Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0042963 (vomiting)
 31,883 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The paper describes two incidents of poisoning by the mushroom Chlorophyllum molybdites and reviews the literature covering this organism, a common agent of mushroom poisoning in many countries and the most common cause of mushroom poisoning in North America. Both poisoning incidents occurred in adults and were associated with severe gastrointestinal symptoms including profuse diarrhea, vomiting and intestinal pain. In each case, hospitalization was required. An unusual aspect of one case was the development of signs and symptoms suggestive of muscarine poisoning. The review includes a description of the mushroom, the geographic distribution of cases, the signs and symptoms of poisoning and its treatment, the toxic principles, particularly susceptible populations, and the variations in response associated with cooking C. molybdites and with individual idiosyncrasies. For identification of C. molybdites, the reader is alerted to the inappropriateness of some books, including many written in Europe, and is warned of the occasional finding of sterile mushrooms that lack its characteristic green basidiospores. Spores, as allergens, are discussed and simple rules are given for eaters of wild mushrooms.
 ...
PMID:Mushroom poisoning by Chlorophyllum molybdites in the Midwest United States. Cases and a review of the syndrome. 140 97

Mycetismus or mushroom poisoning is defined in Anisworth and Brisby's Dictionary of the Fungi as distress resulting from the consumption of a fungal organism. This is in contrast to mycotoxicosis where the fungus, usually a hyphomycete, acts on some foodstuff of humans or animals and alters it. The paper describes three incidents of poisoning by the mushroom Amanita virosa in the Hamadan region of Iran. Two poisoning incidents occurred in adults and one in a child. All patients were associated with severe gastrointestinal symptoms including profuse diarrhea, vomiting and intestinal pain. For identification of A. virosa, in addition to the case history and the symptoms, examination of kitchen waste was done and mushroom remains examined with 2% aqueous KOH, Melzer's reagent, using the identification keys of Bresinsky. Because this fungus is likely to be confused with edible mushrooms and mushroom hunting is a popular endeavor in some areas of the Hamadan region, it is important to educate people about the dangers involved.
 ...
PMID:Mycetismus in Hamadan, of west Iran. 944 38

The plant Cannabis has been known for centuries to be beneficial in a variety of gastrointestinal diseases, including emesis, diarrhea, inflammatory bowel disease and intestinal pain. delta9-tetrahydrocannabinol, the main psychotropic component of Cannabis, acts via at least two types of cannabinoid receptors, named CB1 and CB2 receptors. CB1 receptors are located primarily on central and peripheral neurons (including the enteric nervous system) where they modulate neurotransmitter release, whereas CB2 receptors are concerned with immune function, inflammation and pain. The discovery of endogenous ligands [i.e. anandamide and 2-arachidonoyl glycerol (2-AG)] for these receptors indicates the presence of a functional endogenous cannabinoid system in the gastrointestinal tract. Anatomical and functional evidence suggests the presence of CB1 receptors in the myenteric plexus, which are associated with cholinergic neurons in a variety of species, including in humans. Activation of prejunctional CB1 receptors reduces excitatory enteric transmission (mainly cholinergic transmission) in different regions of the gastrointestinal tract. Consistently, in vivo studies have shown that cannabinoids reduce gastrointestinal transit in rodents through activation of CB1, but not CB2, receptors. However, in pathophysiological states, both CB1 and CB2 receptors could reduce the increase of intestinal motility induced by inflammatory stimuli. Cannabinoids also reduce gastrointestinal motility in randomized clinical trials. Overall, modulation of the gut endogenous cannabinoid system may provide a useful therapeutic target for disorders of gastrointestinal motility.
 ...
PMID:Cannabinoids and gastrointestinal motility: animal and human studies. 1892 47

The plant Cannabis has been used in clinic for centuries, and has been known to be beneficial in a variety of gastrointestinal diseases, such as emesis, diarrhea, inflammatory bowel disease and intestinal pain. In this text, we'll review the components of the endogenous cannabinoid system as well as its role in the regulation of gastrointestinal activities, thus providing relative information for further study. Moreover, modulation of the endogenous cannabinoid system in gastrointestinal tract may provide a useful therapeutic target for gastrointestinal disorders.
...
PMID:Role of endogenous cannabinoid system in the gut. 2396 77