respiratory conditions were observed. The endoscopy was easy to perform and no emesis was induced. Anaesthesia of the cat with propofol can be very well controlled. It is characterised by gentle induction and a recovery free from excitation.
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PMID:[Propofol--a short-term narcotic--tested in gastroduodenoscopy in the cat]. 847 Jan 10